SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ryl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		5 / 12 ILE A 315
ALA A 377
ALA A 384
ARG A 306
GLU A 304
 None
 1.20A 2j0dA-3rylA:
undetectable		 2j0dA-3rylA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		4 / 5 ALA A 381
TRP A 284
LEU A 374
ALA A 380
 None
 1.17A 2jstA-3rylA:
undetectable
2jstB-3rylA:
undetectable		 2jstA-3rylA:
15.06
2jstB-3rylA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		4 / 7 ALA A 381
ILE A 378
ILE A 288
HIS A 285
 None
 1.09A 2zm7A-3rylA:
undetectable		 2zm7A-3rylA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA300_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		4 / 6 PHE A 435
TYR A 432
VAL A 405
PHE A 431
 None
 1.33A 3ltwA-3rylA:
undetectable		 3ltwA-3rylA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		4 / 7 TYR A 460
LEU A 409
LEU A 427
PHE A 448
 None
 1.13A 3nk2X-3rylA:
undetectable		 3nk2X-3rylA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		5 / 10 PHE A 424
PHE A 406
GLY A 430
PHE A 448
ASN A 452
 None
 1.33A 3r6wA-3rylA:
undetectable
3r6wB-3rylA:
undetectable		 3r6wA-3rylA:
22.35
3r6wB-3rylA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		4 / 8 PHE A 406
ALA A 273
PHE A 457
PHE A 448
 None
 0.88A 3t3sF-3rylA:
undetectable		 3t3sF-3rylA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		5 / 12 SER A 376
GLY A 370
PHE A 311
CYH A 312
GLU A 314
 None
 1.50A 4bupB-3rylA:
3.3		 4bupB-3rylA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		5 / 12 PHE A 457
LEU A 453
GLY A 414
MET A 412
LEU A 409
 None
 1.21A 4kykA-3rylA:
undetectable
4kykB-3rylA:
undetectable		 4kykA-3rylA:
19.92
4kykB-3rylA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		3 / 3 PHE A 254
THR A 402
LEU A 427
 None
 0.73A 4qztA-3rylA:
undetectable		 4qztA-3rylA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_E_DVAE7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		3 / 3 TYR A 307
SER A 386
TRP A 284
 None
 0.99A 5n8jB-3rylA:
undetectable		 5n8jB-3rylA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_O_DVAO7_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		3 / 3 TYR A 307
SER A 386
TRP A 284
 None
 1.04A 5n8jA-3rylA:
undetectable		 5n8jA-3rylA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N8J_P_DVAP5_0
(GLY-DTY-GLY-DLE-DAL-
DSG-DVA-DAS-DGL-DSN-
DSN-GLY
STREPTAVIDIN)		 3ryl PROTEIN VPA1370
(Vibrio
parahaemolyticus) 		3 / 3 TYR A 307
SER A 386
TRP A 284
 None
 1.06A 5n8jD-3rylA:
undetectable		 5n8jD-3rylA:
25.00