SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rys'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_A_STRA1_1
(PROGESTERONE
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.12A 1a28A-3rysA:
undetectable		 1a28A-3rysA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.07A 1a28B-3rysA:
undetectable		 1a28B-3rysA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		7 / 12 HIS A  19
HIS A  21
ASP A 103
PHE A  62
GLU A 202
HIS A 223
ASP A 280
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
None
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.26A 1a4lA-3rysA:
40.9		 1a4lA-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  19
HIS A  21
PHE A  62
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.53A 1a4lA-3rysA:
40.9		 1a4lA-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_A_DCFA353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
PHE A 285
PHE A  62
HIS A 223
ASP A 281
 ZN  A 344 (-3.5A)
None
None
ADE  A 345 ( 4.2A)
ADE  A 345 (-2.8A)
 1.09A 1a4lA-3rysA:
40.9		 1a4lA-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		7 / 12 HIS A  21
ASP A 103
PHE A  62
LEU A  63
GLU A 202
HIS A 223
ASP A 280
 ADE  A 345 ( 3.2A)
None
None
None
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.33A 1a4lB-3rysA:
40.7		 1a4lB-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
PHE A  62
HIS A 199
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
 1.16A 1a4lB-3rysA:
40.7		 1a4lB-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
PHE A  62
LEU A  59
HIS A 199
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
None
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 1.47A 1a4lB-3rysA:
40.7		 1a4lB-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  21
PHE A  62
LEU A  63
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
None
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.52A 1a4lB-3rysA:
40.7		 1a4lB-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_B_DCFB853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 PHE A  62
LEU A  63
HIS A 199
ASP A 280
ASP A 281
 None
None
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 1.31A 1a4lB-3rysA:
40.7		 1a4lB-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		7 / 12 HIS A  19
HIS A  21
ASP A 103
PHE A  62
GLU A 202
HIS A 223
ASP A 280
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
None
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.29A 1a4lC-3rysA:
40.8		 1a4lC-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  19
HIS A  21
PHE A  62
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.51A 1a4lC-3rysA:
40.8		 1a4lC-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
PHE A 285
PHE A  62
HIS A 223
ASP A 281
 ZN  A 344 (-3.5A)
None
None
ADE  A 345 ( 4.2A)
ADE  A 345 (-2.8A)
 1.03A 1a4lC-3rysA:
40.8		 1a4lC-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A 199
HIS A 223
PHE A 285
HIS A  19
HIS A  21
 ZN  A 344 ( 3.4A)
ADE  A 345 ( 4.2A)
None
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
 1.22A 1a4lC-3rysA:
40.8		 1a4lC-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
ASP A 103
PHE A  62
GLU A 202
HIS A 223
ASP A 280
 ADE  A 345 ( 3.2A)
None
None
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.31A 1a4lD-3rysA:
40.7		 1a4lD-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		7 / 12 HIS A  21
PHE A  62
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.48A 1a4lD-3rysA:
40.7		 1a4lD-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_D_DCFD1853_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
PHE A 285
PHE A  62
HIS A 199
ASP A 281
 ADE  A 345 ( 3.2A)
None
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
 1.41A 1a4lD-3rysA:
40.7		 1a4lD-3rysA:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C3S_A_SHHA952_1
(HDLP (HISTONE
DEACETYLASE-LIKE
PROTEIN))		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 11 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.31A 1c3sA-3rysA:
undetectable		 1c3sA-3rysA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_B_RALB600_2
(ESTROGEN RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.17A 1errB-3rysA:
undetectable		 1errB-3rysA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_C_HISC450_0
(HISTIDYL-TRNA
SYNTHETASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 185
TYR A 186
GLY A 169
GLY A 167
ALA A 140
 None
 1.17A 1httC-3rysA:
undetectable		 1httC-3rysA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NT2_A_SAMA301_1
(FIBRILLARIN-LIKE
PRE-RRNA PROCESSING
PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		3 / 3 THR A 245
GLU A 202
ASP A  58
 None
ADE  A 345 (-2.8A)
None
 0.85A 1nt2A-3rysA:
undetectable		 1nt2A-3rysA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 10 GLY A 167
LEU A 155
LEU A 185
TYR A 186
ALA A 140
 None
 1.21A 1pbcA-3rysA:
undetectable		 1pbcA-3rysA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQN_B_NDRB2001_0
(PROGESTERONE
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.12A 1sqnB-3rysA:
undetectable		 1sqnB-3rysA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.26A 1t69A-3rysA:
undetectable		 1t69A-3rysA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 ILE A 139
HIS A  21
HIS A  19
HIS A 199
 None
ADE  A 345 ( 3.2A)
ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
 0.88A 1y93A-3rysA:
undetectable		 1y93A-3rysA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 11 LEU A 143
HIS A  21
ASP A 281
GLY A  24
TYR A  66
 None
ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
ADE  A 345 (-4.0A)
 1.25A 1zz1A-3rysA:
undetectable		 1zz1A-3rysA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B17_A_DIFA701_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 10 ALA A 166
ILE A 165
GLY A 169
ASP A 222
PHE A 319
 None
 1.14A 2b17A-3rysA:
undetectable		 2b17A-3rysA:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 0.99A 2dcfA-3rysA:
undetectable		 2dcfA-3rysA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_2
(ESTROGEN RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.10A 2jfaA-3rysA:
undetectable		 2jfaA-3rysA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 138
MET A 161
LEU A 155
ARG A 188
LEU A 114
 None
 1.48A 2oaxA-3rysA:
undetectable		 2oaxA-3rysA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 138
MET A 161
LEU A 155
ARG A 188
LEU A 114
 None
 1.43A 2oaxC-3rysA:
undetectable		 2oaxC-3rysA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 LEU A 254
HIS A  19
HIS A  21
HIS A 199
 None
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
ZN  A 344 ( 3.4A)
 0.86A 2ow9A-3rysA:
undetectable		 2ow9A-3rysA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.20A 2p02A-3rysA:
undetectable		 2p02A-3rysA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
ASP A 103
PHE A  62
HIS A 223
SER A 250
ASP A 280
 ADE  A 345 ( 3.2A)
None
None
ADE  A 345 ( 4.2A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.21A 2pgfA-3rysA:
39.4		 2pgfA-3rysA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGF_A_ADNA501_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  21
PHE A  62
HIS A 199
GLU A 202
HIS A 223
SER A 250
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.38A 2pgfA-3rysA:
39.4		 2pgfA-3rysA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  19
HIS A  21
ASP A 103
PHE A  62
HIS A 223
ASP A 280
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
None
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 1.18A 2pgrA-3rysA:
39.4		 2pgrA-3rysA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  19
HIS A  21
PHE A  62
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.50A 2pgrA-3rysA:
39.4		 2pgrA-3rysA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_1
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A 199
HIS A 223
PHE A 285
HIS A  19
HIS A  21
 ZN  A 344 ( 3.4A)
ADE  A 345 ( 4.2A)
None
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
 1.13A 2pgrA-3rysA:
39.4		 2pgrA-3rysA:
27.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_2
(ESTROGEN RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.13A 2qxsA-3rysA:
undetectable		 2qxsA-3rysA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_B_RALB600_2
(ESTROGEN RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 LEU A 125
ASP A 131
LEU A  20
HIS A  97
 None
 1.13A 2qxsB-3rysA:
undetectable		 2qxsB-3rysA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  19
ILE A 139
HIS A 199
ASP A 222
 ZN  A 344 (-3.5A)
None
ZN  A 344 ( 3.4A)
None
 1.10A 2xadA-3rysA:
2.2		 2xadA-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_E_GCSE710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 199
ILE A 139
HIS A  21
ASP A 171
 ZN  A 344 ( 3.4A)
None
ADE  A 345 ( 3.2A)
ADE  A 345 (-4.0A)
 1.01A 2xadA-3rysA:
2.2		 2xadA-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_F_GCSF710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 199
ILE A 139
HIS A  21
ASP A 171
 ZN  A 344 ( 3.4A)
None
ADE  A 345 ( 3.2A)
ADE  A 345 (-4.0A)
 1.04A 2xadB-3rysA:
2.3		 2xadB-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  19
ILE A 139
HIS A 199
ASP A 222
 ZN  A 344 (-3.5A)
None
ZN  A 344 ( 3.4A)
None
 1.12A 2xadC-3rysA:
2.0		 2xadC-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_G_GCSG710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 199
ILE A 139
HIS A  21
ASP A 171
 ZN  A 344 ( 3.4A)
None
ADE  A 345 ( 3.2A)
ADE  A 345 (-4.0A)
 1.02A 2xadC-3rysA:
2.0		 2xadC-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  19
ILE A 139
HIS A 199
ASP A 222
 ZN  A 344 (-3.5A)
None
ZN  A 344 ( 3.4A)
None
 1.09A 2xadD-3rysA:
undetectable		 2xadD-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XAD_H_GCSH710_1
(N-ACYL GLM
PEUDO-TEICOPLANIN
DEACETYLASE
TEICOPLANIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A 199
ILE A 139
HIS A  21
ASP A 171
 ZN  A 344 ( 3.4A)
None
ADE  A 345 ( 3.2A)
ADE  A 345 (-4.0A)
 1.02A 2xadD-3rysA:
undetectable		 2xadD-3rysA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 0.99A 2zm7A-3rysA:
undetectable		 2zm7A-3rysA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM8_A_ACAA511_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 1.02A 2zm8A-3rysA:
undetectable		 2zm8A-3rysA:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 ALA A 141
TYR A 186
ILE A 139
ILE A 168
 None
 1.03A 2zmaA-3rysA:
undetectable		 2zmaA-3rysA:
24.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 PHE A  62
PHE A 285
LEU A 254
GLN A  60
TYR A  66
 None
None
None
None
ADE  A 345 (-4.0A)
 1.24A 3apwB-3rysA:
undetectable		 3apwB-3rysA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 HIS A  19
HIS A 199
ASP A 280
ASP A 281
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 1.07A 3c0zA-3rysA:
undetectable		 3c0zA-3rysA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_C_SHHC301_1
(HISTONE DEACETYLASE
7A)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 HIS A  19
HIS A 199
ASP A 280
ASP A 281
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 1.11A 3c0zC-3rysA:
undetectable		 3c0zC-3rysA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_A_NOGA1001_1
(PROGESTERONE
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.15A 3d90A-3rysA:
undetectable		 3d90A-3rysA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 273
ASN A 274
LEU A 237
LEU A 265
CYH A 276
 None
 1.12A 3d90B-3rysA:
undetectable		 3d90B-3rysA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEC_A_HAEA272_1
(COLLAGENASE 3)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 LEU A 254
HIS A  19
HIS A  21
HIS A 199
 None
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
ZN  A 344 ( 3.4A)
 0.91A 3kecA-3rysA:
undetectable		 3kecA-3rysA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KIV_A_ACAA100_1
(APOLIPOPROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 ASP A 281
ASP A 280
PHE A  56
ARG A 253
 ADE  A 345 (-2.8A)
ZN  A 344 ( 2.5A)
None
None
 1.45A 3kivA-3rysA:
undetectable		 3kivA-3rysA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LJG_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 ILE A 139
HIS A  21
HIS A  19
HIS A 199
 None
ADE  A 345 ( 3.2A)
ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
 0.97A 3ljgA-3rysA:
undetectable		 3ljgA-3rysA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 10 PRO A 104
ILE A 165
VAL A 121
ILE A 139
ILE A 100
 None
 1.15A 3p4wD-3rysA:
undetectable		 3p4wD-3rysA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		3 / 3 HIS A 199
HIS A  19
HIS A  21
 ZN  A 344 ( 3.4A)
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
 0.61A 3qpkA-3rysA:
undetectable		 3qpkA-3rysA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VKX_A_T3A301_1
(PROLIFERATING CELL
NUCLEAR ANTIGEN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 LEU A  65
PRO A  28
GLN A  27
TYR A 284
 None
 1.32A 3vkxA-3rysA:
undetectable		 3vkxA-3rysA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 LEU A  59
LEU A  63
HIS A 199
GLU A 202
GLU A 174
HIS A 223
SER A 250
ASP A 280
 ADE  A 345 (-4.5A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ADE  A 345 ( 4.2A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
 0.78A 4aqlA-3rysA:
22.4		 4aqlA-3rysA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 10 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.20A 4bz6A-3rysA:
undetectable		 4bz6A-3rysA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_B_SHHB700_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.22A 4bz6A-3rysA:
undetectable
4bz6B-3rysA:
undetectable		 4bz6A-3rysA:
21.41
4bz6B-3rysA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_C_SHHC700_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.22A 4bz6C-3rysA:
undetectable		 4bz6C-3rysA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_D_SHHD700_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 10 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.22A 4bz6D-3rysA:
undetectable		 4bz6D-3rysA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EF3_A_CUA1002_0
(BLUE COPPER OXIDASE
CUEO)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 4 HIS A  19
HIS A  21
HIS A 223
HIS A 199
 ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 3.4A)
 0.93A 4ef3A-3rysA:
undetectable		 4ef3A-3rysA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 ASP A 280
ASP A 222
ASP A 103
GLU A 174
 ZN  A 344 ( 2.5A)
None
None
None
 1.21A 4fevB-3rysA:
undetectable		 4fevB-3rysA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.20A 4kttA-3rysA:
undetectable		 4kttA-3rysA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_A_SHHA407_1
(HISTONE DEACETYLASE
2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.18A 4lxzA-3rysA:
undetectable		 4lxzA-3rysA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_B_SHHB408_1
(HISTONE DEACETYLASE
2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 11 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.18A 4lxzB-3rysA:
undetectable		 4lxzB-3rysA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LXZ_C_SHHC406_1
(HISTONE DEACETYLASE
2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.18A 4lxzC-3rysA:
undetectable		 4lxzC-3rysA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 125
ARG A  84
ILE A  22
LEU A  30
LEU A  87
 None
 1.26A 4m11A-3rysA:
undetectable		 4m11A-3rysA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.25A 4ndnC-3rysA:
undetectable		 4ndnC-3rysA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJG_B_SAMB302_0
(7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 GLU A  17
ASN A 313
SER A 314
VAL A  15
ASP A 290
 None
 1.18A 4njgB-3rysA:
2.0		 4njgB-3rysA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODJ_A_SAMA500_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.16A 4odjA-3rysA:
undetectable		 4odjA-3rysA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.27A 4qa0A-3rysA:
undetectable		 4qa0A-3rysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 11 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.26A 4qa0B-3rysA:
undetectable		 4qa0B-3rysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.27A 4qa2A-3rysA:
undetectable		 4qa2A-3rysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.29A 4qa2B-3rysA:
undetectable		 4qa2B-3rysA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
HIS A 223
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 ( 4.2A)
None
ZN  A 344 ( 2.5A)
 0.39A 4r88A-3rysA:
23.8		 4r88A-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.41A 4r88A-3rysA:
23.8		 4r88A-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
GLU A 202
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ZN  A 344 ( 2.5A)
 0.36A 4r88B-3rysA:
23.9		 4r88B-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_B_1LDB501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.43A 4r88B-3rysA:
23.9		 4r88B-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
GLU A 202
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ZN  A 344 ( 2.5A)
 0.38A 4r88C-3rysA:
23.8		 4r88C-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_C_1LDC501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.43A 4r88C-3rysA:
23.8		 4r88C-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
GLU A 202
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ZN  A 344 ( 2.5A)
 0.37A 4r88D-3rysA:
23.7		 4r88D-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_D_1LDD501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.42A 4r88D-3rysA:
23.7		 4r88D-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
GLU A 202
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ZN  A 344 ( 2.5A)
 0.39A 4r88E-3rysA:
23.9		 4r88E-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_E_1LDE501_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.44A 4r88E-3rysA:
23.9		 4r88E-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
HIS A 199
GLU A 202
LEU A 254
ASP A 280
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
None
ZN  A 344 ( 2.5A)
 0.34A 4r88F-3rysA:
24.0		 4r88F-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_F_1LDF502_0
(CYTOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
LEU A 254
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
None
ADE  A 345 (-2.8A)
 1.42A 4r88F-3rysA:
24.0		 4r88F-3rysA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 6 LEU A 216
VAL A 215
ARG A 184
PHE A 182
 None
 1.09A 4uswA-3rysA:
undetectable		 4uswA-3rysA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.21A 5a1iA-3rysA:
undetectable		 5a1iA-3rysA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_A_PAUA602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 GLY A 287
SER A 279
TYR A  86
ALA A 283
 None
 1.01A 5e26A-3rysA:
undetectable
5e26B-3rysA:
1.6		 5e26A-3rysA:
22.08
5e26B-3rysA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E3I_A_HISA502_0
(HISTIDINE--TRNA
LIGASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 185
TYR A 186
GLY A 169
GLY A 167
ALA A 140
 None
 1.11A 5e3iA-3rysA:
undetectable		 5e3iA-3rysA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_A_SHHA2004_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.25A 5eeiA-3rysA:
undetectable		 5eeiA-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEI_B_SHHB801_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.24A 5eeiB-3rysA:
undetectable		 5eeiB-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_A_5OGA804_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.29A 5eenA-3rysA:
undetectable		 5eenA-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.28A 5eenB-3rysA:
undetectable		 5eenB-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
LEU A  63
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
None
ADE  A 345 (-4.0A)
 1.25A 5eenB-3rysA:
undetectable		 5eenB-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_A_LBHA2004_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.32A 5ef8A-3rysA:
undetectable		 5ef8A-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
ASP A 281
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
ADE  A 345 (-4.0A)
 1.34A 5ef8B-3rysA:
undetectable		 5ef8B-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF8_B_LBHB2004_1
(HDAC6 PROTEIN)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  19
HIS A 199
ASP A 280
LEU A  63
TYR A  66
 ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
None
ADE  A 345 (-4.0A)
 1.34A 5ef8B-3rysA:
undetectable		 5ef8B-3rysA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		3 / 3 HIS A 199
HIS A  19
HIS A  21
 ZN  A 344 ( 3.4A)
ZN  A 344 (-3.5A)
ADE  A 345 ( 3.2A)
 0.59A 5migA-3rysA:
undetectable		 5migA-3rysA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5K_A_HAEA306_1
(MACROPHAGE
METALLOELASTASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 5 ILE A 139
HIS A  21
HIS A  19
HIS A 199
 None
ADE  A 345 ( 3.2A)
ZN  A 344 (-3.5A)
ZN  A 344 ( 3.4A)
 0.89A 5n5kA-3rysA:
undetectable		 5n5kA-3rysA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 LEU A 244
ILE A 221
ILE A 197
PHE A 319
LEU A 213
 None
 1.45A 5uanB-3rysA:
undetectable		 5uanB-3rysA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 8 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.21A 6fcdA-3rysA:
undetectable		 6fcdA-3rysA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G6R_A_SAMA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		4 / 7 HIS A  21
ASP A 281
SER A  61
PHE A  62
 ADE  A 345 ( 3.2A)
ADE  A 345 (-2.8A)
None
None
 1.21A 6g6rA-3rysA:
undetectable		 6g6rA-3rysA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.86A 6n91A-3rysA:
42.7		 6n91A-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		6 / 12 HIS A  21
LEU A  59
LEU A  63
HIS A 199
GLU A 202
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 (-2.8A)
 1.19A 6n91A-3rysA:
42.7		 6n91A-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  21
LEU A  59
LEU A  63
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.56A 6n91A-3rysA:
42.7		 6n91A-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_A_DCFA401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A 199
LEU A  63
LEU A  59
SER A 250
HIS A  21
 ZN  A 344 ( 3.4A)
None
ADE  A 345 (-4.5A)
ADE  A 345 ( 4.2A)
ADE  A 345 ( 3.2A)
 1.09A 6n91A-3rysA:
42.7		 6n91A-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
HIS A 199
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
ZN  A 344 ( 3.4A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.89A 6n91B-3rysA:
42.8		 6n91B-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A  21
LEU A  59
LEU A  63
GLU A 202
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
None
ADE  A 345 (-2.8A)
ADE  A 345 (-2.8A)
 1.20A 6n91B-3rysA:
42.8		 6n91B-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		8 / 12 HIS A  21
LEU A  59
LEU A  63
HIS A 199
GLU A 202
HIS A 223
ASP A 280
ASP A 281
 ADE  A 345 ( 3.2A)
ADE  A 345 (-4.5A)
None
ZN  A 344 ( 3.4A)
ADE  A 345 (-2.8A)
ADE  A 345 ( 4.2A)
ZN  A 344 ( 2.5A)
ADE  A 345 (-2.8A)
 0.63A 6n91B-3rysA:
42.8		 6n91B-3rysA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6N91_B_DCFB401_0
(ADENOSINE DEAMINASE)		 3rys ADENOSINE DEAMINASE
1
(Paenarthrobacter
aurescens) 		5 / 12 HIS A 199
LEU A  63
LEU A  59
SER A 250
HIS A  21
 ZN  A 344 ( 3.4A)
None
ADE  A 345 (-4.5A)
ADE  A 345 ( 4.2A)
ADE  A 345 ( 3.2A)
 1.06A 6n91B-3rysA:
42.8		 6n91B-3rysA:
13.12