SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3rza'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 LEU A 339
VAL A 337
TYR A 164
THR A 175
 None
 1.33A 1nw3A-3rzaA:
undetectable		 1nw3A-3rzaA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TT6_B_DESB128_1
(TRANSTHYRETIN)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 LEU A 311
ALA A 362
LEU A 360
SER A 357
 None
 1.10A 1tt6B-3rzaA:
undetectable		 1tt6B-3rzaA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ASP A 167
ILE A 346
ILE A 148
SER A 145
ALA A 150
 ZN  A 401 (-2.2A)
None
None
None
None
 1.24A 2ejtA-3rzaA:
undetectable		 2ejtA-3rzaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_2
(MINERALOCORTICOID
RECEPTOR)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 5 LEU A  76
LEU A 115
CYH A  60
THR A  61
 None
 1.28A 2oaxD-3rzaA:
undetectable		 2oaxD-3rzaA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 11 GLN A 136
LEU A 157
ALA A  48
LEU A  31
GLN A  28
 None
None
CA  A 405 (-4.9A)
None
None
 1.45A 3jwqA-3rzaA:
undetectable
3jwqD-3rzaA:
undetectable		 3jwqA-3rzaA:
22.52
3jwqD-3rzaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 ASP A  81
GLY A  54
PRO A  29
ILE A  30
ILE A  27
 None
CA  A 405 ( 4.5A)
None
None
None
 1.00A 3s56B-3rzaA:
undetectable		 3s56B-3rzaA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		6 / 12 GLY A 114
ALA A 117
PHE A  11
GLU A 351
LEU A 339
VAL A 341
 None
 1.46A 4azsA-3rzaA:
undetectable		 4azsA-3rzaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		6 / 12 GLY A 114
ALA A 117
PHE A  11
GLU A 351
LEU A 339
VAL A 341
 None
 1.46A 4aztA-3rzaA:
undetectable		 4aztA-3rzaA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZW_A_SAMA1451_0
(WBDD)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		6 / 12 GLY A 114
ALA A 117
PHE A  11
GLU A 351
LEU A 339
VAL A 341
 None
 1.46A 4azwA-3rzaA:
undetectable		 4azwA-3rzaA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		3 / 3 PHE A 332
VAL A 300
ILE A 294
 None
 0.60A 4emaA-3rzaA:
undetectable		 4emaA-3rzaA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_A_CLQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 GLY A 322
GLY A 323
TYR A 289
ILE A 338
PHE A 292
 CIT  A 407 (-3.5A)
CIT  A 407 (-3.8A)
CIT  A 407 (-4.6A)
None
None
 1.24A 4fglA-3rzaA:
undetectable
4fglB-3rzaA:
3.0		 4fglA-3rzaA:
22.00
4fglB-3rzaA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		7 / 11 HIS A  79
ASP A 110
GLU A 143
GLU A 144
GLY A 321
GLY A 322
HIS A 347
 ZN  A 401 (-3.3A)
ZN  A 401 ( 2.5A)
ZN  A 401 ( 3.8A)
CA  A 402 (-2.2A)
IPA  A 408 (-3.6A)
CIT  A 407 (-3.5A)
CA  A 402 (-3.4A)
 0.56A 4pqaA-3rzaA:
35.2		 4pqaA-3rzaA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		7 / 11 HIS A  79
ASP A 110
GLU A 143
GLU A 144
GLY A 322
ILE A 346
HIS A 347
 ZN  A 401 (-3.3A)
ZN  A 401 ( 2.5A)
ZN  A 401 ( 3.8A)
CA  A 402 (-2.2A)
CIT  A 407 (-3.5A)
None
CA  A 402 (-3.4A)
 0.56A 4pqaA-3rzaA:
35.2		 4pqaA-3rzaA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 9 ILE A 371
LEU A 360
VAL A 121
LEU A 366
ILE A   2
 None
 1.31A 4r38C-3rzaA:
undetectable		 4r38C-3rzaA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 LEU A 361
GLY A 163
LEU A  74
VAL A 372
VAL A 121
 None
 1.03A 4wnwA-3rzaA:
undetectable		 4wnwA-3rzaA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 ASN A 359
LYS A 356
TYR A  98
TYR A 100
 None
PG4  A 416 (-2.8A)
None
PEG  A 409 (-3.7A)
 0.72A 4yv5A-3rzaA:
undetectable		 4yv5A-3rzaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 7 ASN A 359
LYS A 356
TYR A  98
TYR A 100
 None
PG4  A 416 (-2.8A)
None
PEG  A 409 (-3.7A)
 0.79A 4yv5B-3rzaA:
undetectable		 4yv5B-3rzaA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 VAL A 138
LEU A  53
GLY A 149
ALA A 150
 None
 0.60A 5f1aA-3rzaA:
undetectable		 5f1aA-3rzaA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3N_C_ADNC505_1
(-)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		5 / 12 ASP A  81
GLU A 144
ASP A 110
LEU A 115
GLY A 114
 None
CA  A 402 (-2.2A)
ZN  A 401 ( 2.5A)
None
None
 1.43A 6f3nC-3rzaA:
undetectable		 6f3nC-3rzaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.12A 6mn4A-3rzaA:
undetectable		 6mn4A-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_A_AM2A301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 HIS A  50
GLU A  24
ASP A  81
GLU A 144
 None
None
None
CA  A 402 (-2.2A)
 1.06A 6mn4A-3rzaA:
undetectable		 6mn4A-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.25A 6mn4B-3rzaA:
undetectable		 6mn4B-3rzaA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3rza TRIPEPTIDASE
(Staphylococcus
aureus) 		4 / 8 HIS A  50
GLU A  24
ASP A  81
GLU A 143
 None
None
None
ZN  A 401 ( 3.8A)
 1.17A 6mn4D-3rzaA:
undetectable		 6mn4D-3rzaA:
24.10