SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s1s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBY_B_9CRB1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A  28
CYH A  29
ALA A  31
ALA A  32
GLN A  35
 None
 0.84A 1fbyB-3s1sA:
undetectable		 1fbyB-3s1sA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_2
(HIV-1 PROTEASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ARG A 648
THR A 663
VAL A 665
 None
 0.94A 1hxbA-3s1sA:
undetectable		 1hxbA-3s1sA:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_A_KANA558_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 SER A 547
GLU A 524
GLU A 521
GLU A 491
 None
 0.71A 1knyA-3s1sA:
undetectable
1knyB-3s1sA:
undetectable		 1knyA-3s1sA:
14.87
1knyB-3s1sA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QAO_A_SAMA245_0
(ERMC'
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 GLY A 331
ILE A 356
ASP A 388
ASN A 406
PRO A 408
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
 0.68A 1qaoA-3s1sA:
10.4		 1qaoA-3s1sA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A 684
ALA A 674
LEU A 689
ILE A 624
LEU A 634
 None
 1.11A 1rx3A-3s1sA:
2.1		 1rx3A-3s1sA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A 684
ALA A 674
LEU A 689
ILE A 624
LEU A 634
 None
 1.01A 1rx7A-3s1sA:
undetectable		 1rx7A-3s1sA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A 684
ALA A 674
LEU A 689
ILE A 624
LEU A 634
 None
 1.11A 1rx8A-3s1sA:
undetectable		 1rx8A-3s1sA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 LEU A 279
LEU A 282
ILE A 283
ILE A 286
LEU A 266
 None
None
None
None
IOD  A 962 ( 4.6A)
 1.00A 1xdkF-3s1sA:
undetectable		 1xdkF-3s1sA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_A_9CRA201_1
(RXR-LIKE PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A  28
CYH A  29
ALA A  31
ALA A  32
GLN A  35
 None
 0.92A 1xiuA-3s1sA:
undetectable		 1xiuA-3s1sA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA501_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 9 GLY A 614
SER A 619
LEU A 622
TYR A 692
LEU A 716
 None
EDO  A 919 (-4.0A)
None
None
None
 1.28A 1y7iA-3s1sA:
2.5		 1y7iA-3s1sA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 LEU A 266
LEU A 269
LEU A 282
LEU A 198
 IOD  A 962 ( 4.6A)
IOD  A 962 ( 4.3A)
None
None
 0.74A 2ab2A-3s1sA:
undetectable		 2ab2A-3s1sA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 ALA A 329
ILE A 356
ASP A 388
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-4.0A)
None
 0.93A 2admA-3s1sA:
10.5		 2admA-3s1sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 ALA A 329
ILE A 356
ASP A 388
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-4.0A)
None
 0.92A 2admB-3s1sA:
19.8		 2admB-3s1sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 9 LEU A 794
LEU A 755
ILE A 731
PHE A 781
LEU A 802
 None
IOD  A 956 ( 4.2A)
None
None
None
 1.23A 2f78A-3s1sA:
undetectable		 2f78A-3s1sA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 ALA A 329
GLY A 331
ASN A 334
LEU A 335
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
EDO  A 906 ( 3.7A)
IOD  A 938 (-4.1A)
SAH  A 900 (-4.0A)
None
 0.82A 2f8lA-3s1sA:
0.0		 2f8lA-3s1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 HIS A 293
ALA A 329
GLY A 331
ASN A 334
LEU A 335
 None
SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
EDO  A 906 ( 3.7A)
IOD  A 938 (-4.1A)
 0.95A 2f8lA-3s1sA:
0.0		 2f8lA-3s1sA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HKK_A_ALEA300_1
(CARBONIC ANHYDRASE 2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 ASN A   7
ASN A  39
ILE A 163
GLN A 160
 None
 1.25A 2hkkA-3s1sA:
undetectable		 2hkkA-3s1sA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 330
GLY A 369
LEU A 370
LEU A 336
SER A 340
 None
 1.32A 2nv4B-3s1sA:
undetectable		 2nv4B-3s1sA:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 331
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.65A 2okcA-3s1sA:
20.9		 2okcA-3s1sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 331
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.59A 2okcB-3s1sA:
20.8		 2okcB-3s1sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 333
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.95A 2okcB-3s1sA:
20.8		 2okcB-3s1sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 GLY A 202
GLY A 236
ILE A 283
ALA A 201
LEU A 180
 None
 1.10A 2plwA-3s1sA:
10.0		 2plwA-3s1sA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ARG A 648
THR A 663
VAL A 665
 None
 1.00A 2qakA-3s1sA:
undetectable		 2qakA-3s1sA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A 283
ALA A 197
TYR A 205
VAL A 209
LEU A 279
 None
 1.26A 2rctA-3s1sA:
undetectable		 2rctA-3s1sA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 LEU A 621
LEU A 668
SER A 682
LEU A 685
LEU A 634
 None
 1.06A 2xn5A-3s1sA:
undetectable		 2xn5A-3s1sA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ASP A  60
HIS A  51
HIS A  26
 MN  A 930 (-2.5A)
None
None
 0.70A 2xxgC-3s1sA:
undetectable		 2xxgC-3s1sA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 ALA A 329
GLY A 331
GLY A 333
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 1.16A 2y7hB-3s1sA:
18.0		 2y7hB-3s1sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_0
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 ALA A 329
GLY A 331
GLY A 333
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 1.16A 2y7hC-3s1sA:
18.7		 2y7hC-3s1sA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 GLY A 331
LEU A 335
VAL A 389
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.96A 2zulA-3s1sA:
11.1		 2zulA-3s1sA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_A_ADNA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 10 PHE A 447
ILE A 356
ASP A 388
VAL A 389
PHE A 422
 None
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 ( 4.9A)
 1.39A 3ay0A-3s1sA:
6.0		 3ay0A-3s1sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 10 GLY A 331
ASP A 355
ILE A 356
ASP A 388
VAL A 389
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.8A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
 0.50A 3ay0B-3s1sA:
5.9		 3ay0B-3s1sA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 LEU A 448
ALA A 463
VAL A 511
LEU A 560
LEU A 540
 None
 1.35A 3b0wB-3s1sA:
undetectable		 3b0wB-3s1sA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 ASP A 388
LEU A 392
ASP A 355
LEU A 364
 SAH  A 900 (-4.1A)
None
SAH  A 900 (-2.8A)
None
 1.18A 3bj8C-3s1sA:
undetectable
3bj8D-3s1sA:
undetectable		 3bj8C-3s1sA:
11.39
3bj8D-3s1sA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_G_SAMG302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 GLY A 331
SER A 332
LEU A 335
ILE A 356
ASN A 406
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
 0.78A 3cjtG-3s1sA:
11.7		 3cjtG-3s1sA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 GLY A 331
SER A 332
LEU A 335
ILE A 356
ASN A 406
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
 0.73A 3cjtO-3s1sA:
11.6		 3cjtO-3s1sA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 GLY A 331
ASP A 388
VAL A 389
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.84A 3dmfA-3s1sA:
11.6		 3dmfA-3s1sA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 12 GLY A 331
LEU A 335
VAL A 389
ASN A 406
PRO A 408
PHE A 447
 SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 0.93A 3dmhA-3s1sA:
11.6		 3dmhA-3s1sA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 331
LEU A 335
ASP A 388
GLY A 295
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
IOD  A 938 (-4.1A)
SAH  A 900 (-4.1A)
SAH  A 900 ( 3.7A)
 1.03A 3g2oB-3s1sA:
11.8		 3g2oB-3s1sA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 PRO A 250
LYS A 226
ALA A 222
PRO A 229
 None
None
EDO  A 910 (-3.7A)
EDO  A 907 (-4.4A)
 1.30A 3gv1A-3s1sA:
undetectable
3gv1C-3s1sA:
undetectable		 3gv1A-3s1sA:
9.91
3gv1C-3s1sA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 LYS A 226
ALA A 222
PRO A 229
PRO A 250
 None
EDO  A 910 (-3.7A)
EDO  A 907 (-4.4A)
None
 1.24A 3gv1A-3s1sA:
undetectable
3gv1B-3s1sA:
undetectable		 3gv1A-3s1sA:
9.91
3gv1B-3s1sA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 GLY A 331
ASP A 355
ASP A 388
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.8A)
SAH  A 900 (-4.1A)
 0.20A 3ou7C-3s1sA:
8.5		 3ou7C-3s1sA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 LEU A 361
ASP A 327
ILE A 351
VAL A 243
ILE A 384
 None
None
None
EDO  A 913 (-3.8A)
EDO  A 913 (-4.2A)
 1.36A 3oxxB-3s1sA:
undetectable		 3oxxB-3s1sA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZV_B_ECNB411_1
(FLAVOHEMOGLOBIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		6 / 9 ILE A 163
ILE A 162
PHE A 159
LEU A  73
LEU A  33
ALA A  36
 None
 1.07A 3ozvB-3s1sA:
3.6		 3ozvB-3s1sA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 GLY A 171
ALA A 170
ASP A 169
ILE A 162
 None
 0.66A 3t3cA-3s1sA:
undetectable		 3t3cA-3s1sA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 GLY A 331
SER A 332
VAL A 389
ASN A 406
PRO A 408
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
 0.61A 3v8vA-3s1sA:
11.8		 3v8vA-3s1sA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		7 / 11 GLY A 331
ASP A 355
ASP A 388
VAL A 389
ASN A 406
PRO A 408
TYR A 409
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.5A)
SAH  A 900 (-4.0A)
None
 1.08A 3v8vB-3s1sA:
9.5		 3v8vB-3s1sA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_C_SAMC401_1
(MNMC2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 GLY A 295
ASP A 285
ASN A 334
GLU A 281
 SAH  A 900 ( 3.7A)
None
EDO  A 906 ( 3.7A)
None
 0.95A 3vywC-3s1sA:
9.0		 3vywC-3s1sA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ARG A 481
ARG A 571
TRP A 576
 None
 1.49A 4cpzG-3s1sA:
undetectable		 4cpzG-3s1sA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 8 ASN A 259
ASN A 253
THR A 252
TRP A 258
 IOD  A 935 ( 4.7A)
None
None
None
 1.15A 4d1yA-3s1sA:
2.6
4d1yB-3s1sA:
2.8		 4d1yA-3s1sA:
12.76
4d1yB-3s1sA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_B_REAB1501_1
(RETINOIC ACID
RECEPTOR BETA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 LEU A 279
LEU A 282
ILE A 283
GLY A 202
LEU A 263
 None
None
None
None
EDO  A 910 (-3.8A)
 1.05A 4dm8B-3s1sA:
undetectable		 4dm8B-3s1sA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ASN A 255
ASP A 256
ILE A 257
VAL A 200
ARG A 187
 None
 1.16A 4dx5B-3s1sA:
undetectable		 4dx5B-3s1sA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 ASN A 582
GLU A 782
GLU A 868
ARG A 869
 None
 1.03A 4mi4B-3s1sA:
undetectable
4mi4C-3s1sA:
undetectable		 4mi4B-3s1sA:
11.78
4mi4C-3s1sA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 8 ASN A 582
GLU A 782
GLU A 868
ARG A 869
 None
 1.03A 4mj8B-3s1sA:
undetectable
4mj8C-3s1sA:
undetectable		 4mj8B-3s1sA:
10.99
4mj8C-3s1sA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 8 SER A 762
HIS A 727
ILE A 819
GLU A 745
 None
 1.23A 4ms4A-3s1sA:
4.3		 4ms4A-3s1sA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ARG A 498
GLU A 503
ARG A  88
 IOD  A 948 ( 4.1A)
None
IOD  A 948 ( 3.7A)
 0.85A 4mwvA-3s1sA:
undetectable		 4mwvA-3s1sA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 331
SER A 332
ILE A 356
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
SAH  A 900 (-3.8A)
None
 1.20A 4obwA-3s1sA:
11.5		 4obwA-3s1sA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 LEU A 768
LEU A 601
ILE A 799
LEU A 802
PHE A 781
 None
 1.09A 4odrA-3s1sA:
undetectable
4odrB-3s1sA:
undetectable		 4odrA-3s1sA:
7.86
4odrB-3s1sA:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 5 TYR A 224
LEU A 232
GLU A 235
TYR A 203
 None
 1.49A 4olaA-3s1sA:
3.6		 4olaA-3s1sA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PCU_A_SAMA603_0
(CYSTATHIONINE
BETA-SYNTHASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 7 ASP A 300
PRO A 407
THR A 509
ILE A 506
ASP A 508
 None
 1.32A 4pcuA-3s1sA:
4.6		 4pcuA-3s1sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 10 LEU A 621
LEU A 668
SER A 682
LEU A 685
LEU A 634
 None
 1.16A 4yiaA-3s1sA:
undetectable		 4yiaA-3s1sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 SER A 340
ALA A 341
PRO A 348
LEU A 368
 None
EDO  A 906 ( 4.7A)
None
None
 1.12A 5dzkD-3s1sA:
undetectable
5dzkR-3s1sA:
undetectable		 5dzkD-3s1sA:
13.67
5dzkR-3s1sA:
2.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ILE A 464
GLY A 304
ILE A 301
ILE A 506
PRO A 298
 None
None
None
None
EDO  A 912 ( 4.8A)
 1.04A 5e72A-3s1sA:
13.0		 5e72A-3s1sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 4 ASP A 327
GLY A 331
ASP A 355
ASP A 388
 None
SAH  A 900 (-3.2A)
SAH  A 900 (-2.8A)
SAH  A 900 (-4.1A)
 0.53A 5e72A-3s1sA:
13.0		 5e72A-3s1sA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 GLY A 331
SER A 332
ASP A 388
ASP A 327
 SAH  A 900 (-3.2A)
SAH  A 900 (-2.6A)
SAH  A 900 (-4.1A)
None
 0.74A 5ergB-3s1sA:
9.6		 5ergB-3s1sA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 VAL A  48
ILE A 163
ASN A 113
PHE A  61
 None
 0.87A 5hieC-3s1sA:
undetectable		 5hieC-3s1sA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 GLY A 331
ILE A 356
ASP A 388
VAL A 389
PRO A 408
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.0A)
 0.68A 5hjiA-3s1sA:
10.6		 5hjiA-3s1sA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 11 PHE A 447
ILE A 356
ASP A 388
VAL A 389
PRO A 408
 None
SAH  A 900 (-3.8A)
SAH  A 900 (-4.1A)
SAH  A 900 (-3.8A)
SAH  A 900 (-4.0A)
 1.33A 5hjiA-3s1sA:
10.6		 5hjiA-3s1sA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA615_1
(PHIAB6 TAILSPIKE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 TYR A 109
TYR A 173
GLN A 132
 None
IOD  A 941 (-4.9A)
None
 1.09A 5jsdA-3s1sA:
undetectable
5jsdB-3s1sA:
undetectable		 5jsdA-3s1sA:
20.95
5jsdB-3s1sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 VAL A  75
GLU A 533
GLU A  21
 None
MN  A 930 ( 4.3A)
MN  A 930 (-2.6A)
 0.80A 5jsdB-3s1sA:
undetectable
5jsdC-3s1sA:
undetectable		 5jsdB-3s1sA:
20.95
5jsdC-3s1sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB603_1
(PHIAB6 TAILSPIKE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 VAL A  84
GLU A 533
GLU A  21
 None
MN  A 930 ( 4.3A)
MN  A 930 (-2.6A)
 0.87A 5jsdB-3s1sA:
undetectable
5jsdC-3s1sA:
undetectable		 5jsdB-3s1sA:
20.95
5jsdC-3s1sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB606_1
(PHIAB6 TAILSPIKE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 TYR A 109
TYR A 173
GLN A 132
 None
IOD  A 941 (-4.9A)
None
 1.08A 5jsdB-3s1sA:
undetectable
5jsdC-3s1sA:
undetectable		 5jsdB-3s1sA:
20.95
5jsdC-3s1sA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 ASN A 113
TYR A  25
CYH A  29
 None
 0.98A 5lsuB-3s1sA:
undetectable		 5lsuB-3s1sA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 GLN A 778
ARG A 792
CYH A 598
PHE A 846
 None
 1.45A 5mwyA-3s1sA:
undetectable		 5mwyA-3s1sA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 SER A 519
ASN A 487
LEU A 484
GLU A 569
LEU A 490
 None
 1.48A 5nvpA-3s1sA:
0.0		 5nvpA-3s1sA:
3.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_1
(CYTOCHROME P450 3A4)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 PHE A 781
ILE A 810
PHE A 846
ALA A 843
THR A 855
 None
 1.21A 5vcgA-3s1sA:
undetectable		 5vcgA-3s1sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 6 LEU A 470
ARG A 481
LEU A 568
VAL A 525
 None
 0.88A 5x7zA-3s1sA:
undetectable		 5x7zA-3s1sA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 ALA A 329
GLY A 331
GLY A 333
ASN A 406
PHE A 447
 SAH  A 900 (-3.2A)
SAH  A 900 (-3.2A)
SAH  A 900 ( 4.5A)
SAH  A 900 (-4.5A)
None
 0.71A 5ybbA-3s1sA:
18.9		 5ybbA-3s1sA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 8 GLU A 204
ARG A 211
THR A 219
PRO A 218
 EDO  A 910 (-3.4A)
None
None
IOD  A 933 (-4.0A)
 1.06A 6a4iA-3s1sA:
undetectable		 6a4iA-3s1sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 7 ARG A 271
GLU A 204
ARG A 211
THR A 219
PRO A 218
 None
EDO  A 910 (-3.4A)
None
None
IOD  A 933 (-4.0A)
 1.45A 6a4iB-3s1sA:
undetectable		 6a4iB-3s1sA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GIQ_A_CUA601_0
(CYTOCHROME C OXIDASE
SUBUNIT 1)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		3 / 3 HIS A  26
HIS A  51
HIS A  50
 None
None
EDO  A 915 (-3.8A)
 0.69A 6giqa-3s1sA:
undetectable		 6giqa-3s1sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		5 / 12 VAL A 404
VAL A 402
SER A 308
SER A 311
PHE A 343
 None
 1.38A 6h7mB-3s1sA:
undetectable		 6h7mB-3s1sA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 8 ASP A  60
HIS A  51
GLU A 499
GLU A 302
 MN  A 930 (-2.5A)
None
None
None
 1.20A 6mn4C-3s1sA:
undetectable		 6mn4C-3s1sA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_E_AM2E301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3s1s RESTRICTION
ENDONUCLEASE BPUSI
(Bacillus
pumilus) 		4 / 7 HIS A 284
THR A 288
ARG A  90
GLU A 281
 SAH  A 900 ( 4.6A)
None
None
None
 1.15A 6mn4E-3s1sA:
undetectable		 6mn4E-3s1sA:
15.95