SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA502_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 6 PHE A  49
ASN A 298
ILE A  88
GLY A  47
 None
 0.99A 1oniA-3s25A:
undetectable
1oniB-3s25A:
undetectable		 1oniA-3s25A:
19.27
1oniB-3s25A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI518_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 7 ILE A  88
GLY A  47
PHE A  49
ASN A 298
 None
 1.01A 1oniG-3s25A:
undetectable
1oniI-3s25A:
undetectable		 1oniG-3s25A:
19.27
1oniI-3s25A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE210_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		5 / 9 LEU A 276
GLN A 268
SER A 311
GLU A 293
ALA A 275
 None
 1.33A 1wrlE-3s25A:
undetectable
1wrlF-3s25A:
undetectable		 1wrlE-3s25A:
12.08
1wrlF-3s25A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_B_MMZB501_1
(MONOOXYGENASE)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		3 / 3 ASN A 298
TYR A  87
SER A  59
 None
 0.90A 2gvcB-3s25A:
undetectable		 2gvcB-3s25A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GVC_E_MMZE501_1
(MONOOXYGENASE)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		3 / 3 ASN A 298
TYR A  87
SER A  59
 None
 0.85A 2gvcE-3s25A:
undetectable		 2gvcE-3s25A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 6 THR A  61
TYR A 303
MET A  70
THR A 307
 None
None
None
EDO  A 333 ( 4.5A)
 1.02A 2qmjA-3s25A:
undetectable		 2qmjA-3s25A:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 7 VAL A  35
ASP A  53
ILE A 164
ASN A  31
 EDO  A 332 (-4.5A)
EDO  A 332 (-2.9A)
None
None
 1.04A 3avpA-3s25A:
undetectable		 3avpA-3s25A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PO7_A_ZONA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 8 TYR A 216
PHE A 178
TYR A  44
TYR A 258
 None
EDO  A 335 (-4.3A)
EDO  A 334 (-4.4A)
EDO  A 334 (-3.5A)
 1.32A 3po7A-3s25A:
undetectable		 3po7A-3s25A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 5 TYR A  97
SER A 117
ASP A  91
ILE A 164
 None
 1.39A 3uj7B-3s25A:
undetectable		 3uj7B-3s25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 5 TYR A 216
LYS A 217
PRO A 218
TYR A  44
 None
None
None
EDO  A 334 (-4.4A)
 1.20A 4w5qA-3s25A:
undetectable		 4w5qA-3s25A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 6 TYR A 216
LYS A 217
PRO A 218
TYR A  44
 None
None
None
EDO  A 334 (-4.4A)
 1.26A 4z4cA-3s25A:
undetectable		 4z4cA-3s25A:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TDZ_A_ADNA905_1
(ATP-CITRATE SYNTHASE)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 6 THR A 202
ASP A 201
ARG A 185
ASP A 184
 None
 1.16A 5tdzA-3s25A:
undetectable		 5tdzA-3s25A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 5 ILE A 325
PHE A 306
ASN A 254
TYR A 267
 None
 1.05A 6a93B-3s25A:
undetectable		 6a93B-3s25A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_C_ACTC609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3s25 HYPOTHETICAL
7-BLADED
BETA-PROPELLER-LIKE
PROTEIN
([Eubacterium]
rectale) 		4 / 5 PHE A 309
GLU A 293
PHE A 294
ASP A 308
 None
 0.99A 6b58C-3s25A:
1.1		 6b58C-3s25A:
17.88