SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s2j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMJ_A_RTLA401_0
(RETINOL DEHYDRATASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 11 LEU A 201
HIS A 150
HIS A 212
ILE A 225
PHE A 248
 None
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.3A)
None
L3A  A 401 (-4.4A)
 1.50A 1fmjA-3s2jA:
0.0		 1fmjA-3s2jA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 8 LEU A  35
LEU A  23
LEU A  55
SER A 118
 None
 1.04A 1hk2A-3s2jA:
undetectable		 1hk2A-3s2jA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE9_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 233
LEU A 230
VAL A 229
SER A 213
VAL A 208
 None
 1.39A 1ie9A-3s2jA:
undetectable		 1ie9A-3s2jA:
21.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ASP A  22
GLU A 123
HIS A 191
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.33A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		9 / 12 ASP A  22
TYR A  68
GLU A 123
HIS A 150
HIS A 191
HIS A 212
ARG A 223
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.2A)
ZN  A 403 ( 3.3A)
L3A  A 401 (-4.0A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 0.44A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_A_CILA451_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		6 / 12 TYR A  68
GLU A 123
HIS A 150
HIS A  20
ASP A 320
PRO A 325
 L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.17A 1ituA-3s2jA:
57.9		 1ituA-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ASP A  22
GLU A 123
HIS A 191
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.31A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		9 / 12 ASP A  22
TYR A  68
GLU A 123
HIS A 150
HIS A 191
HIS A 212
ARG A 223
ASP A 320
PRO A 325
 ZN  A 402 ( 2.2A)
L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 403 ( 3.2A)
ZN  A 403 ( 3.3A)
L3A  A 401 (-4.0A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 0.45A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 GLU A 123
HIS A 191
HIS A  20
ASP A 320
VAL A 245
 ZN  A 402 (-2.4A)
ZN  A 403 ( 3.2A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
None
 1.43A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ITU_B_CILB452_1
(RENAL DIPEPTIDASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		6 / 12 TYR A  68
GLU A 123
HIS A 150
HIS A  20
ASP A 320
PRO A 325
 L3A  A 401 ( 3.6A)
ZN  A 402 (-2.4A)
EDO  A 409 ( 3.7A)
ZN  A 402 ( 3.3A)
L3A  A 401 (-3.1A)
EDO  A 407 (-4.2A)
 1.16A 1ituB-3s2jA:
57.9		 1ituB-3s2jA:
41.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 HIS A 302
SER A 214
ASN A 224
ARG A 291
VAL A 245
 None
 1.43A 2o7oA-3s2jA:
undetectable		 2o7oA-3s2jA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA508_0
(CHORISMATE SYNTHASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 5 LEU A  27
ASP A 322
ALA A  26
ILE A  40
 None
EDO  A 407 (-3.7A)
EDO  A 407 ( 4.1A)
None
 0.92A 2qhfA-3s2jA:
undetectable		 2qhfA-3s2jA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPV_A_MIYA1209_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 HIS A 302
SER A 214
ASN A 224
ARG A 291
VAL A 245
 None
 1.34A 2xpvA-3s2jA:
undetectable		 2xpvA-3s2jA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 HIS A 302
SER A 214
ASN A 224
ARG A 291
VAL A 245
 None
 1.44A 2xpwA-3s2jA:
undetectable		 2xpwA-3s2jA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		3 / 3 ARG A   8
ASP A 333
ASN A 339
 None
 0.73A 2zzmA-3s2jA:
undetectable		 2zzmA-3s2jA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 354
LEU A 345
ILE A 317
SER A   3
VAL A 296
 None
 1.22A 3aqiB-3s2jA:
undetectable		 3aqiB-3s2jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHX_B_PXLB313_1
(PYRIDOXAL KINASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 8 SER A 214
VAL A 218
VAL A 242
THR A 298
 None
None
None
EDO  A 405 ( 4.4A)
 1.13A 3fhxB-3s2jA:
2.8		 3fhxB-3s2jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 LEU A 354
LEU A 345
ILE A 317
SER A   3
VAL A 296
 None
 1.29A 3w1wA-3s2jA:
undetectable		 3w1wA-3s2jA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 HIS A 212
SER A  66
ASP A 333
ASP A  22
 ZN  A 403 ( 3.3A)
ZN  A 402 ( 3.9A)
None
ZN  A 402 ( 2.2A)
 1.32A 4blvA-3s2jA:
undetectable		 4blvA-3s2jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ASP A 188
GLY A 121
GLY A  19
SER A 211
GLY A 125
 None
 0.90A 4blvB-3s2jA:
undetectable		 4blvB-3s2jA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF3_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 12 ALA A 362
ALA A  62
VAL A  17
ASP A 106
ALA A 105
 None
 1.39A 4df3B-3s2jA:
undetectable		 4df3B-3s2jA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		6 / 12 LEU A 357
LEU A 354
LEU A 345
ILE A 317
SER A   3
VAL A 296
 None
 1.30A 4f4dB-3s2jA:
undetectable		 4f4dB-3s2jA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		5 / 10 LEU A 357
LEU A 354
LEU A 345
ILE A 317
VAL A 296
 None
 1.16A 4mk4A-3s2jA:
undetectable		 4mk4A-3s2jA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_1
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		3 / 3 SER A 211
TYR A 145
ASP A  22
 None
None
ZN  A 402 ( 2.2A)
 0.77A 4rp8C-3s2jA:
undetectable		 4rp8C-3s2jA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 TYR A 145
ASP A 320
HIS A  20
ILE A 317
 None
L3A  A 401 (-3.1A)
ZN  A 402 ( 3.3A)
None
 1.00A 5ih0A-3s2jA:
undetectable		 5ih0A-3s2jA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_B_ACTB401_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT
N6-ADENOSINE-METHYLT
RANSFERASE SUBUNIT
METTL14)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 ARG A   8
LEU A  11
ARG A  12
ARG A  56
 None
 1.16A 5l6eA-3s2jA:
undetectable
5l6eB-3s2jA:
undetectable		 5l6eA-3s2jA:
21.68
5l6eB-3s2jA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 7 LEU A 186
SER A 190
ILE A 317
ASN A 361
 None
 0.97A 5n5dA-3s2jA:
undetectable		 5n5dA-3s2jA:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 LEU A 169
ARG A 174
VAL A 177
VAL A 187
 None
 0.90A 5x7zA-3s2jA:
undetectable		 5x7zA-3s2jA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 7 TRP A  25
SER A  66
HIS A 150
GLY A 124
 L3A  A 401 (-4.4A)
ZN  A 402 ( 3.9A)
EDO  A 409 ( 3.7A)
None
 1.06A 6btxA-3s2jA:
undetectable		 6btxA-3s2jA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3s2j DIPEPTIDASE
(Streptomyces
coelicolor) 		4 / 6 ASN A 151
ASP A 152
SER A  71
ARG A  70
 L3A  A 401 (-4.7A)
EDO  A 409 (-3.3A)
EDO  A 409 (-3.2A)
None
 1.10A 6dwdA-3s2jA:
undetectable
6dwdC-3s2jA:
undetectable		 6dwdA-3s2jA:
21.93
6dwdC-3s2jA:
21.93