SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s3f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		3 / 3 ARG A 193
ASP A 128
ASN A  70
 None
 0.80A 1nbhA-3s3fA:
undetectable		 1nbhA-3s3fA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		3 / 3 ARG A 193
ASP A 128
ASN A  70
 None
 0.81A 1nbhD-3s3fA:
undetectable		 1nbhD-3s3fA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_A_ADNA1216_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 11 GLY A 272
VAL A 274
GLU A  52
ASP A 269
HIS A  34
 None
None
1BO  A 308 ( 4.7A)
None
None
 1.33A 2ac7A-3s3fA:
undetectable
2ac7B-3s3fA:
undetectable		 2ac7A-3s3fA:
20.38
2ac7B-3s3fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AC7_B_ADNB1215_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 11 HIS A  34
GLY A 272
VAL A 274
GLU A  52
ASP A 269
 None
None
None
1BO  A 308 ( 4.7A)
None
 1.34A 2ac7A-3s3fA:
undetectable
2ac7B-3s3fA:
undetectable		 2ac7A-3s3fA:
20.38
2ac7B-3s3fA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		3 / 3 ASN A  74
ASN A 102
ARG A 281
 None
 0.71A 2rlcA-3s3fA:
undetectable		 2rlcA-3s3fA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		3 / 3 ARG A  86
ASP A 128
ASN A  70
 None
 0.72A 2zzmA-3s3fA:
undetectable		 2zzmA-3s3fA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 12 SER A 249
LEU A 144
CYH A 242
ASP A 210
GLY A 212
 None
 1.49A 4j7xA-3s3fA:
undetectable		 4j7xA-3s3fA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 12 SER A 249
LEU A 144
CYH A 242
ASP A 210
GLY A 212
 None
 1.46A 4j7xF-3s3fA:
undetectable		 4j7xF-3s3fA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTQ_A_FLPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 10 VAL A 285
VAL A 274
ILE A 273
LEU A 220
LEU A 255
 None
 1.47A 4jtqA-3s3fA:
undetectable		 4jtqA-3s3fA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		4 / 7 MET A 132
SER A 136
ALA A 140
LEU A 200
 None
 1.09A 4xk8A-3s3fA:
undetectable		 4xk8A-3s3fA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		4 / 6 ILE A 262
GLY A 108
ASN A 110
ILE A 258
 None
 0.94A 5j4nB-3s3fA:
undetectable		 5j4nB-3s3fA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		4 / 4 ARG A  86
PHE A  64
ASP A  66
LEU A 122
 None
 1.44A 5uhdC-3s3fA:
0.0		 5uhdC-3s3fA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D
(Drosophila
melanogaster) 		5 / 9 VAL A 117
HIS A 241
GLY A 245
ILE A 294
ASP A 256
 None
 1.34A 6c2mC-3s3fA:
undetectable		 6c2mC-3s3fA:
13.36