SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 6 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.99A 1ictB-3s3tA:
undetectable		 1ictB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 6 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.97A 2roxB-3s3tA:
undetectable		 2roxB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 8 ARG A   4
LEU A 111
ALA A  29
ALA A  34
 None
 0.96A 3ns1L-3s3tA:
undetectable		 3ns1L-3s3tA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 6 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.92A 4i89A-3s3tA:
undetectable		 4i89A-3s3tA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 6 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.93A 4ikiB-3s3tA:
undetectable		 4ikiB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 7 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.98A 4ikjA-3s3tA:
undetectable
4ikjB-3s3tA:
undetectable		 4ikjA-3s3tA:
22.44
4ikjB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 7 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.94A 4ikkA-3s3tA:
undetectable
4ikkB-3s3tA:
undetectable		 4ikkA-3s3tA:
22.44
4ikkB-3s3tA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_B_AERB602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		5 / 9 ILE A 143
VAL A 142
GLY A 115
THR A 130
VAL A 135
 None
None
ATP  A 501 (-3.2A)
ATP  A 501 (-3.6A)
None
 1.28A 4r20B-3s3tA:
undetectable		 4r20B-3s3tA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		5 / 12 VAL A 125
SER A 132
VAL A 144
GLY A 115
ALA A 116
 None
None
None
ATP  A 501 (-3.2A)
None
 1.35A 5iktB-3s3tA:
undetectable		 5iktB-3s3tA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY
(Lactobacillus
plantarum) 		4 / 6 LEU A  36
ALA A  83
LEU A  86
THR A  81
 None
 0.89A 5l4iA-3s3tA:
undetectable		 5l4iA-3s3tA:
22.44