SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s46'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_A_NCAA700_0
(EXOTOXIN A)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 7 HIS A  46
GLY A  45
ALA A  43
TYR A  44
 None
None
None
LLP  A  40 ( 4.6A)
 0.92A 1dmaA-3s46A:
undetectable		 1dmaA-3s46A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 325
GLY A 324
ILE A 313
VAL A 305
LEU A 317
 None
 1.20A 1r30A-3s46A:
5.9		 1r30A-3s46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 12 THR A 325
GLY A 324
ILE A 313
VAL A 305
LEU A 317
 None
 1.20A 1r30B-3s46A:
5.8		 1r30B-3s46A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_2
(POL POLYPROTEIN)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 216
ASP A  60
GLY A 161
ILE A 162
 None
 0.81A 1t7iB-3s46A:
undetectable		 1t7iB-3s46A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_2
(POL POLYPROTEIN)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 7 ALA A 216
ASP A  60
GLY A 161
ILE A 162
 None
 0.82A 1t7jB-3s46A:
undetectable		 1t7jB-3s46A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_0
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 12 ILE A 130
GLY A 135
ILE A 137
PHE A 184
ALA A 167
 KCX  A 129 ( 3.8A)
None
KCX  A 129 ( 4.5A)
None
None
 1.39A 1vq1A-3s46A:
undetectable		 1vq1A-3s46A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 10 PHE A 139
GLU A 146
LEU A 151
LEU A 152
ILE A 111
 KCX  A 129 ( 4.5A)
None
None
None
None
 0.91A 3kvrA-3s46A:
undetectable		 3kvrA-3s46A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 10 PHE A 139
GLU A 146
LEU A 151
LEU A 152
ILE A 111
 KCX  A 129 ( 4.5A)
None
None
None
None
 0.86A 3kvrB-3s46A:
undetectable		 3kvrB-3s46A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 5 LEU A 207
SER A 229
LEU A 235
PRO A 236
 None
 1.25A 3onnA-3s46A:
undetectable		 3onnA-3s46A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		4 / 5 GLY A 262
PRO A 303
THR A 314
THR A 266
 None
 1.14A 5h5fA-3s46A:
undetectable		 5h5fA-3s46A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 11 PHE A  62
LEU A  78
ILE A  22
MET A 219
MET A 223
 None
 1.31A 6fgcA-3s46A:
undetectable		 6fgcA-3s46A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 3s46 ALANINE RACEMASE
(Streptococcus
pneumoniae) 		5 / 12 VAL A 278
ILE A 313
VAL A 305
ILE A 304
CYH A 302
 None
 1.25A 6gsdA-3s46A:
undetectable		 6gsdA-3s46A:
13.97