SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CTR_A_TFPA153_1
(CALMODULIN)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 9 GLU A 336
GLU A 259
GLU A 233
ALA A 256
VAL A 276
 None
MG  A 402 (-2.7A)
MG  A 402 (-2.8A)
None
None
 1.32A 1ctrA-3s47A:
undetectable		 1ctrA-3s47A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		3 / 3 GLN A 285
ILE A 367
HIS A 324
 None
 0.63A 1fm9A-3s47A:
undetectable		 1fm9A-3s47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 10 ALA A  98
ILE A 367
GLY A 366
GLY A 104
THR A 290
 None
 1.10A 1k6cA-3s47A:
undetectable		 1k6cA-3s47A:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		3 / 3 GLN A 285
ILE A 367
HIS A 324
 None
 0.62A 1k74A-3s47A:
undetectable		 1k74A-3s47A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KI7_B_ID2B2_0
(THYMIDINE KINASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 GLU A 339
ILE A 144
ILE A 152
ALA A 125
GLU A 140
 None
 1.36A 1ki7B-3s47A:
undetectable		 1ki7B-3s47A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_A_FOLA605_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.02A 1qzfA-3s47A:
undetectable		 1qzfA-3s47A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_B_FOLB609_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.02A 1qzfB-3s47A:
undetectable		 1qzfB-3s47A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_C_FOLC613_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.03A 1qzfC-3s47A:
undetectable		 1qzfC-3s47A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_D_FOLD617_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.03A 1qzfD-3s47A:
undetectable		 1qzfD-3s47A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZF_E_FOLE621_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.03A 1qzfE-3s47A:
undetectable		 1qzfE-3s47A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.88A 1rx7A-3s47A:
undetectable		 1rx7A-3s47A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 7 GLY A 368
MET A  97
ILE A 362
PRO A 352
 None
 1.03A 1rxcC-3s47A:
undetectable		 1rxcC-3s47A:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
ASP A  65
LEU A  99
GLY A 104
LEU A 106
 None
 1.04A 2jfaB-3s47A:
undetectable		 2jfaB-3s47A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 9 PHE A 220
ALA A 221
VAL A 224
GLU A 225
 None
 0.54A 2vufA-3s47A:
undetectable		 2vufA-3s47A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 THR A 400
ASP A 207
LEU A 212
LEU A 244
GLU A 259
 None
MG  A 402 (-3.0A)
None
None
MG  A 402 (-2.7A)
 1.20A 2zw9B-3s47A:
undetectable		 2zw9B-3s47A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 GLN A 250
PHE A 220
ALA A 217
THR A 251
ASN A 215
 None
 1.31A 3aobC-3s47A:
undetectable		 3aobC-3s47A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 6 LEU A 212
VAL A 208
VAL A 188
ASP A 223
 None
 1.12A 3fwgA-3s47A:
undetectable		 3fwgA-3s47A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_B_PNNB301_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 GLY A  38
ASN A 322
GLY A  94
SER A  93
GLY A 288
 None
 1.06A 3huoB-3s47A:
undetectable		 3huoB-3s47A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 ASP A 313
SER A 312
HIS A  21
GLU A 233
 None
None
None
MG  A 402 (-2.8A)
 1.15A 3sg9B-3s47A:
undetectable		 3sg9B-3s47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 ASP A 313
SER A 312
HIS A  21
GLU A 336
 None
 1.08A 3sg9B-3s47A:
undetectable		 3sg9B-3s47A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 11 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.03A 3tqbA-3s47A:
undetectable		 3tqbA-3s47A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 GLY A 366
GLY A 368
GLU A 363
ALA A 107
LEU A 114
 None
 1.11A 3vywA-3s47A:
2.1		 3vywA-3s47A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 6 LEU A 212
VAL A 208
VAL A 188
ASP A 223
 None
 1.12A 3wrhE-3s47A:
undetectable		 3wrhE-3s47A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 6 LEU A 212
VAL A 208
VAL A 188
ASP A 223
 None
 1.12A 3wrjE-3s47A:
undetectable		 3wrjE-3s47A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 7 LEU A 106
ALA A  66
VAL A  11
ILE A 102
 None
 0.88A 3wsjB-3s47A:
undetectable		 3wsjB-3s47A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 GLY A 368
MET A  97
ILE A 362
PRO A 352
 None
 0.99A 4e1vA-3s47A:
undetectable		 4e1vA-3s47A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 7 GLY A 368
MET A  97
ILE A 362
PRO A 352
 None
 0.99A 4e1vB-3s47A:
undetectable		 4e1vB-3s47A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 GLY A 368
MET A  97
ILE A 362
PRO A 352
 None
 0.99A 4e1vH-3s47A:
undetectable		 4e1vH-3s47A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_A_RKEA401_1
(PROTON-GATED ION
CHANNEL)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 TYR A 183
ASP A 207
VAL A 224
LEU A 212
 None
MG  A 402 (-3.0A)
None
None
 0.96A 4f8hA-3s47A:
undetectable
4f8hB-3s47A:
undetectable		 4f8hA-3s47A:
21.50
4f8hB-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_B_RKEB401_1
(PROTON-GATED ION
CHANNEL)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 TYR A 183
ASP A 207
VAL A 224
LEU A 212
 None
MG  A 402 (-3.0A)
None
None
 0.94A 4f8hB-3s47A:
undetectable
4f8hC-3s47A:
undetectable		 4f8hB-3s47A:
21.50
4f8hC-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_C_RKEC401_1
(PROTON-GATED ION
CHANNEL)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 TYR A 183
ASP A 207
VAL A 224
LEU A 212
 None
MG  A 402 (-3.0A)
None
None
 0.94A 4f8hC-3s47A:
undetectable
4f8hD-3s47A:
undetectable		 4f8hC-3s47A:
21.50
4f8hD-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_D_RKED401_1
(PROTON-GATED ION
CHANNEL)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 TYR A 183
ASP A 207
VAL A 224
LEU A 212
 None
MG  A 402 (-3.0A)
None
None
 0.95A 4f8hD-3s47A:
undetectable
4f8hE-3s47A:
undetectable		 4f8hD-3s47A:
21.50
4f8hE-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 VAL A 224
LEU A 212
TYR A 183
ASP A 207
 None
None
None
MG  A 402 (-3.0A)
 0.95A 4f8hA-3s47A:
undetectable
4f8hE-3s47A:
undetectable		 4f8hA-3s47A:
21.50
4f8hE-3s47A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.94A 4fhbA-3s47A:
undetectable		 4fhbA-3s47A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G3R_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 6 LEU A 212
VAL A 208
VAL A 188
ASP A 223
 None
 1.15A 4g3rB-3s47A:
undetectable		 4g3rB-3s47A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.92A 4kjlA-3s47A:
undetectable		 4kjlA-3s47A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.95A 4pstA-3s47A:
undetectable		 4pstA-3s47A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.95A 4pthA-3s47A:
undetectable		 4pthA-3s47A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLG_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.10A 4qlgB-3s47A:
undetectable		 4qlgB-3s47A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.99A 4x5fA-3s47A:
undetectable		 4x5fA-3s47A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5F_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.01A 4x5fB-3s47A:
undetectable		 4x5fB-3s47A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 7 GLU A 336
ARG A 280
GLU A 233
ASP A 234
 None
MG  A 402 (-4.7A)
MG  A 402 (-2.8A)
None
 1.13A 4zz8A-3s47A:
undetectable		 4zz8A-3s47A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 0.97A 5z6jA-3s47A:
undetectable		 5z6jA-3s47A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZSF_A_6T0A910_0
(TOLL-LIKE RECEPTOR 7)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 7 THR A 400
ILE A 393
THR A 397
PHE A 213
 None
 0.95A 5zsfA-3s47A:
undetectable
5zsfB-3s47A:
undetectable		 5zsfA-3s47A:
11.22
5zsfB-3s47A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		4 / 8 ASN A 322
HIS A 282
GLU A 336
ARG A 280
 None
None
None
MG  A 402 (-4.7A)
 1.11A 6b94A-3s47A:
undetectable		 6b94A-3s47A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 VAL A  11
LEU A 111
VAL A 321
PHE A 115
THR A 290
 None
 1.34A 6brdA-3s47A:
undetectable		 6brdA-3s47A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 VAL A  53
GLY A 318
VAL A 321
PHE A 115
THR A 290
 None
 1.20A 6brdC-3s47A:
undetectable		 6brdC-3s47A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		3 / 3 ILE A  15
THR A  16
PRO A  46
 None
 0.49A 6ncsA-3s47A:
4.7		 6ncsA-3s47A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN
(Clostridium
beijerinckii) 		5 / 12 ALA A  66
THR A 290
ILE A 289
LEU A 111
THR A   6
 None
 1.05A 7dfrA-3s47A:
undetectable		 7dfrA-3s47A:
16.92