SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s48'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		5 / 12 LEU A  90
HIS A 182
SER A 130
ILE A 131
TYR A 126
 None
 1.03A 1ot7B-3s48A:
undetectable		 1ot7B-3s48A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		5 / 12 LEU A 196
ILE A 198
LEU A 217
VAL A 137
PHE A 159
 None
 1.34A 2qo6A-3s48A:
undetectable		 2qo6A-3s48A:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		3 / 3 GLU A 180
GLU A 100
ASN A 101
 None
 0.71A 3lp9B-3s48A:
undetectable
3lp9D-3s48A:
1.2		 3lp9B-3s48A:
26.64
3lp9D-3s48A:
26.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_D_9PLD501_1
(CYTOCHROME P450 2A6)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		5 / 10 VAL A 161
PHE A 187
PHE A 114
ILE A 131
PHE A 219
 None
 1.37A 3t3rD-3s48A:
undetectable		 3t3rD-3s48A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NNR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP2)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		5 / 10 TYR A 138
ASP A 136
VAL A 173
ILE A 185
LYS A 132
 None
 1.25A 4nnrB-3s48A:
undetectable		 4nnrB-3s48A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		4 / 5 LEU A 217
PHE A 159
ILE A 131
ILE A 150
 None
 0.98A 5dzk4-3s48A:
undetectable
5dzkg-3s48A:
undetectable
5dzkm-3s48A:
undetectable
5dzkn-3s48A:
undetectable		 5dzk4-3s48A:
3.85
5dzkg-3s48A:
20.81
5dzkm-3s48A:
20.10
5dzkn-3s48A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_2
(SCRFP-TAG,GP41)		 3s48 IRON-REGULATED
SURFACE DETERMINANT
PROTEIN H
(Staphylococcus
aureus) 		3 / 3 LYS A 157
TRP A 156
SER A  89
 None
 1.07A 5nwwA-3s48A:
undetectable		 5nwwA-3s48A:
20.20