SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s4l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.10A 1kiaA-3s4lA:
undetectable		 1kiaA-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.10A 1kiaB-3s4lA:
undetectable		 1kiaB-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIA_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.09A 1kiaC-3s4lA:
undetectable		 1kiaC-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 6 LEU A  62
LEU A 212
GLY A 209
ILE A 207
 None
 0.88A 1mt1G-3s4lA:
undetectable
1mt1J-3s4lA:
undetectable		 1mt1G-3s4lA:
11.62
1mt1J-3s4lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_K_AG2K7002_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 207
LEU A  62
LEU A 212
GLY A 209
 None
 0.88A 1mt1H-3s4lA:
undetectable
1mt1K-3s4lA:
undetectable		 1mt1H-3s4lA:
20.99
1mt1K-3s4lA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A  62
LEU A 212
GLY A 209
ILE A 207
 None
 0.89A 1n13A-3s4lA:
undetectable
1n13F-3s4lA:
undetectable		 1n13A-3s4lA:
11.62
1n13F-3s4lA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.09A 1nbhB-3s4lA:
undetectable		 1nbhB-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.14A 1nbiA-3s4lA:
undetectable		 1nbiA-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_B_SAMB1293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 TYR A  98
ILE A 156
GLY A  69
ALA A  96
GLY A 154
 None
 1.14A 1nbiB-3s4lA:
undetectable		 1nbiB-3s4lA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  50
ILE A  48
PHE A  58
LEU A 211
ILE A  39
 None
 1.23A 2f78B-3s4lA:
undetectable		 2f78B-3s4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_B_BEZB1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 9 LEU A  50
ILE A  48
PHE A  58
LEU A 211
ILE A  39
 None
 1.19A 2f7aB-3s4lA:
undetectable		 2f7aB-3s4lA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 MET A  59
PHE A  58
ALA A  42
LEU A  43
 None
 1.05A 2o01A-3s4lA:
undetectable		 2o01A-3s4lA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_E_AG2E671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 207
LEU A  62
LEU A 212
GLY A 209
 None
 0.84A 2qqcD-3s4lA:
undetectable
2qqcE-3s4lA:
undetectable		 2qqcD-3s4lA:
21.43
2qqcE-3s4lA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 ILE A 207
LEU A  62
LEU A 212
GLY A 209
 None
 0.86A 2qqcH-3s4lA:
undetectable
2qqcK-3s4lA:
undetectable		 2qqcH-3s4lA:
21.43
2qqcK-3s4lA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 TYR A  75
ARG A  90
HIS A 124
 None
None
CA  A 501 (-3.4A)
 1.16A 4fubA-3s4lA:
undetectable		 4fubA-3s4lA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 115
MET A 191
ARG A 194
 None
 0.84A 4lnwA-3s4lA:
undetectable		 4lnwA-3s4lA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 ILE A 115
MET A 191
ARG A 194
 None
 0.84A 4lnxA-3s4lA:
undetectable		 4lnxA-3s4lA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJ8_A_SUVA2001_1
(HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 SER A  95
VAL A 120
VAL A   9
MET A  24
HIS A  91
 None
None
None
None
CA  A 501 (-3.5A)
 1.40A 4zj8A-3s4lA:
undetectable		 4zj8A-3s4lA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FUK_A_SNPA1236_1
(MROUPO)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 7 ILE A 184
ILE A  68
ILE A 171
LEU A  65
 None
 0.80A 5fukA-3s4lA:
undetectable
5fukB-3s4lA:
undetectable		 5fukA-3s4lA:
19.85
5fukB-3s4lA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_D_ADND501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
HIS A 123
LEU A 212
GLY A 209
PHE A  58
 None
CA  A 501 (-3.5A)
None
None
None
 1.50A 5hm8D-3s4lA:
undetectable		 5hm8D-3s4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_E_ADNE501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
HIS A 123
LEU A 212
GLY A 209
PHE A  58
 None
CA  A 501 (-3.5A)
None
None
None
 1.49A 5hm8E-3s4lA:
undetectable		 5hm8E-3s4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_F_ADNF501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
HIS A 123
LEU A 212
GLY A 209
PHE A  58
 None
CA  A 501 (-3.5A)
None
None
None
 1.50A 5hm8F-3s4lA:
undetectable		 5hm8F-3s4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_G_ADNG501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
HIS A 123
LEU A 212
GLY A 209
PHE A  58
 None
CA  A 501 (-3.5A)
None
None
None
 1.50A 5hm8G-3s4lA:
undetectable		 5hm8G-3s4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HM8_H_ADNH501_1
(ADENOSYLHOMOCYSTEINA
SE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 LEU A  62
HIS A 123
LEU A 212
GLY A 209
PHE A  58
 None
CA  A 501 (-3.5A)
None
None
None
 1.50A 5hm8H-3s4lA:
undetectable		 5hm8H-3s4lA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HS6_A_J3ZA302_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE 14)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 HIS A 123
LEU A 212
LEU A 215
MET A  24
 CA  A 501 (-3.5A)
None
None
None
 1.02A 5hs6A-3s4lA:
undetectable		 5hs6A-3s4lA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		5 / 12 PHE A  58
LEU A 215
LEU A 212
THR A  99
ALA A  96
 None
 1.37A 5ieoA-3s4lA:
undetectable		 5ieoA-3s4lA:
24.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 THR A 119
MET A 121
HIS A 123
 None
None
CA  A 501 (-3.5A)
 0.94A 5uunA-3s4lA:
undetectable		 5uunA-3s4lA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 124
HIS A 123
HIS A  91
 CA  A 501 (-3.4A)
CA  A 501 (-3.5A)
CA  A 501 (-3.5A)
 0.49A 5zrdA-3s4lA:
undetectable		 5zrdA-3s4lA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		3 / 3 HIS A 123
HIS A 124
ARG A  90
 CA  A 501 (-3.5A)
CA  A 501 (-3.4A)
None
 1.09A 6b58A-3s4lA:
undetectable		 6b58A-3s4lA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBZ_A_ESTA601_1
(ESTROGEN RECEPTOR)		 3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE
(Methanocaldococc
us
jannaschii) 		4 / 8 LEU A 212
LEU A 118
HIS A  66
LEU A  62
 None
 1.28A 6cbzA-3s4lA:
undetectable		 6cbzA-3s4lA:
15.98