SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1dfoA-3s4oA:
undetectable		 1dfoA-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1dfoB-3s4oA:
undetectable		 1dfoB-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.95A 1dfoC-3s4oA:
undetectable		 1dfoC-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1dfoD-3s4oA:
undetectable		 1dfoD-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1eqbA-3s4oA:
undetectable		 1eqbA-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.96A 1eqbB-3s4oA:
undetectable		 1eqbB-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.95A 1eqbC-3s4oA:
undetectable		 1eqbC-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 LEU A  47
VAL A  60
ALA A 119
SER A  28
PRO A  27
 None
None
THJ  A 170 (-3.7A)
None
None
 0.95A 1eqbD-3s4oA:
undetectable		 1eqbD-3s4oA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		4 / 7 LEU A 127
ILE A 142
ILE A 158
ASP A 137
 None
 0.83A 1uwjA-3s4oA:
undetectable		 1uwjA-3s4oA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XF3_B_J01B500_1
(ORF12)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 9 VAL A  60
ILE A  36
LEU A  22
ARG A  42
GLY A  43
 None
None
None
None
EPE  A 164 (-3.5A)
 1.37A 2xf3B-3s4oA:
undetectable		 2xf3B-3s4oA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_B_J01B1436_1
(ORF12)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 9 VAL A  60
ILE A  36
LEU A  22
ARG A  42
GLY A  43
 None
None
None
None
EPE  A 164 (-3.5A)
 1.37A 2xh9B-3s4oA:
undetectable		 2xh9B-3s4oA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 ILE A 108
LEU A  90
HIS A  68
TRP A  70
GLY A 109
 None
 1.22A 5nnaA-3s4oA:
undetectable		 5nnaA-3s4oA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 ILE A 108
LEU A  90
HIS A  68
TRP A  70
GLY A 109
 None
 1.21A 5nnaB-3s4oA:
undetectable		 5nnaB-3s4oA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 ILE A 108
LEU A  90
HIS A  68
TRP A  70
GLY A 109
 None
 1.22A 5nnaC-3s4oA:
undetectable		 5nnaC-3s4oA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 ILE A 108
LEU A  90
HIS A  68
TRP A  70
GLY A 109
 None
 1.23A 5nnaD-3s4oA:
undetectable		 5nnaD-3s4oA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3s4o PROTEIN TYROSINE
PHOSPHATASE-LIKE
PROTEIN
(Leishmania
major) 		5 / 12 HIS A 111
LEU A  22
MET A   1
LEU A  32
TYR A  55
 None
 1.45A 5ycpA-3s4oA:
undetectable		 5ycpA-3s4oA:
20.50