SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTV_A_TESA500_1
(17
BETA-HYDROXYSTEROID
DEHYDROGENASE TYPE 1)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 PRO A  62
TYR A 142
SER A 131
GLU A 192
 SO4  A 349 ( 4.3A)
None
None
None
 1.22A 1jtvA-3s4tA:
undetectable		 1jtvA-3s4tA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 GLY A 316
ALA A 318
THR A 260
ILE A   5
 None
 0.85A 2dtjA-3s4tA:
undetectable
2dtjB-3s4tA:
undetectable		 2dtjA-3s4tA:
20.88
2dtjB-3s4tA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 5 PRO A 102
ALA A  73
ASP A 143
ASP A 133
 None
 0.92A 2nyuB-3s4tA:
undetectable		 2nyuB-3s4tA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_C_CHDC271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 7 LEU A 101
GLN A  65
PHE A 150
LEU A 113
 None
 0.95A 3asnC-3s4tA:
undetectable
3asnJ-3s4tA:
undetectable		 3asnC-3s4tA:
20.62
3asnJ-3s4tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 9 LEU A 283
THR A 260
GLY A 263
ALA A 296
ILE A  52
 None
 1.10A 3jusB-3s4tA:
undetectable		 3jusB-3s4tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_B_TOPB208_1
(DIHYDROFOLATE
REDUCTASE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 9 ALA A  99
VAL A 123
ILE A 215
LEU A 321
ILE A  56
 None
 1.27A 3jw3B-3s4tA:
undetectable		 3jw3B-3s4tA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 12 SER A  20
ALA A 100
PHE A  98
LEU A  57
ARG A  43
 None
 1.23A 4z7fC-3s4tA:
undetectable		 4z7fC-3s4tA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 ILE A   5
LEU A   7
LEU A 324
LEU A 283
 None
 0.81A 4zvcA-3s4tA:
undetectable
4zvcB-3s4tA:
undetectable		 4zvcA-3s4tA:
15.52
4zvcB-3s4tA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVC_A_BEZA301_0
(DIGUANYLATE CYCLASE
DOSC)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 283
ILE A   5
LEU A   7
LEU A 324
 None
 0.79A 4zvcA-3s4tA:
undetectable
4zvcB-3s4tA:
undetectable		 4zvcA-3s4tA:
15.52
4zvcB-3s4tA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 7 LEU A 101
GLN A  65
PHE A 150
LEU A 113
 None
 0.95A 5b1bP-3s4tA:
undetectable
5b1bW-3s4tA:
undetectable		 5b1bP-3s4tA:
20.62
5b1bW-3s4tA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 7 LEU A 321
PRO A 160
ILE A 214
LEU A 216
 None
 0.87A 5fxtA-3s4tA:
undetectable		 5fxtA-3s4tA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 11 LEU A 321
VAL A 159
TYR A 162
GLY A 124
LEU A   7
 None
 1.48A 5hbmA-3s4tA:
undetectable		 5hbmA-3s4tA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		3 / 3 ASP A 287
ASN A 292
PHE A  11
 None
ACT  A 353 (-3.6A)
None
 0.83A 5jglB-3s4tA:
undetectable		 5jglB-3s4tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 12 GLU A  15
ALA A  77
ALA A  12
ALA A  63
ALA A  61
 None
 0.99A 5zw4A-3s4tA:
undetectable		 5zw4A-3s4tA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 GLY A  51
ILE A  52
ASP A 298
ASP A 294
 None
None
None
ACT  A 353 (-3.3A)
 1.04A 6ag0C-3s4tA:
4.1		 6ag0C-3s4tA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BSI_A_EFZA601_1
(REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		5 / 10 LEU A 321
VAL A 159
TYR A 162
GLY A 124
LEU A   7
 None
 1.47A 6bsiA-3s4tA:
undetectable		 6bsiA-3s4tA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 3s4t AMIDOHYDROLASE 2
(Polaromonas
sp.
JS666) 		4 / 8 LEU A 212
TYR A 209
GLU A 152
TRP A 151
 None
 1.21A 6c71B-3s4tA:
undetectable		 6c71B-3s4tA:
12.35