SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 8 TYR A 228
PHE A 246
PHE A   9
LEU A 241
 None
 1.27A 1ea1A-3s4uA:
2.6		 1ea1A-3s4uA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 7 PHE A  81
PHE A 246
PHE A 224
LEU A   7
 None
 1.07A 1qcaA-3s4uA:
undetectable		 1qcaA-3s4uA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 8 ILE A 144
PHE A 149
LEU A 108
LEU A 111
 None
 0.90A 2w98B-3s4uA:
undetectable		 2w98B-3s4uA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 8 SER A  95
VAL A 138
TYR A  93
ASN A 122
 None
 1.10A 2wekA-3s4uA:
undetectable		 2wekA-3s4uA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 8 SER A  95
VAL A 138
TYR A  93
ASN A 122
 None
 1.15A 2wekB-3s4uA:
undetectable		 2wekB-3s4uA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_C_QPSC1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		5 / 12 PHE A 131
SER A 127
SER A 129
ASN A 174
GLY A 121
 None
 1.24A 2x2iC-3s4uA:
undetectable		 2x2iC-3s4uA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		5 / 9 ASP A  46
ILE A  50
GLY A  49
VAL A 208
ARG A 258
 None
 1.23A 4acaB-3s4uA:
undetectable
4acaC-3s4uA:
2.3		 4acaB-3s4uA:
22.74
4acaC-3s4uA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 5 ASN A  66
PRO A 206
GLY A 204
ASP A 223
 None
 0.92A 4n48B-3s4uA:
undetectable		 4n48B-3s4uA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		5 / 12 GLY A 204
ASP A 205
PHE A 225
PHE A  81
PHE A 246
 None
 1.16A 4wh5A-3s4uA:
undetectable		 4wh5A-3s4uA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		3 / 3 THR A 159
ALA A 155
ASN A 160
 None
 0.62A 5ersA-3s4uA:
2.2		 5ersA-3s4uA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_B_PFLB407_1
(PROTON-GATED ION
CHANNEL)		 3s4u PHND, SUBUNIT OF
ALKYLPHOSPHONATE ABC
TRANSPORTER
(Escherichia
coli) 		4 / 7 TYR A  47
ILE A  50
ILE A  51
MET A  54
 None
 0.94A 5murB-3s4uA:
2.5		 5murB-3s4uA:
11.76