SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s4w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 8 LEU B 303
LEU B 378
LEU B 454
LEU B 415
 None
 0.96A 1dvtA-3s4wB:
undetectable
1dvtB-3s4wB:
undetectable		 1dvtA-3s4wB:
6.02
1dvtB-3s4wB:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 9 VAL B 225
LEU B 217
ILE B 210
SER B 249
LEU B 250
 None
 1.16A 1eqgA-3s4wB:
undetectable		 1eqgA-3s4wB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_A_FLPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 VAL B 246
LEU B 229
ILE B 216
GLY B 218
LEU B 250
 None
 0.99A 1eqhA-3s4wB:
undetectable		 1eqhA-3s4wB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQH_B_FLPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 VAL B 246
LEU B 229
ILE B 216
GLY B 218
LEU B 250
 None
 0.99A 1eqhB-3s4wB:
undetectable		 1eqhB-3s4wB:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_B_ESTB354_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 8 VAL B 246
LEU B 229
PRO B 242
MET B 195
 None
 0.93A 1fduB-3s4wB:
undetectable		 1fduB-3s4wB:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 10 LEU B1184
GLU B1239
LEU B1180
ALA B1157
LEU B1130
 None
 1.31A 1ie4A-3s4wB:
undetectable
1ie4C-3s4wB:
undetectable		 1ie4A-3s4wB:
8.05
1ie4C-3s4wB:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 LEU B 133
THR B 102
GLN B 157
MET B 170
 None
 1.11A 1kglA-3s4wB:
undetectable		 1kglA-3s4wB:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 PHE B 797
PHE B 731
VAL B 663
PHE B 658
THR B 786
 None
 1.17A 1q23B-3s4wB:
undetectable		 1q23B-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 4 ALA B 580
VAL B 577
ALA B 576
HIS B 554
 None
 1.15A 1q23A-3s4wB:
undetectable		 1q23A-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 4 ALA B 580
VAL B 577
ALA B 576
HIS B 554
 None
 1.16A 1q23F-3s4wB:
undetectable		 1q23F-3s4wB:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 6 LEU B 727
LEU B 757
TRP B 789
PHE B 790
 None
 1.44A 1ru9H-3s4wB:
undetectable
1ru9L-3s4wB:
undetectable		 1ru9H-3s4wB:
10.28
1ru9L-3s4wB:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_L_ACTL611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 6 LEU B 727
LEU B 757
TRP B 789
PHE B 790
 None
 1.49A 1rukH-3s4wB:
undetectable
1rukL-3s4wB:
undetectable		 1rukH-3s4wB:
10.28
1rukL-3s4wB:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 LEU B 967
LEU B 934
GLY B 959
SER B 936
ALA B 961
 None
 1.13A 2bm9D-3s4wB:
undetectable		 2bm9D-3s4wB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_B_SC2B1290_1
(FICOLIN-2)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 8 LEU B 534
LEU B 516
ASP B 552
ASP B 551
 None
 0.98A 2j2pA-3s4wB:
undetectable
2j2pB-3s4wB:
undetectable		 2j2pA-3s4wB:
10.26
2j2pB-3s4wB:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 LEU B 173
ASN B 176
LEU B 178
LEU B 197
LEU B 205
 None
 1.48A 2oaxA-3s4wB:
undetectable		 2oaxA-3s4wB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_1
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		3 / 3 GLN B 741
THR B 653
TRP B 649
 None
 1.05A 2rctA-3s4wB:
undetectable		 2rctA-3s4wB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_B_VD3B2001_1
(VITAMIN D
HYDROXYLASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 11 LEU B 537
ASN B 508
MET B 505
LEU B 495
THR B 578
 None
 1.40A 3a50B-3s4wB:
2.7		 3a50B-3s4wB:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 10 GLU B 360
ILE B 352
ARG B 300
LEU B 303
ILE B 296
 None
 1.19A 3adsA-3s4wB:
undetectable		 3adsA-3s4wB:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 VAL B 565
GLN B 560
GLY B 575
LEU B 611
 None
 0.91A 3bjwB-3s4wB:
undetectable		 3bjwB-3s4wB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 6 VAL B 565
GLN B 560
GLY B 575
LEU B 611
 None
 0.98A 3bjwE-3s4wB:
undetectable		 3bjwE-3s4wB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 VAL B 565
GLN B 560
GLY B 575
LEU B 611
 None
 0.85A 3bjwH-3s4wB:
undetectable		 3bjwH-3s4wB:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 10 ILE B 366
ALA B 365
ALA B 297
ILE B 410
CYH B 409
 None
 1.13A 3falA-3s4wB:
undetectable		 3falA-3s4wB:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 9 MET B 579
LEU B 561
ILE B 571
LEU B 519
PHE B 531
 None
 1.32A 3fl9D-3s4wB:
undetectable		 3fl9D-3s4wB:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 9 MET B 150
LEU B 112
ILE B 175
LEU B 178
THR B 102
 None
 1.32A 3fl9H-3s4wB:
undetectable		 3fl9H-3s4wB:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_A_NCAA192_0
(NICOTINAMIDASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 11 PHE B 451
LEU B 415
PHE B 419
LEU B 455
ILE B 433
 None
 1.47A 3o94A-3s4wB:
undetectable		 3o94A-3s4wB:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_C_NCAC192_0
(NICOTINAMIDASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 11 PHE B 451
LEU B 415
PHE B 419
LEU B 455
ILE B 433
 None
 1.49A 3o94C-3s4wB:
undetectable		 3o94C-3s4wB:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O94_D_NCAD192_0
(NICOTINAMIDASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 11 PHE B 451
LEU B 415
PHE B 419
LEU B 455
ILE B 433
 None
 1.48A 3o94D-3s4wB:
undetectable		 3o94D-3s4wB:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		3 / 3 ASN B 795
GLU B 792
ARG B 791
 None
 1.07A 3wxoA-3s4wB:
1.0		 3wxoA-3s4wB:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 10 ALA B 201
PRO B 242
ILE B 243
LEU B 229
ILE B 210
 None
 1.19A 4dtaA-3s4wB:
2.1		 4dtaA-3s4wB:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 8 LEU B 813
ARG B 791
VAL B 794
VAL B 930
 None
 0.95A 4em2A-3s4wB:
undetectable		 4em2A-3s4wB:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 ILE B 147
LEU B 112
LYS B 135
ILE B 175
ASN B 176
 None
 1.24A 4gh8B-3s4wB:
undetectable		 4gh8B-3s4wB:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 VAL B  45
LEU B 137
VAL B  90
LEU B  81
SER B  53
 None
 1.05A 4po0A-3s4wB:
2.6		 4po0A-3s4wB:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_A_HQEA503_1
(CATALASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 9 ILE B 429
PHE B 419
LEU B 426
LEU B 455
PHE B 451
 None
 1.44A 4qopA-3s4wB:
undetectable		 4qopA-3s4wB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOP_B_HQEB503_1
(CATALASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 9 ILE B 429
PHE B 419
LEU B 426
LEU B 455
PHE B 451
 None
 1.44A 4qopB-3s4wB:
undetectable		 4qopB-3s4wB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 PHE B  73
THR B 102
LEU B 143
LEU B  57
LEU B  50
 None
 1.43A 4qynB-3s4wB:
undetectable		 4qynB-3s4wB:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 VAL B1270
ASN B1267
LEU B1263
LEU B1304
LEU B1364
 None
 1.45A 4rtbA-3s4wB:
undetectable		 4rtbA-3s4wB:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 6 LEU B1276
LEU B1209
PHE B1283
VAL B1288
 None
 0.75A 4udaA-3s4wB:
undetectable		 4udaA-3s4wB:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 7 GLU B 360
ILE B 352
ARG B 300
LEU B 303
ILE B 296
 None
 1.13A 4xumA-3s4wB:
undetectable		 4xumA-3s4wB:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_B_HFGB802_0
(PROLINE--TRNA LIGASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 PHE B1176
THR B1225
GLU B1208
SER B1219
GLY B1205
 None
 1.43A 4ydqB-3s4wB:
undetectable		 4ydqB-3s4wB:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 ILE B 573
CYH B 618
LEU B 561
GLY B 572
 None
 0.84A 5a06A-3s4wB:
undetectable		 5a06A-3s4wB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 ILE B 573
CYH B 618
LEU B 561
GLY B 572
 None
 0.83A 5a06C-3s4wB:
undetectable		 5a06C-3s4wB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 ILE B 573
CYH B 618
LEU B 561
GLY B 572
 None
 0.85A 5a06E-3s4wB:
undetectable		 5a06E-3s4wB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 7 ILE B 573
CYH B 618
LEU B 561
GLY B 572
 None
 0.84A 5a06F-3s4wB:
undetectable		 5a06F-3s4wB:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 5 ALA B 576
HIS B 554
MET B 583
LEU B 614
 None
 1.44A 5dzkf-3s4wB:
2.7
5dzkt-3s4wB:
undetectable		 5dzkf-3s4wB:
9.61
5dzkt-3s4wB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 6 LEU B 133
THR B 102
GLN B 157
MET B 170
 None
 1.22A 5h8tA-3s4wB:
undetectable		 5h8tA-3s4wB:
7.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		4 / 8 ILE B 296
ILE B 348
ALA B 351
ILE B 352
 None
 0.57A 5mvmA-3s4wB:
3.0
5mvmB-3s4wB:
3.0		 5mvmA-3s4wB:
4.39
5mvmB-3s4wB:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND3_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 VAL B 694
LEU B 762
LEU B 681
ALA B 680
PRO B 670
 None
 1.04A 5nd3B-3s4wB:
undetectable		 5nd3B-3s4wB:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_D_CUD603_0
(THIOCYANATE
DEHYDROGENASE)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		3 / 3 LYS B1294
HIS B1354
HIS B1290
 None
 1.41A 5oexD-3s4wB:
undetectable		 5oexD-3s4wB:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_B_TA1B501_1
(TUBULIN BETA CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 ASP B 141
LEU B  55
LEU B  66
LEU B  50
LEU B  81
 None
 1.00A 6ew0B-3s4wB:
undetectable		 6ew0B-3s4wB:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_D_TA1D501_1
(TUBULIN BETA CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 ASP B 141
LEU B  55
LEU B  66
LEU B  50
LEU B  81
 None
 0.99A 6ew0D-3s4wB:
undetectable		 6ew0D-3s4wB:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_H_TA1H501_1
(TUBULIN BETA CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 ASP B 141
LEU B  55
LEU B  66
LEU B  50
LEU B  81
 None
 1.00A 6ew0H-3s4wB:
undetectable		 6ew0H-3s4wB:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_I_TA1I501_1
(TUBULIN BETA CHAIN)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		5 / 12 ASP B 141
LEU B  55
LEU B  66
LEU B  50
LEU B  81
 None
 0.99A 6ew0I-3s4wB:
undetectable		 6ew0I-3s4wB:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		3 / 3 LYS B 723
SER B 729
SER B 627
 None
 0.75A 6gbfA-3s4wB:
undetectable		 6gbfA-3s4wB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG
(Mus
musculus) 		3 / 3 THR B 191
GLU B 231
ASN B 224
 None
 0.76A 6nj9K-3s4wB:
undetectable		 6nj9K-3s4wB:
15.20