SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s52'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 12 THR A 161
PRO A 192
ILE A  71
VAL A  98
LEU A 208
 None
 1.20A 1z9hD-3s52A:
undetectable		 1z9hD-3s52A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		4 / 8 ASP A 101
LYS A 122
GLY A 190
GLU A  72
 None
SO4  A 219 (-3.1A)
None
None
 0.90A 2ys6A-3s52A:
undetectable		 2ys6A-3s52A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 11 ARG A 105
VAL A  58
PRO A  57
PRO A 129
ILE A  71
 None
 1.35A 3ganA-3s52A:
undetectable		 3ganA-3s52A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 11 ILE A  60
THR A 215
ILE A 206
LEU A 100
VAL A  58
 None
 1.13A 3n0hA-3s52A:
undetectable		 3n0hA-3s52A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 11 ILE A 134
ALA A 137
PHE A 139
ILE A 168
LEU A  73
 None
 1.10A 3n0hA-3s52A:
undetectable		 3n0hA-3s52A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QF1_A_PZEA6951_1
(LACTOPEROXIDASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		3 / 3 HIS A  68
ARG A 105
GLU A 106
 None
 0.94A 3qf1A-3s52A:
undetectable		 3qf1A-3s52A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		4 / 7 GLY A 126
ALA A  50
VAL A  19
ILE A  54
 None
 0.76A 3t3cA-3s52A:
undetectable		 3t3cA-3s52A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 9 VAL A 195
ILE A 130
VAL A  98
ALA A  74
THR A 189
 None
 1.26A 4oqrA-3s52A:
undetectable		 4oqrA-3s52A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		4 / 8 THR A 191
PRO A 192
LEU A 100
SER A 148
 None
 0.90A 4qknA-3s52A:
undetectable		 4qknA-3s52A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 9 GLY A  97
ALA A  74
VAL A  19
ILE A  54
ILE A 186
 None
 0.92A 4rvjB-3s52A:
undetectable		 4rvjB-3s52A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		5 / 9 GLY A  97
ALA A  74
VAL A  19
ILE A  54
ILE A 186
 None
 0.92A 4rvjD-3s52A:
undetectable		 4rvjD-3s52A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		4 / 4 ILE A 206
GLY A  97
ILE A  54
LEU A 208
 None
 0.90A 5dzkl-3s52A:
undetectable
5dzkz-3s52A:
undetectable		 5dzkl-3s52A:
24.57
5dzkz-3s52A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s52 PUTATIVE
FUMARYLACETOACETATE
HYDROLASE FAMILY
PROTEIN
(Yersinia
pestis) 		6 / 12 VAL A  19
TYR A   2
LEU A 208
GLY A  97
ALA A  74
LEU A 188
 None
 1.40A 5iktA-3s52A:
undetectable		 5iktA-3s52A:
18.18