SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s55'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_2
(HIV-1 PROTEASE)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 9 ALA A 183
ASP A 185
GLY A 177
ILE A 176
VAL A 151
 None
 1.09A 1hpvB-3s55A:
undetectable		 1hpvB-3s55A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		3 / 3 ALA A 183
HIS A 184
VAL A 187
 None
 0.51A 1lqtB-3s55A:
5.2		 1lqtB-3s55A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		3 / 3 ALA A 183
HIS A 184
VAL A 187
 None
 0.51A 1lquB-3s55A:
4.8		 1lquB-3s55A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		4 / 5 GLY A 174
ILE A 176
VAL A 169
SER A 154
 None
 1.25A 1rs7A-3s55A:
undetectable		 1rs7A-3s55A:
20.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		6 / 11 GLY A  14
ALA A  16
ASP A  38
ASP A  76
VAL A  77
ALA A 104
 NAD  A 279 (-3.4A)
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.9A)
NAD  A 279 (-3.6A)
NAD  A 279 (-3.6A)
NAD  A 279 (-3.6A)
 0.29A 1uayA-3s55A:
30.0		 1uayA-3s55A:
32.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		6 / 10 GLY A  14
ALA A  16
ASP A  38
ASP A  76
VAL A  77
ALA A 104
 NAD  A 279 (-3.4A)
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.9A)
NAD  A 279 (-3.6A)
NAD  A 279 (-3.6A)
NAD  A 279 (-3.6A)
 0.27A 1uayB-3s55A:
30.3		 1uayB-3s55A:
32.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A8T_B_ADNB252_1
(U8 SNORNA-BINDING
PROTEIN X29)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		4 / 8 GLY A 158
THR A 131
ILE A 176
SER A 154
 None
 1.00A 2a8tB-3s55A:
undetectable		 2a8tB-3s55A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A  14
ASP A  38
ASP A  76
ASN A 103
ALA A 104
 NAD  A 279 (-3.4A)
NAD  A 279 (-2.9A)
NAD  A 279 (-3.6A)
NAD  A 279 (-3.3A)
NAD  A 279 (-3.6A)
 0.98A 2bm9E-3s55A:
4.6		 2bm9E-3s55A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_B_BEZB1162_0
(PEROXIREDOXIN-5)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		4 / 7 THR A 126
GLY A 105
LEU A  83
THR A  13
 NAD  A 279 (-3.1A)
NAD  A 279 (-3.6A)
None
None
 0.96A 2vl2B-3s55A:
undetectable		 2vl2B-3s55A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 THR A  59
GLY A  15
ASP A  55
ILE A  34
THR A  66
 None
 1.10A 3eeyC-3s55A:
8.5		 3eeyC-3s55A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_F_SAMF300_0
(PUTATIVE RRNA
METHYLASE)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 THR A  59
GLY A  15
ASP A  55
ILE A  34
THR A  66
 None
 1.08A 3eeyF-3s55A:
3.5		 3eeyF-3s55A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		4 / 5 ASN A 162
ASN A 200
HIS A 235
ALA A 273
 None
 1.13A 3frqA-3s55A:
undetectable		 3frqA-3s55A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 GLY A 199
ASN A 103
SER A  22
GLY A  14
PRO A 204
 None
NAD  A 279 (-3.3A)
None
NAD  A 279 (-3.4A)
NAD  A 279 (-3.8A)
 1.06A 4fp9C-3s55A:
6.7		 4fp9C-3s55A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_F_SAMF301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 THR A  93
GLY A  96
GLY A  95
LEU A  94
ALA A 137
 None
 0.98A 5c0oF-3s55A:
5.2		 5c0oF-3s55A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 9 THR A  13
VAL A  77
GLY A 130
THR A 131
VAL A 153
 None
NAD  A 279 (-3.6A)
None
None
NAD  A 279 (-4.8A)
 1.38A 5cp4A-3s55A:
undetectable		 5cp4A-3s55A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3s55 PUTATIVE SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE
(Mycobacteroides
abscessus) 		5 / 12 CYH A  37
ALA A  16
ASP A  38
ASP A  76
LEU A  83
 None
NAD  A 279 ( 4.0A)
NAD  A 279 (-2.9A)
NAD  A 279 (-3.6A)
None
 1.11A 5wwsA-3s55A:
7.2		 5wwsA-3s55A:
20.79