SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_A_LPRA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.83A 1j36A-3s5kA:
undetectable		 1j36A-3s5kA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J36_B_LPRB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.83A 1j36B-3s5kA:
undetectable		 1j36B-3s5kA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_A_X8ZA801_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.81A 1j37A-3s5kA:
undetectable		 1j37A-3s5kA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J37_B_X8ZB802_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.81A 1j37B-3s5kA:
undetectable		 1j37B-3s5kA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.85A 1o86A-3s5kA:
undetectable		 1o86A-3s5kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 7 GLU A 548
GLU A 511
ILE A 507
LEU A 822
 None
 1.19A 1q0yH-3s5kA:
1.4
1q0yL-3s5kA:
undetectable		 1q0yH-3s5kA:
9.39
1q0yL-3s5kA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 PHE A1122
SER A1118
VAL A 659
PHE A 691
VAL A 727
 None
 1.16A 1q23H-3s5kA:
undetectable
1q23I-3s5kA:
undetectable		 1q23H-3s5kA:
9.21
1q23I-3s5kA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHS_A_CLMA999_0
(PROTEIN
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE))		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 VAL A 430
ILE A 460
PHE A 458
ILE A 486
LEU A 490
 None
 1.03A 1qhsA-3s5kA:
undetectable		 1qhsA-3s5kA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QVT_A_PRLA311_0
(TRANSCRIPTIONAL
REGULATOR QACR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 LEU A 151
GLU A 152
ILE A 184
TYR A 188
 None
 0.70A 1qvtA-3s5kA:
undetectable		 1qvtA-3s5kA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_C_ADNC1503_1
(CLASS B ACID
PHOSPHATASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 PHE A 640
TYR A 144
GLY A 186
ASP A 190
 None
 0.98A 1rmtC-3s5kA:
undetectable		 1rmtC-3s5kA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 SER A1158
LEU A1155
LEU A1038
PHE A1152
ILE A1055
 None
 1.39A 1uobA-3s5kA:
undetectable		 1uobA-3s5kA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_0
(AMINOMETHYLTRANSFERA
SE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 LEU A 252
ILE A 445
VAL A 444
ASN A 857
LEU A 584
 None
 1.35A 1wsvA-3s5kA:
undetectable		 1wsvA-3s5kA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 TYR A  86
ASP A 540
ILE A  99
PHE A 304
GLN A  97
 None
 1.02A 1xomA-3s5kA:
undetectable		 1xomA-3s5kA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_B_SALB503_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 10 ALA A 173
LEU A 160
PHE A 113
PHE A 115
LEU A 151
 None
 1.47A 1y7iB-3s5kA:
undetectable		 1y7iB-3s5kA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 LEU A 252
ILE A 445
ASP A 356
GLY A 586
TYR A 354
 None
 0.97A 1zz1A-3s5kA:
undetectable		 1zz1A-3s5kA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_C_SHHC2652_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 LEU A 252
ILE A 445
ASP A 356
GLY A 586
TYR A 354
 None
 0.94A 1zz1C-3s5kA:
undetectable		 1zz1C-3s5kA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 LYS A1159
ASP A1058
ASP A 800
 None
 1.15A 2br4A-3s5kA:
undetectable		 2br4A-3s5kA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		6 / 12 ALA A 162
HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 None
ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.79A 2c6nA-3s5kA:
undetectable		 2c6nA-3s5kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.91A 2c6nB-3s5kA:
undetectable		 2c6nB-3s5kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 5 LEU A 422
ALA A 505
ILE A 781
SER A 501
 None
 0.95A 2othA-3s5kA:
undetectable		 2othA-3s5kA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 LEU A 898
LEU A 916
ASN A 894
ILE A 766
ILE A 889
 None
 1.09A 2uxoB-3s5kA:
undetectable		 2uxoB-3s5kA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 10 SER A 506
ILE A 418
PHE A 458
LEU A 370
GLY A 448
 None
 1.16A 2v0mA-3s5kA:
undetectable		 2v0mA-3s5kA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_A_PRLA1188_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 SER A 501
ASN A 499
ILE A 781
ASP A 778
 None
 0.99A 2v57A-3s5kA:
undetectable		 2v57A-3s5kA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V57_C_PRLC1187_0
(TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 SER A 501
ASN A 499
ILE A 781
ASP A 778
 None
 0.97A 2v57C-3s5kA:
undetectable		 2v57C-3s5kA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 7 VAL A1042
GLY A1050
ALA A1066
LEU A1064
 None
 0.92A 2wekB-3s5kA:
undetectable		 2wekB-3s5kA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X8Z_A_X8ZA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.81A 2x8zA-3s5kA:
undetectable		 2x8zA-3s5kA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X91_A_LPRA1615_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.82A 2x91A-3s5kA:
undetectable		 2x91A-3s5kA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 9 GLY A1050
TYR A1049
GLY A1047
HIS A 133
ILE A 239
 None
None
None
ZN  A1194 (-4.0A)
None
 1.39A 2y7wA-3s5kA:
undetectable		 2y7wA-3s5kA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 9 THR A1104
ILE A1101
TYR A1100
PHE A1149
ILE A1029
 None
 1.32A 2y7wA-3s5kA:
undetectable		 2y7wA-3s5kA:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 ILE A  61
ASN A 104
GLY A 102
ASP A 108
TYR A  78
 None
 1.13A 2zw9A-3s5kA:
undetectable		 2zw9A-3s5kA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH504_3
(PHOSPHOLIPASE A2)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 GLY A 126
ILE A 127
PRO A 128
THR A 169
LYS A 300
 None
 1.32A 3bjwH-3s5kA:
undetectable		 3bjwH-3s5kA:
6.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 LYS A 926
LYS A 952
VAL A 955
 None
 1.05A 3brfA-3s5kA:
undetectable		 3brfA-3s5kA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRE_X_TOPX300_1
(DIHYDROFOLATE
REDUCTASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 9 LEU A 431
LEU A 490
VAL A 493
ILE A 419
PHE A 498
 None
 1.22A 3freX-3s5kA:
undetectable		 3freX-3s5kA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IHZ_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE, PUTATIVE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 TYR A 809
GLY A1013
SER A1060
ILE A1014
 None
 0.79A 3ihzB-3s5kA:
undetectable		 3ihzB-3s5kA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 TYR A 627
TYR A 202
PHE A 288
GLU A 207
TYR A 285
 None
 1.32A 3q5pA-3s5kA:
undetectable		 3q5pA-3s5kA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 LEU A 912
ARG A 854
ASN A 894
 None
 0.72A 3qxvD-3s5kA:
undetectable		 3qxvD-3s5kA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R2C_A_ACTA153_0
(N UTILIZATION
SUBSTANCE PROTEIN B)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 4 ASN A 363
GLY A 586
GLU A 585
LYS A 353
 None
 1.34A 3r2cA-3s5kA:
0.3		 3r2cA-3s5kA:
7.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_E_9PLE1_1
(CYTOCHROME P450 2A13)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 PHE A 762
PHE A 924
ASN A 769
ALA A 836
 None
 1.06A 3t3sE-3s5kA:
undetectable		 3t3sE-3s5kA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 7 TYR A  86
ILE A  99
PHE A 304
GLN A  97
 None
 0.94A 3tvxB-3s5kA:
undetectable		 3tvxB-3s5kA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_C_ZPCC1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 VAL A 187
ILE A 184
GLU A 632
ILE A 203
GLU A 207
 None
 1.18A 4a97B-3s5kA:
2.1
4a97C-3s5kA:
2.0		 4a97B-3s5kA:
14.52
4a97C-3s5kA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C2P_A_X8ZA709_1
(ANGIOTENSIN-CONVERTI
NG ENZYME)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.82A 4c2pA-3s5kA:
undetectable		 4c2pA-3s5kA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 7 THR A 169
LEU A 136
VAL A 301
VAL A 117
 None
 0.97A 4cp4A-3s5kA:
undetectable		 4cp4A-3s5kA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 4 GLU A1147
ASP A1148
ARG A1086
THR A1144
 None
 1.37A 4ej1A-3s5kA:
0.0		 4ej1A-3s5kA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_D_ACTD305_0
(GLUTATHIONE
TRANSFERASE GTE1)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 4 ILE A 856
LEU A 852
LYS A 855
ASN A 894
 None
 1.44A 4g19D-3s5kA:
undetectable		 4g19D-3s5kA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 5 LEU A1015
SER A1060
LEU A1022
LEU A1156
 None
 1.18A 4n09B-3s5kA:
undetectable		 4n09B-3s5kA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_2
(ADENOSINE KINASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 5 LEU A1015
SER A1060
LEU A1022
LEU A1156
 None
 1.19A 4n09D-3s5kA:
undetectable		 4n09D-3s5kA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 HIS A 133
GLU A 132
HIS A 129
GLU A 243
TYR A1049
 ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
None
 0.85A 4r7lA-3s5kA:
undetectable		 4r7lA-3s5kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 TYR A 163
HIS A 133
GLU A 132
HIS A 129
GLU A 243
 None
ZN  A1194 (-4.0A)
ZN  A1194 ( 4.4A)
ZN  A1194 (-4.1A)
ZN  A1194 (-2.0A)
 1.39A 4r7lA-3s5kA:
undetectable		 4r7lA-3s5kA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 6 TYR A 413
ARG A 539
GLU A 530
LEU A 453
 None
 1.39A 4twdF-3s5kA:
undetectable
4twdG-3s5kA:
undetectable		 4twdF-3s5kA:
14.43
4twdG-3s5kA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 5 LEU A 370
GLU A 259
LEU A 449
HIS A 572
 None
 1.33A 4xi3B-3s5kA:
undetectable		 4xi3B-3s5kA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 ASP A1040
LEU A 150
GLY A 149
 None
 0.54A 4xmfA-3s5kA:
undetectable		 4xmfA-3s5kA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 LEU A 852
THR A 764
LEU A 765
LEU A 761
 None
 0.78A 4z90F-3s5kA:
undetectable
4z90G-3s5kA:
undetectable
4z90H-3s5kA:
undetectable
4z90I-3s5kA:
undetectable
4z90J-3s5kA:
undetectable		 4z90F-3s5kA:
13.94
4z90G-3s5kA:
13.94
4z90H-3s5kA:
13.94
4z90I-3s5kA:
13.94
4z90J-3s5kA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 LEU A 871
VAL A 875
LEU A1075
SER A1012
SER A1008
 None
 1.33A 4zbqA-3s5kA:
undetectable		 4zbqA-3s5kA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 LEU A 929
PHE A 958
PHE A 746
PHE A 815
ALA A 792
 None
 1.22A 5ieoA-3s5kA:
undetectable		 5ieoA-3s5kA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 ILE A 888
ILE A 851
ILE A 919
LEU A 916
VAL A 848
 None
 0.92A 5mueA-3s5kA:
undetectable		 5mueA-3s5kA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PAH_A_LDPA600_1
(PHENYLALANINE
4-MONOOXYGENASE)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 4 HIS A 129
HIS A 133
TYR A1049
GLU A 243
 ZN  A1194 (-4.1A)
ZN  A1194 (-4.0A)
None
ZN  A1194 (-2.0A)
 1.44A 5pahA-3s5kA:
undetectable		 5pahA-3s5kA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 MET A 260
ALA A 368
SER A 366
LEU A 255
ASP A 446
 None
 1.31A 5vlmF-3s5kA:
undetectable		 5vlmF-3s5kA:
8.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_A_SAMA504_0
(RADICAL SAM DOMAIN
PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 11 TYR A 116
PHE A 291
GLU A 336
THR A 121
VAL A 170
 None
 1.29A 5whyA-3s5kA:
0.0		 5whyA-3s5kA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WHY_B_SAMB504_0
(RADICAL SAM DOMAIN
PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 10 TYR A 116
PHE A 291
GLU A 336
THR A 121
VAL A 170
 None
 1.33A 5whyB-3s5kA:
0.0		 5whyB-3s5kA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 6 LEU A 852
GLN A 901
LEU A 904
LEU A 912
 None
 1.17A 5yvnA-3s5kA:
undetectable		 5yvnA-3s5kA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 5 ILE A 606
PHE A 609
TYR A 211
THR A 281
 None
 1.24A 5z84N-3s5kA:
1.1
5z84W-3s5kA:
undetectable		 5z84N-3s5kA:
17.08
5z84W-3s5kA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 7 PHE A1149
ARG A1086
LEU A1085
ALA A1032
 None
 1.29A 6b89A-3s5kA:
undetectable		 6b89A-3s5kA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 GLU A1094
LEU A1098
ARG A1099
 None
 0.74A 6d8fA-3s5kA:
undetectable		 6d8fA-3s5kA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		3 / 3 HIS A 133
ARG A1043
ILE A 239
 ZN  A1194 (-4.0A)
None
None
 0.73A 6fgdA-3s5kA:
undetectable		 6fgdA-3s5kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		5 / 12 VAL A 955
THR A 673
ASN A 687
VAL A 727
ASN A 726
 None
 1.40A 6h7lB-3s5kA:
undetectable		 6h7lB-3s5kA:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MDQ_A_TESA604_0
(SERUM ALBUMIN)		 3s5k FALCILYSIN
(Plasmodium
falciparum) 		4 / 8 ALA A1089
GLY A1084
LEU A1085
ALA A1153
 None
 0.73A 6mdqA-3s5kA:
undetectable		 6mdqA-3s5kA:
5.63