SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 242
ILE A 291
ASP A 320
PRO A 275
 None
 1.22A 1ditH-3s5nA:
undetectable
1ditP-3s5nA:
undetectable		 1ditH-3s5nA:
20.13
1ditP-3s5nA:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y7I_A_SALA502_1
(SALICYLIC
ACID-BINDING PROTEIN
2)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 LEU A 207
HIS A 210
LYS A 211
 None
 1.13A 1y7iA-3s5nA:
undetectable		 1y7iA-3s5nA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ALA A 243
GLY A 225
VAL A 279
PRO A  40
PHE A  69
 None
 1.15A 2okcB-3s5nA:
undetectable		 2okcB-3s5nA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_A_DIFA1373_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 SER A 198
PHE A 226
TYR A 168
ASN A 276
 None
 1.18A 2wekA-3s5nA:
2.8		 2wekA-3s5nA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 7 VAL A 239
TYR A  39
GLY A 109
VAL A 166
 None
 0.84A 2y05A-3s5nA:
undetectable
2y05B-3s5nA:
2.6		 2y05A-3s5nA:
22.48
2y05B-3s5nA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A 191
VAL A 135
ALA A 133
THR A 115
THR A 118
 None
 1.01A 3czhA-3s5nA:
undetectable		 3czhA-3s5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ASN A 191
VAL A 135
ALA A 133
THR A 115
THR A 118
 None
 1.03A 3dl9B-3s5nA:
undetectable		 3dl9B-3s5nA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_B_EAAB222_1
(GLUTATHIONE
S-TRANSFERASE P)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 TYR A 154
VAL A 135
VAL A 119
GLN A 116
GLY A 111
 None
 1.48A 3km6B-3s5nA:
undetectable		 3km6B-3s5nA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OWX_B_XRAB233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 VAL A  42
PHE A  69
GLY A 238
GLY A 237
TYR A 231
 EDO  A   3 (-3.7A)
None
None
None
None
 1.48A 3owxA-3s5nA:
undetectable
3owxB-3s5nA:
undetectable		 3owxA-3s5nA:
23.25
3owxB-3s5nA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_A_UEGA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 11 GLY A  37
ALA A 221
GLY A 238
VAL A 250
CYH A 240
 None
 1.07A 4c5lA-3s5nA:
3.3		 4c5lA-3s5nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5L_D_UEGD300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 10 GLY A  37
ALA A 221
GLY A 238
VAL A 250
CYH A 240
 None
 1.07A 4c5lD-3s5nA:
3.1		 4c5lD-3s5nA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 ILE A 205
PHE A 226
GLY A 225
ALA A 224
SER A 223
 None
 1.07A 4e1gB-3s5nA:
undetectable		 4e1gB-3s5nA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 8 LEU A 160
VAL A 119
VAL A 123
GLN A 127
 None
 0.87A 4em2A-3s5nA:
undetectable		 4em2A-3s5nA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 ILE A 151
THR A 155
VAL A 180
ASP A 197
 None
 0.89A 4iaqA-3s5nA:
undetectable		 4iaqA-3s5nA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 300
ASP A  53
ILE A 291
GLY A 287
ASN A 244
 None
None
None
None
EDO  A   3 (-3.5A)
 1.06A 4obwB-3s5nA:
undetectable		 4obwB-3s5nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 GLY A 300
ASP A  53
ILE A 291
GLY A 287
ASN A 244
 None
None
None
None
EDO  A   3 (-3.5A)
 1.30A 4obwC-3s5nA:
undetectable		 4obwC-3s5nA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 12 LEU A 220
LEU A 107
MET A 134
ILE A 205
PHE A 226
 None
 1.41A 4p6xI-3s5nA:
undetectable		 4p6xI-3s5nA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QD3_A_5AEA201_1
(PEPTIDYL-TRNA
HYDROLASE)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		5 / 9 LEU A  57
GLY A  79
VAL A  92
VAL A  96
LEU A 106
 EDO  A   3 ( 4.9A)
None
None
None
None
 1.19A 4qd3A-3s5nA:
undetectable		 4qd3A-3s5nA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		3 / 3 GLY A 222
VAL A 166
MET A 134
 None
 0.65A 5ycpA-3s5nA:
undetectable		 5ycpA-3s5nA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_G_TA1G501_2
(TUBULIN BETA CHAIN)		 3s5n 4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE,
MITOCHONDRIAL
(Homo
sapiens) 		4 / 6 LEU A 288
LEU A  64
THR A  44
ARG A  97
 None
 1.08A 6ew0G-3s5nA:
undetectable		 6ew0G-3s5nA:
14.14