SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 12 ASN A 133
MET A  86
LEU A  90
ARG A  93
LEU A 157
 None
 1.30A 1nhzA-3s5rA:
undetectable		 1nhzA-3s5rA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_1
(THYROXINE-BINDING
GLOBULIN)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 11 SER A 136
LEU A 197
SER A 154
LEU A 157
LEU A 164
 None
 0.85A 2xn5A-3s5rA:
undetectable		 2xn5A-3s5rA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		3 / 3 GLU A  24
SER A  38
VAL A  39
 None
 0.65A 3eeoA-3s5rA:
undetectable		 3eeoA-3s5rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 12 CYH A  98
THR A 100
ILE A  72
ILE A  94
MET A  71
 None
 1.16A 3gwxA-3s5rA:
undetectable		 3gwxA-3s5rA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 12 ILE A  65
ILE A 162
ILE A 158
ASP A  70
LEU A  90
 None
PEG  A 302 (-4.6A)
None
None
None
 0.97A 3uj6A-3s5rA:
undetectable		 3uj6A-3s5rA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 10 ILE A  94
THR A 165
GLY A 163
GLY A 159
PHE A 135
 None
 1.13A 4bwlC-3s5rA:
undetectable		 4bwlC-3s5rA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3s5r TRANSCRIPTIONAL
REGULATOR TETR
FAMILY
(Syntrophus
aciditrophicus) 		5 / 10 PRO A 128
ILE A  72
ILE A 158
ILE A 162
ILE A 161
 None
None
None
PEG  A 302 (-4.6A)
None
 1.05A 5murE-3s5rA:
2.6		 5murE-3s5rA:
15.28