SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 PHE A 312
LEU A 316
ALA A 284
ALA A 280
LEU A 112
 None
 0.97A 1cbsA-3s5sA:
undetectable		 1cbsA-3s5sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GEB_A_CAMA418_0
(CYTOCHROME P450-CAM)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 9 LEU A 199
VAL A 167
ILE A 179
VAL A 218
ILE A 192
 None
 1.39A 1gebA-3s5sA:
undetectable		 1gebA-3s5sA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 PHE A  58
LEU A 220
VAL A 244
ALA A 250
ALA A 246
 None
 1.30A 1q23A-3s5sA:
undetectable
1q23B-3s5sA:
undetectable		 1q23A-3s5sA:
18.50
1q23B-3s5sA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_D_SAMD301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 LEU A  92
GLY A 101
SER A  96
ALA A 102
ALA A  53
 None
 1.11A 2br4D-3s5sA:
undetectable		 2br4D-3s5sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 ALA A  57
ASP A 247
ASN A  59
GLY A  28
ILE A  25
 None
 1.31A 2dcfA-3s5sA:
undetectable		 2dcfA-3s5sA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FR3_A_REAA300_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
2)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 PHE A 312
LEU A 316
ALA A 284
ALA A 280
LEU A 112
 None
 0.98A 2fr3A-3s5sA:
undetectable		 2fr3A-3s5sA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_C_SNLC3001_1
(MINERALOCORTICOID
RECEPTOR)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 ALA A  53
MET A 306
LEU A 272
LEU A 324
PHE A  23
 None
 1.46A 2oaxC-3s5sA:
undetectable		 2oaxC-3s5sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_1
(MINERALOCORTICOID
RECEPTOR)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 MET A 306
LEU A 272
LEU A 324
THR A 139
PHE A  23
 None
 1.40A 2oaxF-3s5sA:
undetectable		 2oaxF-3s5sA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 8 MET A 299
ARG A 227
SER A 309
GLY A 275
 None
 1.07A 2qd5B-3s5sA:
3.5		 2qd5B-3s5sA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 11 ALA A  57
ASP A 247
ASN A  59
GLY A  28
ILE A  25
 None
 1.29A 2zmaA-3s5sA:
undetectable		 2zmaA-3s5sA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		3 / 3 ARG A 118
LEU A  42
THR A   2
 None
 0.84A 3oxcA-3s5sA:
undetectable		 3oxcA-3s5sA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 ALA A  57
ASP A 247
ASN A  59
GLY A  28
ILE A  25
 None
 1.28A 3vwqA-3s5sA:
undetectable		 3vwqA-3s5sA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 GLU A  61
LEU A  36
VAL A  38
ILE A  12
LEU A 371
 None
 1.29A 4k39A-3s5sA:
3.9		 4k39A-3s5sA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 6 GLU A 254
ARG A 258
ASP A 255
ARG A 227
 None
 1.06A 4kcnA-3s5sA:
undetectable		 4kcnA-3s5sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 6 GLU A 254
ARG A 258
ASP A 255
ARG A 227
 None
 1.11A 4kcnB-3s5sA:
undetectable		 4kcnB-3s5sA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOT_A_CE3A205_1
(UNCHARACTERIZED
PROTEIN)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 PRO A 327
GLY A 298
ILE A 296
PHE A 339
LEU A 346
 None
 1.01A 4kotA-3s5sA:
undetectable		 4kotA-3s5sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOV_A_KOVA204_1
(UNCHARACTERIZED
PROTEIN)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 PRO A 327
GLY A 298
ILE A 296
PHE A 339
LEU A 346
 None
 1.03A 4kovA-3s5sA:
undetectable		 4kovA-3s5sA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 GLY A 131
ALA A 314
GLY A 129
GLY A 315
LEU A 123
 None
 0.89A 4o33A-3s5sA:
2.3		 4o33A-3s5sA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O3F_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 GLY A 131
ALA A 314
GLY A 129
GLY A 315
LEU A 123
 None
 0.82A 4o3fA-3s5sA:
undetectable		 4o3fA-3s5sA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 ASN A 269
VAL A 268
ALA A 265
LEU A 221
GLY A 195
 None
 1.21A 4qckA-3s5sA:
undetectable		 4qckA-3s5sA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 5 LEU A  92
ALA A  69
VAL A  38
ILE A  12
 None
 0.79A 4xe3A-3s5sA:
undetectable		 4xe3A-3s5sA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_B_CL6B502_1
(CYTOCHROME P-450)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 5 LEU A  92
ALA A  69
VAL A  38
ILE A  12
 None
 0.81A 4xe3B-3s5sA:
undetectable		 4xe3B-3s5sA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		5 / 12 VAL A 236
GLU A 235
ASP A 194
ALA A 204
ARG A 227
 None
 1.41A 5hnzB-3s5sA:
3.1		 5hnzB-3s5sA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_A_C2FA3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		3 / 3 ASP A 247
ASN A 269
ASP A 323
 None
 0.82A 5vopA-3s5sA:
10.1		 5vopA-3s5sA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOP_B_C2FB3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		3 / 3 ASP A 247
ASN A 269
ASP A 323
 None
 0.77A 5vopB-3s5sA:
5.1		 5vopB-3s5sA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_E_PCFE202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3s5s MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN
(Sorangium
cellulosum) 		4 / 8 ALA A  87
VAL A  88
ARG A  86
ASP A 282
 None
None
SO4  A 390 (-3.9A)
None
 1.01A 6hu9a-3s5sA:
undetectable
6hu9e-3s5sA:
undetectable		 6hu9a-3s5sA:
22.70
6hu9e-3s5sA:
15.94