SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 10 LEU A 186
ALA A 230
ASP A 228
ILE A 251
PHE A 235
 None
 1.18A 1d4sA-3s5tA:
undetectable		 1d4sA-3s5tA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 8 TYR A 265
MET A 268
PHE A 190
LEU A 237
 None
 1.07A 1ea1A-3s5tA:
undetectable		 1ea1A-3s5tA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_A_SAMA500_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 12 ASN A 204
PRO A 253
GLY A 224
SER A 225
THR A 226
 None
 1.37A 1g60A-3s5tA:
undetectable		 1g60A-3s5tA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 209
LEU A 202
LEU A 206
 None
 0.44A 1ikeA-3s5tA:
undetectable		 1ikeA-3s5tA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 ASP A 209
LEU A 202
LEU A 206
 None
 0.50A 1np1B-3s5tA:
undetectable		 1np1B-3s5tA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 TYR A 105
TYR A 137
TYR A 101
ILE A  59
 MPD  A 287 ( 4.5A)
None
None
None
 1.25A 2pgzD-3s5tA:
undetectable
2pgzE-3s5tA:
undetectable		 2pgzD-3s5tA:
19.93
2pgzE-3s5tA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 8 ILE A 242
LEU A 151
ILE A 189
PHE A 235
 None
 0.70A 2w9sE-3s5tA:
undetectable		 2w9sE-3s5tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 LYS A  52
PRO A  53
LEU A  46
 None
 0.87A 3tpxE-3s5tA:
undetectable		 3tpxE-3s5tA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 TYR A 169
GLY A 257
PRO A 258
 None
 0.69A 4qwpA-3s5tA:
undetectable		 4qwpA-3s5tA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 12 SER A  67
PHE A  80
LEU A 152
LEU A 178
TYR A 147
 None
 1.29A 4xumA-3s5tA:
undetectable		 4xumA-3s5tA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_J_Z80J401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		5 / 12 ILE A 189
PHE A 235
GLU A 280
ASN A 150
ASP A 177
 None
 1.21A 5lg3J-3s5tA:
undetectable		 5lg3J-3s5tA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		3 / 3 THR A 232
THR A 252
LEU A 206
 None
 0.70A 5m66D-3s5tA:
undetectable		 5m66D-3s5tA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_A_486A801_2
(GLUCOCORTICOID
RECEPTOR)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 5 LEU A 152
LEU A 178
MET A 281
TYR A 236
 None
 1.28A 5uc3A-3s5tA:
undetectable		 5uc3A-3s5tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 3s5t DUF3298 FAMILY
PROTEIN
(Bacteroides
fragilis) 		4 / 6 ASN A 275
ASN A 150
PRO A 276
ILE A 277
 None
 1.22A 6h7uA-3s5tA:
undetectable		 6h7uA-3s5tA:
18.72