SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s5w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 4 VAL A 147
LEU A  25
ILE A 419
LEU A 423
 None
 0.76A 2byoA-3s5wA:
undetectable		 2byoA-3s5wA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 GLY A 185
ASP A 184
ALA A 324
THR A 323
ALA A 322
 None
 1.04A 2gluA-3s5wA:
3.4		 2gluA-3s5wA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 159
ILE A  23
PHE A 120
ALA A 117
GLU A 128
 PO4  A 444 (-4.0A)
None
None
None
None
 1.19A 2j0dA-3s5wA:
undetectable		 2j0dA-3s5wA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 ILE A 419
LEU A 412
LEU A  71
PHE A  43
 None
 0.85A 2vctB-3s5wA:
undetectable		 2vctB-3s5wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 SER A 149
TYR A 126
SER A 167
GLN A 395
 None
 1.41A 2zvjA-3s5wA:
3.2		 2zvjA-3s5wA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FAL_C_REAC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 0.86A 3falC-3s5wA:
undetectable		 3falC-3s5wA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FC6_A_REAA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 0.94A 3fc6A-3s5wA:
undetectable		 3fc6A-3s5wA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 0.96A 3oapA-3s5wA:
undetectable		 3oapA-3s5wA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.85A 3u9hA-3s5wA:
undetectable		 3u9hA-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.85A 3u9hB-3s5wA:
undetectable		 3u9hB-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 SER A 191
TYR A 193
ILE A 210
ALA A 235
VAL A 288
 None
 1.20A 3vw1D-3s5wA:
undetectable		 3vw1D-3s5wA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.83A 4bjcA-3s5wA:
undetectable		 4bjcA-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 10 LEU A  25
ILE A  23
GLY A  15
GLY A  17
PHE A 120
 None
None
None
FAD  A 450 (-3.4A)
None
 1.00A 4fakA-3s5wA:
undetectable		 4fakA-3s5wA:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_2
(DIPEPTIDYL PEPTIDASE
4)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		3 / 3 PHE A 188
TYR A 230
TYR A 193
 None
 1.07A 4ffwA-3s5wA:
undetectable		 4ffwA-3s5wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU8_A_ACTA302_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 5 HIS A 402
GLN A 395
GLY A 396
SER A 398
 None
 0.96A 4fu8A-3s5wA:
undetectable		 4fu8A-3s5wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 7 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.89A 4hyfA-3s5wA:
undetectable		 4hyfA-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_B_NCAB1201_0
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.88A 4hyfB-3s5wA:
undetectable		 4hyfB-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_C_NCAC1201_0
(TANKYRASE-2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 8 GLY A 421
ALA A  28
SER A 420
TYR A 424
 None
 0.87A 4hyfC-3s5wA:
undetectable		 4hyfC-3s5wA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8F_B_MTXB301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 11 GLY A 214
GLY A 215
ALA A 352
HIS A 190
GLN A 217
 NAP  A 452 ( 3.8A)
NAP  A 452 (-3.4A)
None
None
None
 1.00A 4l8fB-3s5wA:
undetectable		 4l8fB-3s5wA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O79_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 206
TYR A 230
ALA A 198
MET A 197
 None
 1.21A 4o79B-3s5wA:
0.0		 4o79B-3s5wA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		4 / 6 LYS A 206
TYR A 230
ALA A 198
MET A 197
 None
 1.28A 4o7gB-3s5wA:
undetectable		 4o7gB-3s5wA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  44
LEU A 367
LEU A 364
THR A 161
ALA A 163
 None
 1.20A 5ieoA-3s5wA:
undetectable		 5ieoA-3s5wA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  44
LEU A 367
LEU A 364
THR A 161
ALA A 163
 None
 1.20A 5iepA-3s5wA:
undetectable		 5iepA-3s5wA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 184
GLY A 185
PHE A 188
ILE A 329
ALA A 324
 None
 1.04A 5j7wD-3s5wA:
undetectable		 5j7wD-3s5wA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 1.00A 6a5yD-3s5wA:
undetectable		 6a5yD-3s5wA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Z_L_9CRL501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3s5w L-ORNITHINE
5-MONOOXYGENASE
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 419
ALA A 416
LEU A  25
ALA A  24
ILE A 376
 None
 0.95A 6a5zL-3s5wA:
undetectable		 6a5zL-3s5wA:
10.25