SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s69'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1AQ7_B_AG2B4_1 (TRYPSIN AERUGINOSIN 98-B)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 8	HIS A 56 ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.59A	1aq7A-3s69A: 34.4	1aq7A-3s69A: 44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1BCU_H_PRLH280_0 (ALPHA-THROMBIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 9	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.32A	1bcuH-3s69A: 16.4	1bcuH-3s69A: 31.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DBB_H_STRH229_1 (IGG1-KAPPA DB3 FAB (HEAVY CHAIN) IGG1-KAPPA DB3 FAB (LIGHT CHAIN))	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 8	GLY A 193 GLY A 139 TYR A 148 VAL A 68	None	0.93A	1dbbH-3s69A: undetectable 1dbbL-3s69A: undetectable	1dbbH-3s69A: 20.63 1dbbL-3s69A: 22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_A_FFOA1293_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	3 / 3	GLU A 171 TYR A 169 PHE A 211	None	0.86A	1eqbB-3s69A: undetectable	1eqbB-3s69A: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_B_FFOB2293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	3 / 3	GLU A 171 TYR A 169 PHE A 211	None	0.87A	1eqbA-3s69A: undetectable	1eqbA-3s69A: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_C_FFOC3293_2 (SERINE HYDROXYMETHYLTRANSFE RASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	3 / 3	GLU A 171 TYR A 169 PHE A 211	None	0.86A	1eqbD-3s69A: undetectable	1eqbD-3s69A: 18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1EQB_D_FFOD4293_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	3 / 3	GLU A 171 TYR A 169 PHE A 211	None	0.88A	1eqbC-3s69A: undetectable	1eqbC-3s69A: 18.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1ETR_H_MITH1_1 (EPSILON-THROMBIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	HIS A 56 ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.53A	1etrH-3s69A: 31.3	1etrH-3s69A: 32.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1F5L_A_AMRA301_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 8	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.51A	1f5lA-3s69A: 10.5	1f5lA-3s69A: 29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OIP_A_VIVA1278_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 12	ILE A 208 ILE A 117 ILE A 105 LEU A 107 VAL A 111	None	1.00A	1oipA-3s69A: undetectable	1oipA-3s69A: 21.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1TNL_A_TPAA900_1 (TRYPSIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 6	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.50A	1tnlA-3s69A: 35.0	1tnlA-3s69A: 43.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2D55_C_DVAC2_0 (ACTINOMYCIN D)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	3 / 3	THR A 246 PRO A 248 PRO A 90	None	0.82A	2d55C-3s69A: undetectable	2d55C-3s69A: 4.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2OTV_A_NCAA1301_0 (CATIONIC TRYPSIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 6	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.43A	2otvA-3s69A: 35.2	2otvA-3s69A: 44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_A_SAMA300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 LEU A 52	None	1.43A	2oxtA-3s69A: undetectable	2oxtA-3s69A: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_D_SAMD300_0 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 LEU A 52	None	1.44A	2oxtD-3s69A: undetectable	2oxtD-3s69A: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2P16_A_GG2A298_1 (COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR))	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223 TYR A 225	None	0.47A	2p16A-3s69A: 11.9	2p16A-3s69A: 29.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PXC_A_SAMA500_0 (GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN) ENVELOPE PROTEIN M (MATRIX PROTEIN) MAJOR ENVELOPE PROTEIN E NON-STRUCTURAL PROTEIN 1 (NS1) NON-STRUCTURAL PROTEIN 2A (NS2A) FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT NON-STRUCTURAL PROTEIN 4A (NS4A) NON-STRUCTURAL PROTEIN 4B (NS4B) RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48) (NS5)])	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.35A	2pxcA-3s69A: undetectable	2pxcA-3s69A: 20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VIN_A_505A1247_1 (UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 8	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.60A	2vinA-3s69A: 9.3	2vinA-3s69A: 29.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W26_A_RIVA1001_1 (ACTIVATED FACTOR XA HEAVY CHAIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	ASP A 189 SER A 195 VAL A 209 GLY A 212 GLY A 223 TYR A 225	None	0.32A	2w26A-3s69A: 11.0	2w26A-3s69A: 29.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3GY3_A_PNTA246_0 (CATIONIC TRYPSIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 11	HIS A 56 ASP A 189 SER A 195 GLY A 212 GLY A 223	None	0.52A	3gy3A-3s69A: 33.8	3gy3A-3s69A: 44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P97_C_SAMC263_0 (NON-STRUCTURAL PROTEIN 5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.28A	3p97C-3s69A: undetectable	3p97C-3s69A: 20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RXF_A_4APA9_1 (CATIONIC TRYPSIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 6	SER A 195 VAL A 209 GLY A 212 GLY A 223	None	0.38A	3rxfA-3s69A: 14.7	3rxfA-3s69A: 44.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3RXH_A_HSMA7_1 (CATIONIC TRYPSIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 5	ASP A 189 SER A 195 VAL A 209 GLY A 223	None	0.36A	3rxhA-3s69A: 34.9	3rxhA-3s69A: 44.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S43_A_478A401_1 (PROTEASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	5 / 9	ALA A 181 ILE A 135 VAL A 209 GLY A 212 ILE A 157	None	0.95A	3s43A-3s69A: undetectable	3s43A-3s69A: 17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TNE_B_RITB401_2 (SECRETED ASPARTIC PROTEASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 7	SER A 195 THR A 226 THR A 178 TYR A 231	None	0.90A	3tneB-3s69A: undetectable	3tneB-3s69A: 19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_B_W9TB513_1 (HEMOLYTIC LECTIN CEL-III)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 6	THR A 60 ASN A 59 ASP A 58 ILE A 88	None	1.10A	3w9tB-3s69A: undetectable	3w9tB-3s69A: 20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTJ_A_SAMA1263_0 (NON-STRUCTURAL PROTEIN 5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.28A	4ctjA-3s69A: undetectable	4ctjA-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTJ_C_SAMC1263_0 (NON-STRUCTURAL PROTEIN 5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	4ctjC-3s69A: undetectable	4ctjC-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTK_A_SAMA1263_0 (POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.30A	4ctkA-3s69A: undetectable	4ctkA-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4CTK_C_SAMC1263_0 (POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	4ctkC-3s69A: undetectable	4ctkC-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_C_CLQC303_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 8	GLY A 43 VAL A 31 PHE A 205 ILE A 46	None	0.74A	4fglD-3s69A: undetectable	4fglD-3s69A: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4FGL_D_CLQD303_0 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 7	GLY A 43 VAL A 31 PHE A 205 ILE A 46	None	0.69A	4fglC-3s69A: undetectable	4fglC-3s69A: 21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E9Q_A_SAMA301_0 (GENOME POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.29A	5e9qA-3s69A: undetectable	5e9qA-3s69A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5E9Q_C_SAMC4000_0 (GENOME POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.29A	5e9qC-3s69A: undetectable	5e9qC-3s69A: 20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EC8_C_SAMC4000_0 (GENOME POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	5ec8C-3s69A: undetectable	5ec8C-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EHG_A_SAMA301_0 (RNA-DIRECTED RNA POLYMERASE NS5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.29A	5ehgA-3s69A: undetectable	5ehgA-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EHG_C_SAMC4001_0 (RNA-DIRECTED RNA POLYMERASE NS5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.28A	5ehgC-3s69A: undetectable	5ehgC-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_A_SAMA301_0 (GENOME POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.28A	5eifA-3s69A: undetectable	5eifA-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIF_C_SAMC4000_0 (GENOME POLYPROTEIN)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	5eifC-3s69A: undetectable	5eifC-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EIW_C_SAMC4000_0 (NS5 METHYLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.26A	5eiwC-3s69A: undetectable	5eiwC-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EKX_B_SAMB4000_0 (NS5 METHYLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	5ekxB-3s69A: undetectable	5ekxB-3s69A: 20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KB5_A_ADNA401_2 (ADENOSINE KINASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 4	ASN A 158 LEU A 160 SER A 131 LEU A 179	None	1.26A	5kb5A-3s69A: undetectable	5kb5A-3s69A: 19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KQR_A_SAMA301_0 (METHYLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.31A	5kqrA-3s69A: undetectable	5kqrA-3s69A: 22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5M5B_A_SAMA1001_0 (NS5 METHYLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.27A	5m5bA-3s69A: undetectable	5m5bA-3s69A: 21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5MZR_E_PFLE409_1 (PROTON-GATED ION CHANNEL)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	4 / 8	PRO A 149 TYR A 153 TYR A 148 THR A 147	None	0.90A	5mzrE-3s69A: undetectable	5mzrE-3s69A: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_A_SAMA301_0 (NS5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.29A	5njvA-3s69A: undetectable	5njvA-3s69A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NJV_B_SAMB301_0 (NS5)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.30A	5njvB-3s69A: undetectable	5njvB-3s69A: 20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_B_SAMB601_0 (NS5 METHYLTRANSFERASE)	3s69	THROMBIN-LIKE ENZYME DEFIBRASE (Gloydius saxatilis)	6 / 12	GLY A 139 GLY A 43 GLY A 196 GLY A 193 THR A 53 VAL A 51	None	1.33A	5wz1B-3s69A: undetectable	5wz1B-3s69A: 20.69

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1AQ7_B_AG2B4_1","TRYPSIN;AERUGINOSIN 98-B","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"HIS A  56;ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.59A","1aq7A-3s69A:34.4","1aq7A-3s69A:44.05"],["1BCU_H_PRLH280_0","ALPHA-THROMBIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.32A","1bcuH-3s69A:16.4","1bcuH-3s69A:31.44"],["1DBB_H_STRH229_1","IGG1-KAPPA DB3 FAB (HEAVY CHAIN);IGG1-KAPPA DB3 FAB (LIGHT CHAIN)","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"GLY A 193;GLY A 139;TYR A 148;VAL A  68","None","0.93A","1dbbH-3s69A:undetectable;1dbbL-3s69A:undetectable","1dbbH-3s69A:20.63;1dbbL-3s69A:22.36"],["1EQB_A_FFOA1293_1","SERINE HYDROXYMETHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",3,"GLU A 171;TYR A 169;PHE A 211","None","0.86A","1eqbB-3s69A:undetectable","1eqbB-3s69A:18.71"],["1EQB_B_FFOB2293_0","SERINE HYDROXYMETHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",3,"GLU A 171;TYR A 169;PHE A 211","None","0.87A","1eqbA-3s69A:undetectable","1eqbA-3s69A:18.71"],["1EQB_C_FFOC3293_2","SERINE HYDROXYMETHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",3,"GLU A 171;TYR A 169;PHE A 211","None","0.86A","1eqbD-3s69A:undetectable","1eqbD-3s69A:18.71"],["1EQB_D_FFOD4293_0","SERINE HYDROXYMETHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",3,"GLU A 171;TYR A 169;PHE A 211","None","0.88A","1eqbC-3s69A:undetectable","1eqbC-3s69A:18.71"],["1ETR_H_MITH1_1","EPSILON-THROMBIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"HIS A  56;ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.53A","1etrH-3s69A:31.3","1etrH-3s69A:32.20"],["1F5L_A_AMRA301_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.51A","1f5lA-3s69A:10.5","1f5lA-3s69A:29.96"],["1OIP_A_VIVA1278_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ILE A 208;ILE A 117;ILE A 105;LEU A 107;VAL A 111","None","1.00A","1oipA-3s69A:undetectable","1oipA-3s69A:21.05"],["1TNL_A_TPAA900_1","TRYPSIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.50A","1tnlA-3s69A:35.0","1tnlA-3s69A:43.78"],["2D55_C_DVAC2_0","ACTINOMYCIN D","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",3,"THR A 246;PRO A 248;PRO A  90","None","0.82A","2d55C-3s69A:undetectable","2d55C-3s69A:4.79"],["2OTV_A_NCAA1301_0","CATIONIC TRYPSIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.43A","2otvA-3s69A:35.2","2otvA-3s69A:44.05"],["2OXT_A_SAMA300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;LEU A  52","None","1.43A","2oxtA-3s69A:undetectable","2oxtA-3s69A:20.95"],["2OXT_D_SAMD300_0","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;LEU A  52","None","1.44A","2oxtD-3s69A:undetectable","2oxtD-3s69A:20.95"],["2P16_A_GG2A298_1","COAGULATION FACTOR X (EC 3.4.21.6) (STUART FACTOR) (STUART-PROWER FACTOR)","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223;TYR A 225","None","0.47A","2p16A-3s69A:11.9","2p16A-3s69A:29.03"],["2PXC_A_SAMA500_0","GENOME POLYPROTEIN [CONTAINS: CAPSID PROTEIN C (CORE PROTEIN); ENVELOPE PROTEIN M (MATRIX PROTEIN); MAJOR ENVELOPE PROTEIN E; NON-STRUCTURAL PROTEIN 1 (NS1); NON-STRUCTURAL PROTEIN 2A (NS2A); FLAVIVIRIN PROTEASE NS2B REGULATORY SUBUNIT; FLAVIVIRIN PROTEASE NS3 CATALYTIC SUBUNIT; NON-STRUCTURAL PROTEIN 4A (NS4A); NON-STRUCTURAL PROTEIN 4B (NS4B); RNA-DIRECTED RNA POLYMERASE (EC 2.7.7.48) (NS5)]","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.35A","2pxcA-3s69A:undetectable","2pxcA-3s69A:20.85"],["2VIN_A_505A1247_1","UROKINASE-TYPE PLASMINOGEN ACTIVATOR CHAIN B","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.60A","2vinA-3s69A:9.3","2vinA-3s69A:29.96"],["2W26_A_RIVA1001_1","ACTIVATED FACTOR XA HEAVY CHAIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"ASP A 189;SER A 195;VAL A 209;GLY A 212;GLY A 223;TYR A 225","None","0.32A","2w26A-3s69A:11.0","2w26A-3s69A:29.03"],["3GY3_A_PNTA246_0","CATIONIC TRYPSIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"HIS A  56;ASP A 189;SER A 195;GLY A 212;GLY A 223","None","0.52A","3gy3A-3s69A:33.8","3gy3A-3s69A:44.05"],["3P97_C_SAMC263_0","NON-STRUCTURAL PROTEIN 5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.28A","3p97C-3s69A:undetectable","3p97C-3s69A:20.15"],["3RXF_A_4APA9_1","CATIONIC TRYPSIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"SER A 195;VAL A 209;GLY A 212;GLY A 223","None","0.38A","3rxfA-3s69A:14.7","3rxfA-3s69A:44.05"],["3RXH_A_HSMA7_1","CATIONIC TRYPSIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"ASP A 189;SER A 195;VAL A 209;GLY A 223","None","0.36A","3rxhA-3s69A:34.9","3rxhA-3s69A:44.05"],["3S43_A_478A401_1","PROTEASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",5,"ALA A 181;ILE A 135;VAL A 209;GLY A 212;ILE A 157","None","0.95A","3s43A-3s69A:undetectable","3s43A-3s69A:17.52"],["3TNE_B_RITB401_2","SECRETED ASPARTIC PROTEASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"SER A 195;THR A 226;THR A 178;TYR A 231","None","0.90A","3tneB-3s69A:undetectable","3tneB-3s69A:19.83"],["3W9T_B_W9TB513_1","HEMOLYTIC LECTIN CEL-III","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"THR A  60;ASN A  59;ASP A  58;ILE A  88","None","1.10A","3w9tB-3s69A:undetectable","3w9tB-3s69A:20.24"],["4CTJ_A_SAMA1263_0","NON-STRUCTURAL PROTEIN 5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.28A","4ctjA-3s69A:undetectable","4ctjA-3s69A:20.00"],["4CTJ_C_SAMC1263_0","NON-STRUCTURAL PROTEIN 5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","4ctjC-3s69A:undetectable","4ctjC-3s69A:20.00"],["4CTK_A_SAMA1263_0","POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.30A","4ctkA-3s69A:undetectable","4ctkA-3s69A:20.00"],["4CTK_C_SAMC1263_0","POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","4ctkC-3s69A:undetectable","4ctkC-3s69A:20.00"],["4FGL_C_CLQC303_1","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"GLY A  43;VAL A  31;PHE A 205;ILE A  46","None","0.74A","4fglD-3s69A:undetectable","4fglD-3s69A:21.76"],["4FGL_D_CLQD303_0","RIBOSYLDIHYDRONICOTINAMIDE DEHYDROGENASE [QUINONE]","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"GLY A  43;VAL A  31;PHE A 205;ILE A  46","None","0.69A","4fglC-3s69A:undetectable","4fglC-3s69A:21.76"],["5E9Q_A_SAMA301_0","GENOME POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.29A","5e9qA-3s69A:undetectable","5e9qA-3s69A:20.90"],["5E9Q_C_SAMC4000_0","GENOME POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.29A","5e9qC-3s69A:undetectable","5e9qC-3s69A:20.90"],["5EC8_C_SAMC4000_0","GENOME POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","5ec8C-3s69A:undetectable","5ec8C-3s69A:20.00"],["5EHG_A_SAMA301_0","RNA-DIRECTED RNA POLYMERASE NS5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.29A","5ehgA-3s69A:undetectable","5ehgA-3s69A:20.00"],["5EHG_C_SAMC4001_0","RNA-DIRECTED RNA POLYMERASE NS5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.28A","5ehgC-3s69A:undetectable","5ehgC-3s69A:20.00"],["5EIF_A_SAMA301_0","GENOME POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.28A","5eifA-3s69A:undetectable","5eifA-3s69A:20.00"],["5EIF_C_SAMC4000_0","GENOME POLYPROTEIN","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","5eifC-3s69A:undetectable","5eifC-3s69A:20.00"],["5EIW_C_SAMC4000_0","NS5 METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.26A","5eiwC-3s69A:undetectable","5eiwC-3s69A:20.00"],["5EKX_B_SAMB4000_0","NS5 METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","5ekxB-3s69A:undetectable","5ekxB-3s69A:20.00"],["5KB5_A_ADNA401_2","ADENOSINE KINASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"ASN A 158;LEU A 160;SER A 131;LEU A 179","None","1.26A","5kb5A-3s69A:undetectable","5kb5A-3s69A:19.73"],["5KQR_A_SAMA301_0","METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.31A","5kqrA-3s69A:undetectable","5kqrA-3s69A:22.30"],["5M5B_A_SAMA1001_0","NS5 METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.27A","5m5bA-3s69A:undetectable","5m5bA-3s69A:21.65"],["5MZR_E_PFLE409_1","PROTON-GATED ION CHANNEL","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",4,"PRO A 149;TYR A 153;TYR A 148;THR A 147","None","0.90A","5mzrE-3s69A:undetectable","5mzrE-3s69A:14.60"],["5NJV_A_SAMA301_0","NS5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.29A","5njvA-3s69A:undetectable","5njvA-3s69A:20.65"],["5NJV_B_SAMB301_0","NS5","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.30A","5njvB-3s69A:undetectable","5njvB-3s69A:20.65"],["5WZ1_B_SAMB601_0","NS5 METHYLTRANSFERASE","3s69","THROMBIN-LIKE ENZYME DEFIBRASE","Gloydius saxatilis",6,"GLY A 139;GLY A  43;GLY A 196;GLY A 193;THR A  53;VAL A  51","None","1.33A","5wz1B-3s69A:undetectable","5wz1B-3s69A:20.69"]]