SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 VAL A 225
ASN A 206
ILE A 190
ASN A 191
 None
 0.94A 1e06A-3s6bA:
undetectable		 1e06A-3s6bA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 LEU A  68
SER A  69
ASP A 137
PHE A 162
 None
 1.12A 1ismB-3s6bA:
undetectable		 1ismB-3s6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_2
(ESTROGEN RECEPTOR
BETA)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ASP A 204
LEU A 205
HIS A 144
 FE  A 370 (-3.0A)
None
None
 0.68A 1qknA-3s6bA:
undetectable		 1qknA-3s6bA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		5 / 8 ALA A 115
THR A 348
HIS A 335
THR A 336
ILE A 112
 None
 1.50A 1utdF-3s6bA:
undetectable
1utdG-3s6bA:
undetectable		 1utdF-3s6bA:
12.03
1utdG-3s6bA:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 CYH A 167
HIS A 176
HIS A 277
TRP A 320
 None
 0.71A 1yvmA-3s6bA:
37.0		 1yvmA-3s6bA:
31.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YVM_A_TMGA501_1
(METHIONINE
AMINOPEPTIDASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 TYR A 159
CYH A 167
HIS A 176
HIS A 277
 None
 0.45A 1yvmA-3s6bA:
37.0		 1yvmA-3s6bA:
31.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_C_SAMC530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 TYR A 160
GLU A  92
ASN A 279
 None
 1.02A 2y7hC-3s6bA:
undetectable		 2y7hC-3s6bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_A_CHDA153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 5 ILE A 346
THR A 361
PHE A 359
PHE A 333
 None
 1.38A 3em0A-3s6bA:
undetectable		 3em0A-3s6bA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HLW_B_CE3B302_2
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 CYH A 166
PRO A 163
ASP A 137
 None
 0.95A 3hlwB-3s6bA:
undetectable		 3hlwB-3s6bA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ASP A 124
SER A 354
ARG A 350
 GOL  A 371 (-3.8A)
None
None
 0.92A 3loqA-3s6bA:
undetectable		 3loqA-3s6bA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 HIS A 284
SER A 330
ASN A 206
 None
 0.77A 3s8pB-3s6bA:
undetectable		 3s8pB-3s6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ARG A 182
ARG A  64
TRP A  66
 None
 1.20A 4cpzE-3s6bA:
undetectable		 4cpzE-3s6bA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ARG A 182
ARG A  64
TRP A  66
 None
 1.19A 4cpzF-3s6bA:
undetectable		 4cpzF-3s6bA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PM5_A_CE3A301_2
(BETA-LACTAMASE
CTX-M-14)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 CYH A 166
PRO A 163
ASP A 137
 None
 0.98A 4pm5A-3s6bA:
undetectable		 4pm5A-3s6bA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 6 PRO A 356
ILE A 214
VAL A 225
THR A 361
 None
 1.08A 4xe5A-3s6bA:
undetectable		 4xe5A-3s6bA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_E_ACTE403_0
(PROTON-GATED ION
CHANNEL)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 ARG A 350
TYR A 209
GLU A 207
 None
 0.52A 4zzbE-3s6bA:
undetectable		 4zzbE-3s6bA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		3 / 3 HIS A 284
SER A 330
ASN A 206
 None
 0.82A 5cprB-3s6bA:
undetectable		 5cprB-3s6bA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 THR A 336
SER A 195
SER A 155
ALA A 115
 None
 1.10A 5l5fY-3s6bA:
undetectable
5l5fZ-3s6bA:
undetectable		 5l5fY-3s6bA:
20.22
5l5fZ-3s6bA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNW_D_GCSD302_1
(25 KDA PROTEIN
ELICITOR)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 GLY A 269
HIS A 270
ASP A 204
HIS A 176
 None
FE  A 370 (-3.7A)
FE  A 370 (-3.0A)
None
 0.69A 5nnwD-3s6bA:
undetectable		 5nnwD-3s6bA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NO9_D_95ZD302_1
(25 KDA PROTEIN
ELICITOR)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 7 GLY A 269
HIS A 270
ASP A 204
HIS A 176
 None
FE  A 370 (-3.7A)
FE  A 370 (-3.0A)
None
 0.71A 5no9D-3s6bA:
undetectable		 5no9D-3s6bA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 3s6b METHIONINE
AMINOPEPTIDASE
(Plasmodium
falciparum) 		4 / 8 ARG A 141
THR A 136
PRO A 179
ILE A 190
 None
 1.03A 6a4iA-3s6bA:
undetectable		 6a4iA-3s6bA:
23.17