SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXD_A_ACRA732_1
(ALPHA AMYLASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 9 GLY A 153
GLU A 180
GLY A 179
GLY A 184
ASP A 183
 None
 1.18A 1mxdA-3s6hA:
undetectable		 1mxdA-3s6hA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 10 LEU A 348
VAL A 412
VAL A 423
LEU A 433
TYR A 353
 None
 1.29A 1sv5A-3s6hA:
undetectable		 1sv5A-3s6hA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T87_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 7 TYR A 324
THR A 436
LEU A 437
VAL A 312
ILE A 344
 None
GLU  A 501 (-3.8A)
GLU  A 501 ( 4.1A)
None
None
 1.27A 1t87B-3s6hA:
undetectable		 1t87B-3s6hA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 9 PHE A  32
PHE A 279
LEU A 274
SER A 265
LEU A  64
 None
 1.36A 1wrkA-3s6hA:
undetectable
1wrkB-3s6hA:
undetectable		 1wrkA-3s6hA:
11.75
1wrkB-3s6hA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1O_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 9 TYR A 324
THR A 436
LEU A 437
VAL A 312
ILE A 344
 None
GLU  A 501 (-3.8A)
GLU  A 501 ( 4.1A)
None
None
 1.27A 2a1oB-3s6hA:
undetectable		 2a1oB-3s6hA:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOI_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 5 GLY A 129
PRO A  71
VAL A  73
ILE A 174
 None
 0.92A 2aoiA-3s6hA:
undetectable		 2aoiA-3s6hA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 5 ALA A 230
ASN A 228
ILE A 227
ASP A 232
 None
 0.99A 2h4jA-3s6hA:
undetectable		 2h4jA-3s6hA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 6 LEU A 257
LEU A 260
ILE A 288
ARG A 289
 None
 1.07A 2rlfB-3s6hA:
undetectable
2rlfC-3s6hA:
undetectable		 2rlfB-3s6hA:
6.90
2rlfC-3s6hA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 8 THR A  70
PRO A  71
VAL A  72
ALA A 166
 None
 1.15A 2v41G-3s6hA:
2.4
2v41H-3s6hA:
2.2		 2v41G-3s6hA:
19.57
2v41H-3s6hA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WA2_A_SAMA1248_0
(NON-STRUCTURAL
PROTEIN 5)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 12 GLY A 212
GLY A 214
THR A 211
LEU A 210
VAL A  49
 None
 1.12A 2wa2A-3s6hA:
undetectable		 2wa2A-3s6hA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_A_IBPA1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 7 GLY A 153
GLY A 179
THR A 185
ARG A 151
 None
 0.72A 2wd9A-3s6hA:
2.0		 2wd9A-3s6hA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_B_IBPB1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 8 GLY A 153
GLY A 179
THR A 185
ARG A 151
 None
 0.67A 2wd9B-3s6hA:
undetectable		 2wd9B-3s6hA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		3 / 3 TRP A 325
VAL A 372
ARG A 370
 None
 0.93A 3b0wA-3s6hA:
undetectable		 3b0wA-3s6hA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 8 PHE A 139
ARG A 136
GLY A 179
VAL A 187
 None
 1.15A 3bgdB-3s6hA:
undetectable		 3bgdB-3s6hA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 8 SER A 226
ASP A 222
ASP A 232
ASP A 378
 None
 1.26A 3havA-3s6hA:
undetectable		 3havA-3s6hA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 9 PRO A 155
VAL A 144
LEU A  98
ASN A 188
ILE A 189
 None
 1.40A 4c66A-3s6hA:
undetectable		 4c66A-3s6hA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 7 GLU A 273
GLU A 277
GLY A 212
ARG A 270
 None
 1.01A 4fgzA-3s6hA:
2.8		 4fgzA-3s6hA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L6V_1_PQN12001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
FUSION PROTEIN OF
PHOTOSYSTEM I
SUBUNIT III AND
SUBUNIT IX)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 11 GLY A 137
ALA A 176
LEU A 178
GLY A 179
ALA A  87
 None
 1.19A 4l6v1-3s6hA:
undetectable
4l6v6-3s6hA:
undetectable		 4l6v1-3s6hA:
21.00
4l6v6-3s6hA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 12 LEU A  57
ALA A 191
VAL A  74
GLY A  46
GLY A  76
 None
 1.02A 4rn6B-3s6hA:
undetectable		 4rn6B-3s6hA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 5 GLY A 285
THR A 286
GLY A 214
GLU A 277
 None
 0.99A 4v20A-3s6hA:
undetectable		 4v20A-3s6hA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		5 / 10 GLY A  46
ASP A  53
ALA A  60
ILE A  43
PRO A 271
 None
 1.20A 4xj7A-3s6hA:
undetectable
4xj7B-3s6hA:
undetectable		 4xj7A-3s6hA:
22.34
4xj7B-3s6hA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 7 SER A 267
ASP A 232
GLY A 291
THR A 336
 None
 1.06A 5btfA-3s6hA:
undetectable
5btfC-3s6hA:
undetectable
5btfD-3s6hA:
2.5		 5btfA-3s6hA:
25.79
5btfC-3s6hA:
25.79
5btfD-3s6hA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		3 / 3 PRO A 261
SER A 263
SER A 264
 None
 0.42A 6bpyA-3s6hA:
undetectable		 6bpyA-3s6hA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		4 / 6 GLY A 285
THR A 269
ARG A 289
SER A 265
 None
 1.09A 6jogA-3s6hA:
5.1		 6jogA-3s6hA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE
(Maricaulis
maris) 		3 / 3 ASP A 259
LEU A 260
ARG A  39
 None
 0.86A 7dfrA-3s6hA:
undetectable		 7dfrA-3s6hA:
15.63