SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AEG_A_4APA296_1
(CYTOCHROME C
PEROXIDASE)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 HIS A 180
GLY A 217
GLY A 153
MET A 156
 None
 0.87A 1aegA-3s6jA:
undetectable		 1aegA-3s6jA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 GLY A 247
ASP A 277
SER A 216
ALA A 274
 None
CA  A   4 ( 4.4A)
None
CA  A   4 ( 4.5A)
 0.99A 1gxsA-3s6jA:
undetectable
1gxsB-3s6jA:
undetectable		 1gxsA-3s6jA:
17.69
1gxsB-3s6jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_C_BEZC602_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 9 GLY A 247
PRO A 249
ASP A 277
SER A 216
ALA A 274
 None
None
CA  A   4 ( 4.4A)
None
CA  A   4 ( 4.5A)
 1.23A 1gxsC-3s6jA:
0.0
1gxsD-3s6jA:
0.0		 1gxsC-3s6jA:
17.69
1gxsD-3s6jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 ALA A 258
GLY A 288
THR A 287
ALA A 286
ASP A 266
 None
 1.07A 2f16H-3s6jA:
undetectable
2f16I-3s6jA:
undetectable		 2f16H-3s6jA:
21.24
2f16I-3s6jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GLU_A_SAMA301_0
(YCGJ)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 294
GLY A 116
ASP A 273
ALA A 274
GLU A 300
 None
CA  A   4 ( 4.5A)
CA  A   4 (-2.5A)
CA  A   4 ( 4.5A)
None
 0.91A 2gluA-3s6jA:
2.6		 2gluA-3s6jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 305
ALA A 304
GLY A 299
ILE A 298
ILE A 275
 None
 0.91A 2o4sB-3s6jA:
undetectable		 2o4sB-3s6jA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE A 191
GLN A 124
ASN A 125
GLY A 116
LEU A 194
 None
None
None
CA  A   4 ( 4.5A)
None
 1.13A 2zw9A-3s6jA:
2.2		 2zw9A-3s6jA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 294
GLY A 116
ASP A 273
ALA A 274
GLU A 300
 None
CA  A   4 ( 4.5A)
CA  A   4 (-2.5A)
CA  A   4 ( 4.5A)
None
 0.95A 3g8bA-3s6jA:
undetectable		 3g8bA-3s6jA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 LEU A 155
SER A 159
ARG A 162
PRO A 249
 None
 1.19A 3onnA-3s6jA:
14.7		 3onnA-3s6jA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S43_A_478A401_2
(PROTEASE)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 GLY A 305
ALA A 304
GLY A 299
ILE A 298
ILE A 275
 None
 0.99A 3s43B-3s6jA:
undetectable		 3s43B-3s6jA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VNS_A_DVAA602_0
(NRPS ADENYLATION
PROTEIN CYTC1)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ASP A 273
GLY A 150
THR A 117
LYS A 248
 CA  A   4 (-2.5A)
CA  A   4 ( 4.7A)
None
None
 1.12A 3vnsA-3s6jA:
2.3		 3vnsA-3s6jA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_1
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 LEU A 291
ASP A 273
ALA A 281
PHE A 254
LEU A 231
 None
CA  A   4 (-2.5A)
None
None
None
 1.21A 4iaqA-3s6jA:
undetectable		 4iaqA-3s6jA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 LEU A 231
ALA A 228
LEU A 226
THR A 119
SER A 121
 None
 1.50A 4ikjA-3s6jA:
undetectable
4ikjB-3s6jA:
undetectable		 4ikjA-3s6jA:
19.47
4ikjB-3s6jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 7 SER A 121
LEU A 231
ALA A 228
LEU A 226
THR A 119
 None
 1.47A 4ikkA-3s6jA:
undetectable
4ikkB-3s6jA:
undetectable		 4ikkA-3s6jA:
19.47
4ikkB-3s6jA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 6 ASN A 225
ASP A 120
GLY A 294
THR A 215
 None
 0.95A 4l1aB-3s6jA:
undetectable		 4l1aB-3s6jA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 ILE A 323
VAL A 270
VAL A 289
ARG A 308
 None
 1.20A 4m6tA-3s6jA:
undetectable		 4m6tA-3s6jA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMB_A_SREA603_1
(TRANSPORTER)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 9 ASP A 115
PRO A 195
ALA A 193
GLY A 294
SER A 121
 CA  A   4 (-4.7A)
None
None
None
None
 1.35A 4mmbA-3s6jA:
0.7		 4mmbA-3s6jA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N49_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 GLY A 272
GLY A 290
THR A 117
LEU A 114
LEU A 201
 None
 1.01A 4n49A-3s6jA:
undetectable		 4n49A-3s6jA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DL9_A_ACTA214_0
(LYSOZYME C)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ASP A 115
TRP A 129
VAL A 126
ALA A 127
 CA  A   4 (-4.7A)
None
None
None
 1.35A 5dl9A-3s6jA:
undetectable		 5dl9A-3s6jA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_2_PQN2843_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 12 ILE A 323
PHE A 254
SER A 216
ILE A 275
ALA A 274
 None
None
None
None
CA  A   4 ( 4.5A)
 1.31A 5oy02-3s6jA:
undetectable		 5oy02-3s6jA:
19.77