SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 6 LEU A 213
ILE A 271
ASP A 276
PRO A 274
 None
 1.23A 1ditH-3s6kA:
undetectable
1ditP-3s6kA:
undetectable		 1ditH-3s6kA:
19.79
1ditP-3s6kA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_1
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 4 THR A 272
LEU A 213
VAL A  52
LEU A  53
 None
 1.09A 1fbmB-3s6kA:
undetectable		 1fbmB-3s6kA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		6 / 10 VAL A  52
VAL A 177
VAL A  76
ASN A 130
ILE A 211
LEU A  60
 None
 1.33A 1fe2A-3s6kA:
undetectable		 1fe2A-3s6kA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 4 THR A 272
LEU A 213
VAL A  52
LEU A  53
 None
 0.94A 1mz9D-3s6kA:
undetectable		 1mz9D-3s6kA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 7 LEU A  67
VAL A  70
GLY A  71
ILE A  15
 None
 0.80A 1p2yA-3s6kA:
undetectable		 1p2yA-3s6kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 LEU A  60
LEU A 123
GLY A  79
SER A 119
ALA A 198
 None
 1.27A 2bm9B-3s6kA:
3.7		 2bm9B-3s6kA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		3 / 3 ASP A 150
THR A 184
PRO A 185
 None
 0.65A 2pynB-3s6kA:
undetectable		 2pynB-3s6kA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_4
(PROTEASE RETROPEPSIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		3 / 3 ASP A 150
THR A 184
PRO A 185
 None
 0.66A 2qakB-3s6kA:
undetectable		 2qakB-3s6kA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 7 GLU A 295
ARG A 293
GLU A 340
ARG A 343
 None
 1.24A 2zt7A-3s6kA:
2.7		 2zt7A-3s6kA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABK_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 5 ILE A 360
TYR A 337
ARG A 299
THR A 301
 None
 1.47A 3abkN-3s6kA:
undetectable
3abkW-3s6kA:
undetectable		 3abkN-3s6kA:
22.74
3abkW-3s6kA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_D_ADND500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 5 LEU A 121
GLN A 129
HIS A  78
LEU A  53
 None
 1.14A 3ce6D-3s6kA:
undetectable		 3ce6D-3s6kA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 7 LEU A 362
ARG A 385
SER A 318
GLY A 377
 None
 0.92A 3hcrB-3s6kA:
3.4		 3hcrB-3s6kA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		4 / 6 LEU A 277
LEU A 281
PRO A  74
LEU A  72
 None
 0.88A 3q1eA-3s6kA:
undetectable
3q1eC-3s6kA:
undetectable		 3q1eA-3s6kA:
14.25
3q1eC-3s6kA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 VAL A  46
LEU A  57
LEU A  64
VAL A  52
GLY A  50
 None
 1.12A 3rr3C-3s6kA:
undetectable		 3rr3C-3s6kA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 VAL A  46
LEU A  57
LEU A  64
VAL A  52
GLY A  50
 None
 1.12A 3rr3D-3s6kA:
undetectable		 3rr3D-3s6kA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKA_A_SAMA400_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 GLY A  50
GLY A  79
HIS A  78
ASP A  55
GLU A  58
 None
 1.37A 3tkaA-3s6kA:
3.0		 3tkaA-3s6kA:
25.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PB1_A_RBVA501_1
(NUPC FAMILY PROTEIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 GLY A 294
TYR A  31
LEU A 260
SER A 229
ILE A 230
 None
 1.33A 4pb1A-3s6kA:
undetectable		 4pb1A-3s6kA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 VAL A  76
LEU A 281
VAL A  48
LEU A 213
SER A  63
 None
 1.38A 4po0A-3s6kA:
undetectable		 4po0A-3s6kA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 LEU A  57
LEU A  60
LYS A 122
LEU A 123
ALA A 132
 None
 1.16A 4wg0B-3s6kA:
undetectable
4wg0C-3s6kA:
undetectable
4wg0D-3s6kA:
undetectable		 4wg0B-3s6kA:
3.33
4wg0C-3s6kA:
3.33
4wg0D-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 LEU A  57
LEU A  60
LYS A 122
LEU A 123
ALA A 132
 None
 1.17A 4wg0D-3s6kA:
undetectable
4wg0E-3s6kA:
undetectable
4wg0F-3s6kA:
undetectable		 4wg0D-3s6kA:
3.33
4wg0E-3s6kA:
3.33
4wg0F-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_E_CHDE104_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		6 / 11 ALA A 132
GLU A 125
LYS A 122
LEU A 123
LEU A  57
LEU A  60
 None
 1.38A 4wg0C-3s6kA:
undetectable
4wg0D-3s6kA:
undetectable
4wg0E-3s6kA:
undetectable		 4wg0C-3s6kA:
3.33
4wg0D-3s6kA:
3.33
4wg0E-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_G_CHDG103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		6 / 11 ALA A 132
GLU A 125
LYS A 122
LEU A 123
LEU A  57
LEU A  60
 None
 1.40A 4wg0E-3s6kA:
undetectable
4wg0F-3s6kA:
undetectable
4wg0G-3s6kA:
undetectable		 4wg0E-3s6kA:
3.33
4wg0F-3s6kA:
3.33
4wg0G-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 ALA A 132
GLU A 125
LEU A 123
LEU A  57
LEU A  60
 None
 0.96A 4wg0G-3s6kA:
undetectable
4wg0H-3s6kA:
undetectable
4wg0I-3s6kA:
undetectable		 4wg0G-3s6kA:
3.33
4wg0H-3s6kA:
3.33
4wg0I-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 LEU A  57
LEU A  60
LYS A 122
LEU A 123
ALA A 132
 None
 1.14A 4wg0J-3s6kA:
undetectable
4wg0K-3s6kA:
undetectable
4wg0L-3s6kA:
undetectable		 4wg0J-3s6kA:
3.33
4wg0K-3s6kA:
3.33
4wg0L-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_K_CHDK103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 ALA A 132
LYS A 122
LEU A 123
LEU A  57
LEU A  60
 None
 1.13A 4wg0I-3s6kA:
undetectable
4wg0J-3s6kA:
undetectable
4wg0K-3s6kA:
undetectable		 4wg0I-3s6kA:
3.33
4wg0J-3s6kA:
3.33
4wg0K-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 11 ALA A 132
GLU A 125
LEU A 123
LEU A  57
LEU A  60
 None
 1.00A 4wg0K-3s6kA:
undetectable
4wg0L-3s6kA:
undetectable
4wg0M-3s6kA:
undetectable		 4wg0K-3s6kA:
3.33
4wg0L-3s6kA:
3.33
4wg0M-3s6kA:
3.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0S_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 12 VAL A  70
LEU A  32
LEU A  19
ILE A  15
PHE A 282
 None
 0.90A 4y0sA-3s6kA:
2.5		 4y0sA-3s6kA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		3 / 3 TYR A 337
ARG A 299
THR A 301
 None
 0.84A 5z84J-3s6kA:
undetectable		 5z84J-3s6kA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_T_PCFT101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		5 / 10 VAL A 141
SER A 169
ALA A 172
ASN A 120
VAL A 177
 None
 1.37A 6hu9L-3s6kA:
undetectable
6hu9P-3s6kA:
undetectable
6hu9T-3s6kA:
undetectable		 6hu9L-3s6kA:
24.36
6hu9P-3s6kA:
20.18
6hu9T-3s6kA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3s6k ACETYLGLUTAMATE
KINASE
(Xanthomonas
campestris) 		3 / 3 ILE A 137
THR A 138
PRO A 165
 None
 0.40A 6ncsA-3s6kA:
undetectable		 6ncsA-3s6kA:
21.78