SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		3 / 3 PHE A 123
TYR A  36
TYR A  30
 None
 0.89A 1x70B-3s6mA:
undetectable		 1x70B-3s6mA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		4 / 5 PHE A  27
PHE A  98
PHE A  41
VAL A   2
 None
 1.22A 2lh6A-3s6mA:
undetectable		 2lh6A-3s6mA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_2
(RENIN)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		4 / 8 SER A  93
THR A  23
LEU A  76
THR A  64
 None
None
PEG  A 165 ( 4.0A)
None
 1.13A 2v0zO-3s6mA:
undetectable		 2v0zO-3s6mA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		5 / 12 PHE A  99
GLY A  52
HIS A  42
ILE A 100
ASN A 101
 EDO  A 164 (-3.5A)
None
None
None
None
 1.41A 3a25A-3s6mA:
undetectable		 3a25A-3s6mA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A  11
VAL A 139
ASP A 131
GLY A 129
THR A   6
 None
 1.05A 3bwcA-3s6mA:
undetectable		 3bwcA-3s6mA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9X_A_NIMA1_1
(LACTOTRANSFERRIN')		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		4 / 4 GLU A 158
GLY A  38
THR A  39
GLU A  56
 None
 1.24A 3e9xA-3s6mA:
undetectable		 3e9xA-3s6mA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW1_A_STIA233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		5 / 10 PHE A  27
GLY A  52
GLY A  53
THR A  39
TYR A  36
 None
 1.49A 3fw1A-3s6mA:
undetectable		 3fw1A-3s6mA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		4 / 5 LEU A  15
GLY A 124
PHE A 123
PHE A  27
 None
PEG  A 165 (-3.7A)
None
None
 1.10A 3smtA-3s6mA:
undetectable		 3smtA-3s6mA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		5 / 11 PHE A  98
PHE A  27
PHE A  41
ILE A 157
LEU A  13
 None
 1.14A 3t3rA-3s6mA:
undetectable		 3t3rA-3s6mA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		4 / 8 ALA A  86
ILE A 157
GLY A  54
THR A  64
 EDO  A 164 ( 3.9A)
None
None
None
 0.86A 4r20A-3s6mA:
undetectable		 4r20A-3s6mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 3s6m PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
(Burkholderia
pseudomallei) 		3 / 3 ASP A 154
LEU A  59
GLY A  58
 None
 0.51A 4xmfA-3s6mA:
undetectable		 4xmfA-3s6mA:
22.01