SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s6x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JZS_A_MRCA1301_1 (ISOLEUCYL-TRNA SYNTHETASE)	3s6x	OUTER CAPSID PROTEIN SIGMA-1 (Mammalian orthoreovirus)	5 / 11	GLY A 330 HIS A 438 GLY A 363 ASP A 362 ILE A 401	None	1.22A	1jzsA-3s6xA: undetectable	1jzsA-3s6xA: 18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SKX_A_RFPA1_1 (ORPHAN NUCLEAR RECEPTOR PXR)	3s6x	OUTER CAPSID PROTEIN SIGMA-1 (Mammalian orthoreovirus)	5 / 12	VAL A 430 LEU A 426 TRP A 333 ILE A 350 PHE A 370	None	1.47A	1skxA-3s6xA: undetectable	1skxA-3s6xA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_A_URFA999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3s6x	OUTER CAPSID PROTEIN SIGMA-1 (Mammalian orthoreovirus)	4 / 5	MET A 309 ALA A 301 TYR A 298 ILE A 300	None	1.18A	1upfA-3s6xA: undetectable	1upfA-3s6xA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_C_URFC999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3s6x	OUTER CAPSID PROTEIN SIGMA-1 (Mammalian orthoreovirus)	4 / 5	MET A 309 ALA A 301 TYR A 298 ILE A 300	None	1.11A	1upfC-3s6xA: undetectable	1upfC-3s6xA: 20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UPF_D_URFD999_1 (URACIL PHOSPHORIBOSYLTRANSF ERASE)	3s6x	OUTER CAPSID PROTEIN SIGMA-1 (Mammalian orthoreovirus)	4 / 4	MET A 309 ALA A 301 TYR A 298 ILE A 300	None	1.14A	1upfD-3s6xA: undetectable	1upfD-3s6xA: 20.63

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1JZS_A_MRCA1301_1","ISOLEUCYL-TRNA SYNTHETASE","3s6x","OUTER CAPSID PROTEIN SIGMA-1","Mammalian orthoreovirus",5,"GLY A 330;HIS A 438;GLY A 363;ASP A 362;ILE A 401","None","1.22A","1jzsA-3s6xA:undetectable","1jzsA-3s6xA:18.03"],["1SKX_A_RFPA1_1","ORPHAN NUCLEAR RECEPTOR PXR","3s6x","OUTER CAPSID PROTEIN SIGMA-1","Mammalian orthoreovirus",5,"VAL A 430;LEU A 426;TRP A 333;ILE A 350;PHE A 370","None","1.47A","1skxA-3s6xA:undetectable","1skxA-3s6xA:21.07"],["1UPF_A_URFA999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3s6x","OUTER CAPSID PROTEIN SIGMA-1","Mammalian orthoreovirus",4,"MET A 309;ALA A 301;TYR A 298;ILE A 300","None","1.18A","1upfA-3s6xA:undetectable","1upfA-3s6xA:20.63"],["1UPF_C_URFC999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3s6x","OUTER CAPSID PROTEIN SIGMA-1","Mammalian orthoreovirus",4,"MET A 309;ALA A 301;TYR A 298;ILE A 300","None","1.11A","1upfC-3s6xA:undetectable","1upfC-3s6xA:20.63"],["1UPF_D_URFD999_1","URACIL PHOSPHORIBOSYLTRANSFERASE","3s6x","OUTER CAPSID PROTEIN SIGMA-1","Mammalian orthoreovirus",4,"MET A 309;ALA A 301;TYR A 298;ILE A 300","None","1.14A","1upfD-3s6xA:undetectable","1upfD-3s6xA:20.63"]]