SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s7w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4002_1
(SERUM ALBUMIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 5 ARG A 469
ALA A 468
ALA A 455
LYS A 456
 None
 1.19A 1e7cA-3s7wA:
undetectable		 1e7cA-3s7wA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FOH_D_IPHD802_0
(PHENOL HYDROXYLASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 10 ASP A 251
MET A 269
VAL A 250
ILE A 246
TYR A 198
 None
 1.42A 1fohD-3s7wA:
undetectable		 1fohD-3s7wA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 7 GLY A 489
GLU A 485
SER A 487
HIS A 491
 None
None
None
HEC  A1007 (-3.2A)
 1.13A 2ackA-3s7wA:
undetectable		 2ackA-3s7wA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 4 PRO A 224
ASP A 191
ASP A 195
ASP A  62
 None
 1.37A 2nyuA-3s7wA:
undetectable		 2nyuA-3s7wA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 10 THR A 366
VAL A 332
SER A 441
GLY A 489
ALA A 496
 None
 1.47A 2x2iB-3s7wA:
undetectable		 2x2iB-3s7wA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_B_QPSB1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 10 THR A 366
VAL A 332
SER A 441
GLY A 489
GLN A 495
 None
 1.34A 2x2iB-3s7wA:
undetectable		 2x2iB-3s7wA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 12 GLY A 285
LEU A 286
ILE A 193
ARG A 282
GLN A 190
 None
None
HEC  A1002 ( 4.2A)
HEC  A1002 (-3.1A)
None
 1.11A 3ijdB-3s7wA:
undetectable		 3ijdB-3s7wA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 6 LEU A 356
PHE A 347
ILE A 104
ALA A 105
 None
 0.90A 3mdrA-3s7wA:
undetectable		 3mdrA-3s7wA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 12 VAL A 511
SER A 507
SER A 503
ILE A 449
LEU A 103
 None
 1.18A 3w67D-3s7wA:
undetectable		 3w67D-3s7wA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 12 VAL A 511
SER A 507
SER A 503
ILE A 449
LEU A 103
 None
 1.16A 3w68A-3s7wA:
undetectable		 3w68A-3s7wA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 ARG A 219
GLU A 165
ARG A 136
 None
 0.87A 4mwvA-3s7wA:
undetectable		 4mwvA-3s7wA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 9 PHE A 452
ALA A 455
ALA A 458
LEU A 465
VAL A 464
 None
 1.20A 4or0A-3s7wA:
2.1		 4or0A-3s7wA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 9 THR A 178
ALA A 218
GLY A 134
GLY A 135
ASP A 161
 None
 1.11A 4qwuY-3s7wA:
undetectable
4qwuZ-3s7wA:
undetectable		 4qwuY-3s7wA:
18.11
4qwuZ-3s7wA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V32_C_EF2C151_1
(CEREBLON ISOFORM 4)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 7 ASN A 181
PRO A 182
PHE A 217
PHE A 137
 HEC  A1004 ( 4.7A)
None
None
None
 1.46A 4v32C-3s7wA:
undetectable		 4v32C-3s7wA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 ARG A 322
ASP A 321
ARG A 323
 None
 0.56A 4wq4B-3s7wA:
undetectable		 4wq4B-3s7wA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_A_1N1A601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 MET A  99
ASP A 450
PHE A 452
 None
 0.95A 4xeyA-3s7wA:
undetectable		 4xeyA-3s7wA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 MET A  99
ASP A 450
PHE A 452
 None
 1.00A 4xeyB-3s7wA:
undetectable		 4xeyB-3s7wA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 12 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
None
HEC  A1008 ( 4.2A)
 1.45A 5d0yA-3s7wA:
undetectable		 5d0yA-3s7wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_B_FOLB201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		5 / 12 SER A 487
PHE A 367
THR A 366
ASN A 293
VAL A 377
 None
HEC  A1007 (-4.3A)
None
None
HEC  A1008 ( 4.2A)
 1.43A 5d0yB-3s7wA:
undetectable		 5d0yB-3s7wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 8 TRP A 329
GLU A 365
HIS A 300
THR A 289
 None
None
HEC  A1006 (-3.2A)
None
 1.47A 5hqaA-3s7wA:
undetectable		 5hqaA-3s7wA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 HIS A 223
ASN A 222
LEU A 221
 None
 0.83A 6f7lB-3s7wA:
undetectable		 6f7lB-3s7wA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_2
(-)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		4 / 8 VAL A 332
TYR A 478
TYR A 473
GLU A 341
 None
 1.26A 6gneB-3s7wA:
undetectable		 6gneB-3s7wA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3s7w EIGHT-HEME NITRITE
REDUCTASE
(Thioalkalivibrio
nitratireducens) 		3 / 3 ARG A 239
PHE A 281
PHE A 228
 HEC  A1002 (-2.8A)
None
HEC  A1002 (-3.8A)
 1.03A 6nknC-3s7wA:
4.1
6nknJ-3s7wA:
undetectable		 6nknC-3s7wA:
17.79
6nknJ-3s7wA:
8.60