SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_RALA600_1
(ESTROGEN RECEPTOR)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 12 THR A 387
ASP A 421
MET A 358
ILE A 304
LEU A 342
 None
 1.14A 1errA-3s83A:
undetectable		 1errA-3s83A:
25.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 11 GLY A 522
LEU A 314
GLY A 504
MET A 476
HIS A 512
 None
 1.41A 1iolA-3s83A:
undetectable		 1iolA-3s83A:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		6 / 12 ASP A 464
LEU A 443
GLY A 442
GLY A 411
LEU A 415
LEU A 385
 None
 1.34A 2nxeA-3s83A:
undetectable		 2nxeA-3s83A:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_0
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 12 ALA A 441
GLY A 411
ALA A 412
LEU A 433
LEU A 436
 None
 0.96A 2nyuA-3s83A:
undetectable		 2nyuA-3s83A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZT7_A_GLYA1300_0
(GLYCYL-TRNA
SYNTHETASE)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 GLU A 503
GLU A 323
GLU A 416
SER A 382
 K  A 549 ( 4.7A)
K  A 549 (-3.4A)
K  A 549 (-3.8A)
None
 1.16A 2zt7A-3s83A:
undetectable		 2zt7A-3s83A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_1
(GUANINE DEAMINASE)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		5 / 12 LEU A 325
ARG A 470
GLU A 323
ALA A 528
ASP A 446
 None
None
K  A 549 (-3.4A)
None
K  A 549 (-3.4A)
 1.35A 4aqlA-3s83A:
6.6		 4aqlA-3s83A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASN A 384
GLY A 355
ILE A 304
PHE A 341
 K  A 549 (-3.3A)
None
None
None
 0.92A 4ejjA-3s83A:
undetectable		 4ejjA-3s83A:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.10A 4feuB-3s83A:
undetectable		 4feuB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEU_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.14A 4feuF-3s83A:
undetectable		 4feuF-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.11A 4fevB-3s83A:
undetectable		 4fevB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.13A 4fevD-3s83A:
undetectable		 4fevD-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.16A 4fevF-3s83A:
undetectable		 4fevF-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4fewB-3s83A:
undetectable		 4fewB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4fewD-3s83A:
undetectable		 4fewD-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4fewF-3s83A:
undetectable		 4fewF-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEX_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.19A 4fexB-3s83A:
undetectable		 4fexB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.12A 4gkhB-3s83A:
undetectable		 4gkhB-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.12A 4gkhD-3s83A:
undetectable		 4gkhD-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_F_KANF301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.14A 4gkhF-3s83A:
undetectable		 4gkhF-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 7 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4gkhG-3s83A:
undetectable		 4gkhG-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_J_KANJ301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 6 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.15A 4gkhJ-3s83A:
undetectable		 4gkhJ-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_A_KANA301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.13A 4gkiA-3s83A:
undetectable		 4gkiA-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_C_KANC301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 8 ASP A 469
ASP A 446
ASP A 339
GLU A 503
 None
K  A 549 (-3.4A)
None
K  A 549 ( 4.7A)
 1.16A 4gkiC-3s83A:
undetectable		 4gkiC-3s83A:
24.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		4 / 6 GLU A 503
GLU A 323
GLU A 416
SER A 382
 K  A 549 ( 4.7A)
K  A 549 (-3.4A)
K  A 549 (-3.8A)
None
 1.37A 4kr3A-3s83A:
undetectable		 4kr3A-3s83A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 3s83 GGDEF FAMILY PROTEIN
(Caulobacter
vibrioides) 		3 / 3 THR A 402
ALA A 363
ASN A 406
 None
 0.54A 5ersA-3s83A:
undetectable		 5ersA-3s83A:
21.93