SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s88'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3s88 16F6 - HEAVY CHAIN
ENVELOPE
GLYCOPROTEIN
(Mus
musculus;
Sudan
ebolavirus) 		4 / 7 TYR H  31
VAL I  45
ILE I  48
GLY I  36
 None
 0.95A 11gsA-3s88H:
undetectable		 11gsA-3s88H:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 4 THR J 565
LEU J 561
LEU J 554
GLN J 551
 None
 1.07A 1fbmA-3s88J:
undetectable		 1fbmA-3s88J:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FKP_A_NVPA999_1
(HIV-1 RT, A-CHAIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		5 / 11 PRO I  34
LEU J 561
VAL I  66
VAL I 180
GLY I  67
 None
 1.15A 1fkpA-3s88I:
undetectable		 1fkpA-3s88I:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		5 / 11 PRO I  34
LEU J 561
VAL I  66
VAL I 180
GLY I  67
 None
 1.17A 1lwcA-3s88I:
undetectable		 1lwcA-3s88I:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3s88 16F6 - HEAVY CHAIN
(Mus
musculus) 		3 / 3 LYS H 214
TYR H 128
PRO H 129
 None
 1.42A 2j9cC-3s88H:
undetectable		 2j9cC-3s88H:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2P_B_DHIB24_0
(INSULIN B CHAIN)		 3s88 16F6 - HEAVY CHAIN
(Mus
musculus) 		3 / 3 TYR H 181
GLY H 150
PHE H 152
 None
 0.72A 2m2pB-3s88H:
undetectable		 2m2pB-3s88H:
6.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_B_BEZB143_0
(PUTATIVE REDOX
PROTEIN)		 3s88 16F6 - HEAVY CHAIN
ENVELOPE
GLYCOPROTEIN
(Mus
musculus;
Sudan
ebolavirus) 		4 / 6 ARG H  98
TYR H 101
THR I  46
ALA H  28
 None
 1.45A 2ql8A-3s88H:
undetectable
2ql8B-3s88H:
undetectable		 2ql8A-3s88H:
21.40
2ql8B-3s88H:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		5 / 9 PHE I 153
ALA I 152
TYR I 151
GLY I  91
GLY I 149
 None
 1.20A 2v7bA-3s88I:
undetectable		 2v7bA-3s88I:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_B_BEZB1529_0
(BENZOATE-COENZYME A
LIGASE)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		5 / 9 PHE I 153
ALA I 152
TYR I 151
GLY I  91
GLY I 149
 None
 1.21A 2v7bB-3s88I:
undetectable		 2v7bB-3s88I:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 3s88 16F6 - HEAVY CHAIN
ENVELOPE
GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN
(Mus
musculus;
Sudan
ebolavirus;
Sudan
ebolavirus) 		3 / 3 LYS H  77
ILE I  48
PHE J 592
 None
 0.92A 3j7zS-3s88H:
undetectable
3j7za-3s88H:
undetectable		 3j7zS-3s88H:
19.59
3j7za-3s88H:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 3s88 16F6 - HEAVY CHAIN
(Mus
musculus) 		3 / 3 PHE H  35
TYR H  59
LEU H  20
 None
 0.79A 3keeB-3s88H:
undetectable		 3keeB-3s88H:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 3s88 16F6 - HEAVY CHAIN
(Mus
musculus) 		3 / 3 PHE H  35
TYR H  59
LEU H  20
 None
 0.71A 3sueB-3s88H:
undetectable		 3sueB-3s88H:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3s88 16F6 - HEAVY CHAIN
ENVELOPE
GLYCOPROTEIN
(Mus
musculus;
Sudan
ebolavirus) 		5 / 12 PHE H  27
SER H  25
LEU H   4
VAL H   5
THR I  46
 None
 1.14A 4eckA-3s88H:
undetectable		 4eckA-3s88H:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_A_NCTA501_1
(CYTOCHROME P450 2A13)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 7 PHE I 160
PHE I 176
ALA I  82
LEU I 111
 None
 0.88A 4ejgA-3s88I:
undetectable		 4ejgA-3s88I:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_C_NCTC501_1
(CYTOCHROME P450 2A13)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 7 PHE I 160
PHE I 176
ALA I  82
LEU I 111
 None
 0.93A 4ejgC-3s88I:
undetectable		 4ejgC-3s88I:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 4 ILE I  79
ARG I  85
TYR I 109
GLU I 178
 None
 1.35A 4zzbD-3s88I:
undetectable		 4zzbD-3s88I:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 5 ILE I  79
ARG I  85
TYR I 109
GLU I 178
 None
 1.25A 4zzcE-3s88I:
undetectable		 4zzcE-3s88I:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBM_A_NVPA601_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		5 / 11 PRO I  34
LEU J 561
VAL I  66
VAL I 180
GLY I  67
 None
 1.19A 5hbmA-3s88I:
undetectable		 5hbmA-3s88I:
19.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5JQ7_B_T0RB705_1
(ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN
1,ENVELOPE
GLYCOPROTEIN 1
ENVELOPE
GLYCOPROTEIN 2)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		6 / 7 VAL I  66
LEU I  68
GLU I 100
ALA I 101
LEU I 184
LEU I 186
 None
 0.53A 5jq7A-3s88I:
28.5		 5jq7A-3s88I:
63.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		8 / 10 VAL I  66
ALA I 101
LEU I 184
LEU I 186
LEU J 515
TYR J 517
THR J 519
LEU J 558
 None
 0.71A 6f5uA-3s88I:
28.2
6f5uB-3s88I:
undetectable		 6f5uA-3s88I:
74.39
6f5uB-3s88I:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		9 / 12 VAL I  66
LEU I  68
GLU I 100
ALA I 101
GLY I 102
LEU I 186
LEU J 515
TYR J 517
THR J 519
 None
 0.66A 6f6iA-3s88I:
27.3
6f6iB-3s88I:
undetectable		 6f6iA-3s88I:
74.39
6f6iB-3s88I:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		9 / 12 VAL I  66
LEU I  68
GLU I 100
ALA I 101
GLY I 102
LEU I 186
TYR J 517
THR J 519
LEU J 558
 None
 0.68A 6f6iA-3s88I:
27.3
6f6iB-3s88I:
undetectable		 6f6iA-3s88I:
74.39
6f6iB-3s88I:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6N_A_SREA508_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		6 / 10 VAL I  66
ALA I 101
LEU I 184
LEU I 186
TYR J 517
LEU J 558
 None
 0.72A 6f6nA-3s88I:
28.6
6f6nB-3s88I:
undetectable		 6f6nA-3s88I:
74.39
6f6nB-3s88I:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6F6S_B_CXQB705_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 6 VAL I  66
LEU I 184
LEU I 186
TYR J 517
 None
 0.65A 6f6sA-3s88I:
28.4
6f6sB-3s88I:
undetectable		 6f6sA-3s88I:
74.39
6f6sB-3s88I:
14.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6G9B_A_IXXA609_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN
ENVELOPE
GLYCOPROTEIN)		 3s88 ENVELOPE
GLYCOPROTEIN
(Sudan
ebolavirus) 		4 / 7 LEU I  43
VAL I  66
LEU I 184
LEU J 515
 None
 0.68A 6g9bA-3s88I:
28.3
6g9bB-3s88I:
undetectable		 6g9bA-3s88I:
74.39
6g9bB-3s88I:
14.24