SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s90'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 3s90 VINCULIN
TALIN-1
(Homo
sapiens;
Mus
musculus) 		5 / 12 ILE A  37
ALA A  92
LEU C1539
ILE A 109
LEU A  23
 None
 1.17A 1jolA-3s90A:
undetectable		 1jolA-3s90A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_A_FOLA164_0
(DIHYDROFOLATE
REDUCTASE)		 3s90 VINCULIN
TALIN-1
(Homo
sapiens;
Mus
musculus) 		5 / 12 ILE A  37
ALA A  92
LEU C1539
ILE A 109
LEU A  23
 None
 1.23A 2zzaA-3s90A:
undetectable		 2zzaA-3s90A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZA_B_FOLB164_0
(DIHYDROFOLATE
REDUCTASE)		 3s90 VINCULIN
TALIN-1
(Homo
sapiens;
Mus
musculus) 		5 / 11 ILE A  37
ALA A  92
LEU C1539
ILE A 109
LEU A  23
 None
 1.23A 2zzaB-3s90A:
undetectable		 2zzaB-3s90A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3s90 VINCULIN
(Homo
sapiens) 		4 / 4 ALA A  42
ALA A  45
ALA A  46
ALA A  49
 None
 0.11A 4oaeA-3s90A:
undetectable		 4oaeA-3s90A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLF_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3s90 VINCULIN
TALIN-1
(Homo
sapiens;
Mus
musculus) 		5 / 11 ILE A  37
ALA A  92
LEU C1539
ILE A 109
LEU A  23
 None
 1.21A 4qlfA-3s90A:
undetectable		 4qlfA-3s90A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUR_E_PFLE406_1
(PROTON-GATED ION
CHANNEL)		 3s90 VINCULIN
(Homo
sapiens) 		5 / 10 ILE A 175
ILE A 134
MET A 171
ILE A 241
ILE A 141
 None
 1.12A 5murE-3s90A:
8.0		 5murE-3s90A:
16.89