SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s99'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 5 SER A 212
THR A 213
GLU A 191
GLY A 189
 None
 1.34A 1icrA-3s99A:
undetectable
1icrB-3s99A:
undetectable		 1icrA-3s99A:
20.74
1icrB-3s99A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDU_B_CIAB2003_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		5 / 12 ALA A  69
ILE A  26
VAL A  98
ALA A  99
PHE A 102
 None
None
IOD  A 352 ( 4.1A)
None
None
 1.00A 1uduB-3s99A:
undetectable		 1uduB-3s99A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 8 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.26A 2bteD-3s99A:
1.8		 2bteD-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_A_LEUA1301_0
(LEUCYL-TRNA
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 7 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.22A 2bytA-3s99A:
2.6		 2bytA-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYT_D_LEUD1601_0
(LEUCYL-TRNA
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 7 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.22A 2bytD-3s99A:
undetectable		 2bytD-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 5 LEU A  83
PHE A  25
VAL A  55
ALA A 257
 None
 1.20A 2cizA-3s99A:
undetectable		 2cizA-3s99A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_A_ACTA653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 5 VAL A  23
THR A  57
VAL A  48
GLY A  52
 None
None
IOD  A 367 ( 4.8A)
None
 1.07A 2p2fA-3s99A:
6.2		 2p2fA-3s99A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P2F_B_ACTB653_0
(ACETYL-COENZYME A
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 4 VAL A  23
THR A  57
VAL A  48
GLY A  52
 None
None
IOD  A 367 ( 4.8A)
None
 1.08A 2p2fB-3s99A:
4.6		 2p2fB-3s99A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_1
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		3 / 3 SER A  88
ASP A 247
ASP A 211
 ADE  A 400 (-2.7A)
None
ADE  A 400 (-2.8A)
 0.80A 2plwA-3s99A:
3.5		 2plwA-3s99A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 8 TYR A  91
TYR A 122
TYR A 253
HIS A  40
 None
 1.16A 2v0gA-3s99A:
1.3		 2v0gA-3s99A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA607_1
(CHITINASE A)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 7 VAL A 135
SER A 170
THR A 298
LEU A 307
 None
 1.05A 3arrA-3s99A:
undetectable		 3arrA-3s99A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		5 / 12 VAL A 152
GLY A 150
ILE A 149
PRO A 188
SER A 212
 None
 1.27A 3bjwF-3s99A:
undetectable		 3bjwF-3s99A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QOW_A_SAMA417_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		3 / 3 THR A  57
ASP A  41
GLU A  61
 None
 0.84A 3qowA-3s99A:
2.3		 3qowA-3s99A:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_B_ACTB1114_0
(BLR5658 PROTEIN)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		3 / 3 TRP A 249
TRP A  36
THR A  87
 None
ADE  A 400 (-3.4A)
None
 1.10A 4bboB-3s99A:
undetectable		 4bboB-3s99A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD202_0
(RETINOL-BINDING
PROTEIN 2)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 5 LYS A 106
VAL A 260
TRP A 265
GLU A 108
 None
 1.46A 4qzuA-3s99A:
0.0
4qzuD-3s99A:
0.0		 4qzuA-3s99A:
16.29
4qzuD-3s99A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		3 / 3 THR A  86
THR A  87
PHE A  89
 None
 0.90A 5cxvA-3s99A:
undetectable		 5cxvA-3s99A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		5 / 12 VAL A 291
LEU A 294
ALA A 300
VAL A 132
GLY A 134
 None
 0.97A 5kirA-3s99A:
undetectable		 5kirA-3s99A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR1_B_017B101_2
(PROTEASE PR5-DRV)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 8 GLY A 134
VAL A 245
GLY A 160
ILE A 161
 None
 0.65A 5kr1B-3s99A:
undetectable		 5kr1B-3s99A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		6 / 12 ILE A 149
GLY A 150
HIS A 209
PHE A 164
ILE A 199
ALA A 195
 None
None
ADE  A 400 (-4.5A)
None
None
None
 1.43A 5n0wB-3s99A:
3.9		 5n0wB-3s99A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3s99 BASIC MEMBRANE
LIPOPROTEIN
(Brucella
abortus) 		4 / 8 TRP A 185
ASP A  33
HIS A 209
ASP A 247
 ADE  A 400 ( 3.5A)
None
ADE  A 400 (-4.5A)
None
 1.23A 6mn4C-3s99A:
undetectable		 6mn4C-3s99A:
20.60