SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3s9j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SQ5_B_PAUB6003_0
(PANTOTHENATE KINASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		5 / 10 LEU A 273
GLY A 222
TYR A 209
LEU A 286
TYR A 159
 None
GOL  A 416 ( 3.3A)
None
FMT  A 404 ( 4.9A)
FMT  A 411 (-3.9A)
 1.16A 1sq5B-3s9jA:
undetectable		 1sq5B-3s9jA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_J_BEZJ5041_0
(CES1 PROTEIN)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 4 GLY A 108
SER A  55
ILE A  79
HIS A  68
 None
 1.30A 1yajJ-3s9jA:
undetectable		 1yajJ-3s9jA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YC2_D_NCAD510_0
(NAD-DEPENDENT
DEACETYLASE 2)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 5 ALA A 161
ASN A 160
ILE A 295
ASP A 229
 None
 1.10A 1yc2D-3s9jA:
undetectable		 1yc2D-3s9jA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H4J_A_NCAA1002_0
(NAD-DEPENDENT
DEACETYLASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 5 ALA A 161
ASN A 160
ILE A 295
ASP A 229
 None
 1.02A 2h4jA-3s9jA:
undetectable		 2h4jA-3s9jA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 PRO A 324
ASN A 287
ARG A 291
 None
 0.95A 2qeuB-3s9jA:
undetectable		 2qeuB-3s9jA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 5 PHE A 107
PHE A  57
SER A 112
ILE A 165
 None
None
FMT  A 408 (-4.3A)
FMT  A 408 ( 4.1A)
 1.37A 2v0mD-3s9jA:
undetectable		 2v0mD-3s9jA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 7 LEU A 334
ASN A 335
GLU A  32
TYR A 259
 None
 1.21A 2w8yA-3s9jA:
undetectable		 2w8yA-3s9jA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		5 / 12 TYR A 217
GLY A 274
ILE A 176
GLY A 223
GLY A 222
 None
None
None
FMT  A 404 ( 3.2A)
GOL  A 416 ( 3.3A)
 1.07A 3axzA-3s9jA:
undetectable		 3axzA-3s9jA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ITA_D_AICD501_1
(D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE
DACC)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 PRO A 146
PHE A 143
ALA A 193
 FMT  A 410 ( 3.8A)
None
None
 0.68A 3itaD-3s9jA:
undetectable		 3itaD-3s9jA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 5 SER A 154
ARG A 173
ARG A 291
GLU A 309
 None
GOL  A 416 (-3.3A)
None
None
 1.35A 3k9fA-3s9jA:
undetectable
3k9fB-3s9jA:
undetectable
3k9fC-3s9jA:
undetectable		 3k9fA-3s9jA:
21.81
3k9fB-3s9jA:
21.81
3k9fC-3s9jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 GLU A 288
GLU A 278
ASN A 281
 None
 0.73A 3lp9B-3s9jA:
2.8
3lp9D-3s9jA:
2.8		 3lp9B-3s9jA:
20.86
3lp9D-3s9jA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UG8_A_IMNA2001_2
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 TYR A 353
GLU A 343
TYR A 265
 GOL  A 417 (-3.7A)
None
None
 0.85A 3ug8A-3s9jA:
undetectable		 3ug8A-3s9jA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_A_1KXA277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		5 / 10 TYR A 305
ILE A 332
VAL A 331
SER A 330
TYR A 265
 None
 1.47A 3uprA-3s9jA:
undetectable		 3uprA-3s9jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UPR_C_1KXC277_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		5 / 10 TYR A 305
ILE A 332
VAL A 331
SER A 330
TYR A 265
 None
 1.47A 3uprC-3s9jA:
undetectable		 3uprC-3s9jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR5_A_SRYA1860_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 LYS A 178
PRO A 179
LYS A 182
 None
 1.37A 4dr5L-3s9jA:
undetectable		 4dr5L-3s9jA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DR6_A_SRYA1956_1
(16S RRNA
30S RIBOSOMAL
PROTEIN S12)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 LYS A 178
PRO A 179
LYS A 182
 None
 1.44A 4dr6L-3s9jA:
undetectable		 4dr6L-3s9jA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 LYS A 178
PRO A 179
LYS A 182
 None
 1.33A 4duzL-3s9jA:
undetectable		 4duzL-3s9jA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RMJ_A_NCAA402_0
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 7 LEU A 380
LEU A  67
ILE A  84
ASP A  83
 None
 0.82A 4rmjA-3s9jA:
undetectable		 4rmjA-3s9jA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8I_C_FK5C201_1
(SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 6 LEU A 197
SER A 112
PRO A 113
GLU A  61
 None
FMT  A 408 (-4.3A)
FMT  A 408 ( 4.4A)
GOL  A 418 (-3.7A)
 1.29A 5b8iA-3s9jA:
undetectable		 5b8iA-3s9jA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EUM_B_ACTB603_0
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		4 / 4 ALA A 261
ASN A 260
ARG A 306
ILE A 332
 None
 1.02A 5eumB-3s9jA:
undetectable		 5eumB-3s9jA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U98_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		5 / 10 TYR A 305
ILE A 332
VAL A 331
SER A 330
TYR A 265
 None
 1.47A 5u98A-3s9jA:
undetectable		 5u98A-3s9jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		6 / 12 TYR A 217
GLY A 274
ILE A 176
TYR A 209
GLY A 223
GLY A 222
 None
None
None
None
FMT  A 404 ( 3.2A)
GOL  A 416 ( 3.3A)
 1.14A 5wyqB-3s9jA:
undetectable		 5wyqB-3s9jA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 THR A 323
GLU A 309
HIS A 294
 GOL  A 417 (-4.1A)
None
None
 0.71A 5xioA-3s9jA:
undetectable		 5xioA-3s9jA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 THR A 323
GLU A 309
HIS A 294
 GOL  A 417 (-4.1A)
None
None
 0.75A 5xiqB-3s9jA:
undetectable		 5xiqB-3s9jA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3s9j MEMBER OF DUF4221
FAMILY
(Bacteroides
vulgatus) 		3 / 3 THR A 323
GLU A 309
HIS A 294
 GOL  A 417 (-4.1A)
None
None
 0.72A 5xiqD-3s9jA:
undetectable		 5xiqD-3s9jA:
21.64