SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sag'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_D_T44D129_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.97A 1ictB-3sagA:
undetectable		 1ictB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 PHE A 198
TYR A 382
PRO A 200
 PHE  A 198 ( 1.3A)
TYR  A 382 ( 1.3A)
PRO  A 200 ( 1.1A)
 1.15A 1mcnA-3sagA:
undetectable
1mcnB-3sagA:
undetectable
1mcnP-3sagA:
undetectable		 1mcnA-3sagA:
17.45
1mcnB-3sagA:
17.45
1mcnP-3sagA:
2.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 1.01A 2roxB-3sagA:
undetectable		 2roxB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN3_A_ID8A1356_1
(THYROXINE-BINDING
GLOBULIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 8 LEU A 356
LEU A 297
ASN A 301
LEU A 304
 LEU  A 356 ( 0.6A)
LEU  A 297 ( 0.6A)
ASN  A 301 ( 0.6A)
LEU  A 304 ( 0.6A)
 1.10A 2xn3A-3sagA:
undetectable
2xn3B-3sagA:
undetectable		 2xn3A-3sagA:
21.97
2xn3B-3sagA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_A_ADNA1301_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 ARG A 452
ALA A 270
PRO A 267
ALA A 268
 ARG  A 452 ( 0.6A)
ALA  A 270 ( 0.0A)
PRO  A 267 ( 1.1A)
ALA  A 268 ( 0.0A)
 1.07A 2zgwA-3sagA:
undetectable		 2zgwA-3sagA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZSE_A_PAUA600_0
(PANTOTHENATE KINASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 TYR A 382
PHE A 198
ILE A 202
ASN A 353
 TYR  A 382 ( 1.3A)
PHE  A 198 ( 1.3A)
ILE  A 202 ( 0.7A)
ASN  A 353 ( 0.6A)
 1.24A 2zseA-3sagA:
undetectable		 2zseA-3sagA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CFQ_B_DIFB1_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.89A 3cfqA-3sagA:
undetectable
3cfqB-3sagA:
undetectable		 3cfqA-3sagA:
13.24
3cfqB-3sagA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 PRO A 580
LEU A 581
GLN A 505
 PRO  A 580 ( 1.1A)
LEU  A 581 ( 0.6A)
GLN  A 505 ( 0.6A)
 0.69A 3hznG-3sagA:
undetectable
3hznH-3sagA:
undetectable		 3hznG-3sagA:
17.87
3hznH-3sagA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.86A 4d7bB-3sagA:
undetectable		 4d7bB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_B_TCWB1126_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.83A 4d7bA-3sagA:
undetectable		 4d7bA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 ASP A 439
ARG A 438
ASP A 414
 ASP  A 439 ( 0.6A)
ARG  A 438 ( 0.6A)
ASP  A 414 ( 0.6A)
 0.86A 4fp9C-3sagA:
undetectable		 4fp9C-3sagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 ASP A 439
ARG A 438
ASP A 414
 ASP  A 439 ( 0.6A)
ARG  A 438 ( 0.6A)
ASP  A 414 ( 0.6A)
 0.84A 4fp9F-3sagA:
undetectable		 4fp9F-3sagA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I89_A_1FLA201_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.94A 4i89A-3sagA:
undetectable		 4i89A-3sagA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_B_IMNB201_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.94A 4ikiB-3sagA:
undetectable		 4ikiB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKJ_A_SUZA201_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.96A 4ikjA-3sagA:
undetectable
4ikjB-3sagA:
undetectable		 4ikjA-3sagA:
14.59
4ikjB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKK_B_SUZB201_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 7 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.92A 4ikkA-3sagA:
undetectable
4ikkB-3sagA:
undetectable		 4ikkA-3sagA:
14.59
4ikkB-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_B_MN9B401_0
(N-ACETYLNEURAMINATE
LYASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 SER A 293
LEU A 294
ASP A 295
LEU A 345
 SER  A 293 ( 0.0A)
LEU  A 294 ( 0.6A)
ASP  A 295 ( 0.6A)
LEU  A 345 ( 0.6A)
 0.86A 4wozA-3sagA:
undetectable
4wozB-3sagA:
undetectable		 4wozA-3sagA:
21.20
4wozB-3sagA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BOJ_A_4TXA201_1
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.95A 5bojA-3sagA:
undetectable		 5bojA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB201_0
(HYDROXYNITRILE LYASE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		5 / 11 VAL A 469
PHE A 387
ILE A 447
TYR A 410
LEU A 396
 VAL  A 469 ( 0.6A)
PHE  A 387 ( 1.3A)
ILE  A 447 ( 0.7A)
TYR  A 410 ( 1.3A)
LEU  A 396 ( 0.6A)
 1.10A 5e4dB-3sagA:
undetectable		 5e4dB-3sagA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_A_6J3A201_0
(TRANSTHYRETIN)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 6 LEU A 396
ALA A 392
LEU A 398
THR A 389
 LEU  A 396 ( 0.6A)
ALA  A 392 ( 0.0A)
LEU  A 398 ( 0.6A)
THR  A 389 ( 0.8A)
 0.91A 5l4iA-3sagA:
undetectable		 5l4iA-3sagA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		4 / 4 LEU A 544
MET A 579
ILE A 551
LEU A 512
 LEU  A 544 ( 0.6A)
MET  A 579 ( 0.0A)
ILE  A 551 ( 0.7A)
LEU  A 512 ( 0.6A)
 1.40A 5nfpA-3sagA:
undetectable		 5nfpA-3sagA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 LYS A 480
LEU A 216
ASP A 252
 LYS  A 480 ( 0.0A)
LEU  A 216 ( 0.6A)
ASP  A 252 ( 0.6A)
 0.84A 5zv2A-3sagA:
undetectable		 5zv2A-3sagA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F7L_B_ACTB505_0
(AMINE OXIDASE LKCE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 HIS A 264
ASN A 263
LEU A 262
 HIS  A 264 ( 1.0A)
ASN  A 263 ( 0.6A)
LEU  A 262 ( 0.6A)
 0.89A 6f7lB-3sagA:
undetectable		 6f7lB-3sagA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 3sag EXOSOME COMPONENT 10
(Homo
sapiens) 		3 / 3 TRP A 374
ILE A 372
ASP A 371
 TRP  A 374 ( 0.5A)
ILE  A 372 ( 0.7A)
ASP  A 371 ( 0.5A)
 0.77A 6i0y7-3sagA:
undetectable		 6i0y7-3sagA:
6.80