SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sb4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 LEU A 233
ILE A 241
ILE A 261
PRO A 262
ILE A 275
 None
 0.91A 1dyrA-3sb4A:
undetectable		 1dyrA-3sb4A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 159
VAL A 104
ILE A  76
ILE A 148
ILE A 135
 None
 1.01A 1ohrB-3sb4A:
undetectable		 1ohrB-3sb4A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_B_SAMB4001_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 HIS A 279
LEU A 251
LEU A 277
PRO A 278
ILE A 261
 None
 1.02A 1zq9B-3sb4A:
2.5		 1zq9B-3sb4A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_D_H4BD1290_1
(PTERIDINE REDUCTASE
1)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 PHE A 109
LEU A  71
LEU A  35
LEU A  56
 None
 0.74A 2bfpD-3sb4A:
undetectable		 2bfpD-3sb4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXQ_A_IMNA2001_1
(SERUM ALBUMIN)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 10 ALA A 139
PHE A 109
LEU A  56
LEU A  64
LEU A 164
 None
 1.12A 2bxqA-3sb4A:
undetectable		 2bxqA-3sb4A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 6 PHE A 140
GLN A 121
ASN A 145
ASN A  45
 None
 1.31A 2nyrA-3sb4A:
undetectable		 2nyrA-3sb4A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 LEU A 277
PRO A 278
LEU A 281
ILE A 284
 None
 0.86A 2qd4A-3sb4A:
undetectable		 2qd4A-3sb4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1498_1
(CYTOCHROME P450 3A4)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 LEU A 336
LEU A 345
PHE A 313
ALA A 307
THR A 330
 None
 1.28A 2v0mC-3sb4A:
undetectable		 2v0mC-3sb4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 308
ILE A 253
LEU A 345
LEU A 295
 None
None
None
GOL  A 354 (-3.9A)
 0.89A 3adxA-3sb4A:
undetectable		 3adxA-3sb4A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 9 LEU A 159
VAL A 104
ILE A  76
ILE A 148
ILE A 135
 None
 0.95A 3el0B-3sb4A:
undetectable		 3el0B-3sb4A:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 11 GLY A 333
ILE A 308
ALA A 312
ASP A 334
GLN A 286
 None
 0.95A 3nmuB-3sb4A:
undetectable
3nmuJ-3sb4A:
undetectable		 3nmuB-3sb4A:
22.86
3nmuJ-3sb4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 GLY A 333
ILE A 308
ALA A 312
ASP A 334
GLN A 286
 None
 1.07A 3nvkI-3sb4A:
undetectable		 3nvkI-3sb4A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A 132
GLU A 136
ALA A 139
ALA A 163
 None
 0.72A 3r9tA-3sb4A:
undetectable		 3r9tA-3sb4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 7 ILE A 132
GLU A 136
ALA A 139
ALA A 163
 None
 0.72A 3r9tB-3sb4A:
undetectable		 3r9tB-3sb4A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 4 LEU A 277
PRO A 278
LEU A 281
ILE A 284
 None
 0.91A 4f4dB-3sb4A:
undetectable		 4f4dB-3sb4A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 5 THR A 283
GLY A 285
VAL A 288
PRO A 262
 None
 1.11A 4grkA-3sb4A:
undetectable		 4grkA-3sb4A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 PHE A 289
GLY A 285
LEU A 332
PHE A 313
LEU A 281
 None
 1.30A 4xldA-3sb4A:
undetectable		 4xldA-3sb4A:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		4 / 8 ILE A  81
THR A  90
ALA A 108
LEU A  64
 None
 0.78A 5og9A-3sb4A:
undetectable		 5og9A-3sb4A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 307
GLY A 285
LYS A 328
ASP A 327
GLY A 326
 None
 1.12A 5wwsA-3sb4A:
undetectable		 5wwsA-3sb4A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3sb4 HYPOTHETICAL LEUCINE
RICH REPEAT PROTEIN
(Bacteroides
thetaiotaomicron) 		5 / 12 ALA A 307
GLY A 285
LYS A 328
ASP A 327
GLY A 326
 None
 1.14A 5wwsB-3sb4A:
undetectable		 5wwsB-3sb4A:
22.90