SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sc3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIP_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		5 / 12 ALA A 124
LEU A 101
ARG A 131
LEU A 140
LEU A  98
 None
 1.32A 1jipA-3sc3A:
undetectable		 1jipA-3sc3A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_2
(HIV-1 PROTEASE)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		5 / 9 LEU A 166
ILE A  68
ILE A  39
VAL A  51
ILE A  54
 None
 1.18A 3d1yB-3sc3A:
undetectable		 3d1yB-3sc3A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKY_A_DR7A100_2
(PROTEASE)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		5 / 9 ARG A 161
ASP A 111
ILE A  85
ILE A 141
ILE A 125
 None
 1.24A 3ekyB-3sc3A:
undetectable		 3ekyB-3sc3A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		6 / 12 LEU A 166
ILE A 141
ILE A  68
ILE A  39
VAL A  51
ILE A  54
 None
 1.12A 4q1xB-3sc3A:
undetectable		 4q1xB-3sc3A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		5 / 12 LEU A  42
ALA A  45
LEU A 128
ILE A  68
LEU A 101
 None
 1.03A 5ljeA-3sc3A:
undetectable		 5ljeA-3sc3A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA
(Shewanella
amazonensis) 		5 / 11 LEU A 241
VAL A 235
THR A 211
ALA A 206
LEU A 201
 None
 1.12A 6h1lB-3sc3A:
undetectable		 6h1lB-3sc3A:
20.22