SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sc4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ1_B_NPSB401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 8 VAL A  25
VAL A  32
ILE A  10
LEU A 144
 None
 0.93A 4jq1B-3sc4A:
undetectable		 4jq1B-3sc4A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDP_H_EVPH2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		4 / 6 GLU A  58
GLY A  12
ARG A  15
GLY A  18
 None
UNL  A 290 ( 3.3A)
UNL  A 288 (-3.7A)
EDO  A 282 (-3.8A)
 0.99A 5cdpA-3sc4A:
undetectable
5cdpB-3sc4A:
2.5		 5cdpA-3sc4A:
21.18
5cdpB-3sc4A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 VAL A 127
LEU A 144
SER A  11
THR A 238
GLY A 168
 None
 1.13A 5m5cB-3sc4A:
6.6		 5m5cB-3sc4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 10 VAL A 127
LEU A 144
SER A  11
THR A 238
GLY A 168
 None
 1.18A 5m5cE-3sc4A:
6.7		 5m5cE-3sc4A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_B_SAMB301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 12 LEU A  34
GLY A  12
ILE A  56
GLY A  18
GLY A  13
 None
UNL  A 290 ( 3.3A)
None
EDO  A 282 (-3.8A)
UNL  A 291 ( 4.4A)
 0.97A 5wyqB-3sc4A:
undetectable		 5wyqB-3sc4A:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 3sc4 SHORT CHAIN
DEHYDROGENASE
(A0QTM2 HOMOLOG)
(Mycolicibacteriu
m
thermoresistibil
e) 		5 / 9 ALA A  33
VAL A  80
ALA A  79
VAL A 127
GLY A  68
 None
 1.13A 6bklA-3sc4A:
undetectable
6bklB-3sc4A:
undetectable
6bklC-3sc4A:
undetectable
6bklD-3sc4A:
undetectable		 6bklA-3sc4A:
8.40
6bklB-3sc4A:
8.40
6bklC-3sc4A:
8.40
6bklD-3sc4A:
8.40