SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sc6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		5 / 10 PHE A 137
ALA A 133
ASN A  80
ALA A  84
ILE A  79
 None
None
None
None
NAP  A 285 (-4.5A)
 1.30A 1claA-3sc6A:
undetectable		 1claA-3sc6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_A_NIOA604_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 5 SER A 102
THR A 103
GLU A 135
GLY A 134
 None
NAP  A 285 (-4.0A)
None
None
 1.16A 1icrA-3sc6A:
undetectable
1icrB-3sc6A:
undetectable		 1icrA-3sc6A:
24.08
1icrB-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICR_B_NIOB602_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU A 135
GLY A 134
SER A 102
THR A 103
 None
None
None
NAP  A 285 (-4.0A)
 1.16A 1icrA-3sc6A:
undetectable
1icrB-3sc6A:
undetectable		 1icrA-3sc6A:
24.08
1icrB-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_C_NIOC225_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 6 SER A 102
THR A 103
GLU A 135
GLY A 134
 None
NAP  A 285 (-4.0A)
None
None
 1.15A 1icuC-3sc6A:
undetectable
1icuD-3sc6A:
undetectable		 1icuC-3sc6A:
24.08
1icuD-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_C_NIOC708_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 5 SER A 102
THR A 103
GLU A 135
GLY A 134
 None
NAP  A 285 (-4.0A)
None
None
 1.15A 1icvC-3sc6A:
undetectable
1icvD-3sc6A:
undetectable		 1icvC-3sc6A:
24.08
1icvD-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICV_D_NIOD706_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU A 135
GLY A 134
SER A 102
THR A 103
 None
None
None
NAP  A 285 (-4.0A)
 1.16A 1icvC-3sc6A:
undetectable
1icvD-3sc6A:
undetectable		 1icvC-3sc6A:
24.08
1icvD-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_B_BEZB525_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 5 GLU A 135
GLY A 134
SER A 102
THR A 103
 None
None
None
NAP  A 285 (-4.0A)
 1.16A 1kqbA-3sc6A:
undetectable
1kqbB-3sc6A:
undetectable		 1kqbA-3sc6A:
25.34
1kqbB-3sc6A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQB_D_BEZD523_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 6 GLU A 135
GLY A 134
SER A 102
THR A 103
 None
None
None
NAP  A 285 (-4.0A)
 1.15A 1kqbC-3sc6A:
undetectable
1kqbD-3sc6A:
undetectable		 1kqbC-3sc6A:
25.34
1kqbD-3sc6A:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 8 PHE A 161
ASN A 160
GLY A 155
PHE A 277
 None
 1.06A 1ykiA-3sc6A:
undetectable
1ykiB-3sc6A:
undetectable		 1ykiA-3sc6A:
24.08
1ykiB-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 8 PHE A 277
PHE A 161
ASN A 160
GLY A 155
 None
 1.09A 1ykiA-3sc6A:
undetectable
1ykiB-3sc6A:
undetectable		 1ykiA-3sc6A:
24.08
1ykiB-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 8 PHE A 161
ASN A 160
GLY A 155
PHE A 277
 None
 1.04A 1ykiC-3sc6A:
undetectable
1ykiD-3sc6A:
undetectable		 1ykiC-3sc6A:
24.08
1ykiD-3sc6A:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		3 / 3 ARG A 111
GLY A 109
SER A 210
 SO4  A 287 (-3.2A)
None
None
 0.59A 2xctB-3sc6A:
2.3		 2xctB-3sc6A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V7P_A_BEZA430_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 7 ILE A 182
GLY A 183
SER A 184
SER A 214
 None
 0.74A 3v7pA-3sc6A:
2.4		 3v7pA-3sc6A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		5 / 12 ALA A 246
ARG A  73
ALA A  76
ALA A 129
GLY A 128
 None
 0.94A 4oaeA-3sc6A:
1.1		 4oaeA-3sc6A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 7 GLU A  20
GLU A  21
LEU A 153
TYR A 157
 None
None
NAP  A 285 (-4.5A)
None
 1.04A 4twdF-3sc6A:
undetectable
4twdJ-3sc6A:
undetectable		 4twdF-3sc6A:
22.46
4twdJ-3sc6A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		5 / 10 ALA A  84
TYR A  77
PHE A 137
SER A 130
GLY A 134
 None
 1.19A 4xp1A-3sc6A:
undetectable		 4xp1A-3sc6A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 7 ILE A   7
CYH A  60
LEU A 153
ILE A 195
 None
None
NAP  A 285 (-4.5A)
None
 0.97A 4xumA-3sc6A:
undetectable		 4xumA-3sc6A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3sc6 DTDP-4-DEHYDRORHAMNO
SE REDUCTASE
(Bacillus
anthracis) 		4 / 8 VAL A 138
HIS A  59
GLN A  92
GLY A  95
 None
 0.93A 5w3jB-3sc6A:
5.8		 5w3jB-3sc6A:
21.37