SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3scy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 8 ILE A 251
PHE A 334
LEU A 296
VAL A 258
 None
 0.82A 1fslB-3scyA:
undetectable		 1fslB-3scyA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 298
PHE A 310
ALA A 308
LEU A 302
GLN A 282
 None
 1.09A 1rbpA-3scyA:
undetectable		 1rbpA-3scyA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 11 VAL A 230
ILE A 259
LEU A 250
LEU A 193
LEU A 239
 None
 1.16A 2a15A-3scyA:
undetectable		 2a15A-3scyA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.76A 2avvB-3scyA:
undetectable		 2avvB-3scyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_C_CHDC3_0
(LIVER
CARBOXYLESTERASE 1)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 6 LEU A 193
LEU A 268
PRO A 236
VAL A 230
 None
 1.14A 2dqyC-3scyA:
undetectable		 2dqyC-3scyA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.87A 2fxeA-3scyA:
undetectable		 2fxeA-3scyA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.80A 2o4sB-3scyA:
undetectable		 2o4sB-3scyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PRG_A_BRLA1_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 GLY A  42
CYH A 379
HIS A 181
LEU A 128
HIS A 238
 None
None
UNL  A 385 ( 4.0A)
None
None
 1.45A 2prgA-3scyA:
0.0		 2prgA-3scyA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 7 GLY A 306
ILE A 329
GLN A 354
LEU A 326
 None
 0.85A 2xrhA-3scyA:
undetectable		 2xrhA-3scyA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9L_A_AZZA1009_1
(SERUM ALBUMIN)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 8 TYR A 140
GLU A  92
SER A  76
HIS A 238
 UNL  A 385 ( 3.7A)
UNL  A 385 ( 2.8A)
None
None
 1.26A 3b9lA-3scyA:
undetectable		 3b9lA-3scyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ILE A 254
GLY A 255
GLY A 256
ALA A 276
ILE A 251
 None
 1.02A 3jayA-3scyA:
undetectable		 3jayA-3scyA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 5 PHE A 103
ILE A 150
ASN A  74
PHE A  86
 None
 1.10A 3octA-3scyA:
undetectable		 3octA-3scyA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 GLY A  42
CYH A 379
HIS A 181
LEU A 128
HIS A 238
 None
None
UNL  A 385 ( 4.0A)
None
None
 1.39A 4emaA-3scyA:
undetectable		 4emaA-3scyA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_F_D16F301_1
(THYMIDYLATE SYNTHASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 11 GLU A 253
ILE A 254
LEU A 250
ASP A 196
GLY A 198
 UNL  A 385 ( 4.9A)
None
None
None
None
 1.49A 4foxF-3scyA:
undetectable		 4foxF-3scyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.76A 4hlaA-3scyA:
undetectable		 4hlaA-3scyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 11 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.78A 4hlaB-3scyA:
undetectable		 4hlaB-3scyA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 VAL A 307
ALA A 308
TYR A 297
GLY A 323
THR A 327
 None
 1.30A 4mm4A-3scyA:
undetectable		 4mm4A-3scyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 11 VAL A 307
ALA A 308
TYR A 297
GLY A 323
THR A 327
 None
 1.26A 4mmaA-3scyA:
undetectable		 4mmaA-3scyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 5 PHE A 228
HIS A 203
LEU A 180
PRO A 178
 None
 1.26A 4o8zA-3scyA:
undetectable		 4o8zA-3scyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA407_0
(FAD:PROTEIN FMN
TRANSFERASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		3 / 3 ASP A 171
GLY A 233
ASP A 200
 None
MG  A 387 ( 4.3A)
None
 0.50A 4xdtA-3scyA:
undetectable		 4xdtA-3scyA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XLD_A_BRLA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 GLY A  42
CYH A 379
HIS A 181
LEU A 128
HIS A 238
 None
None
UNL  A 385 ( 4.0A)
None
None
 1.37A 4xldA-3scyA:
undetectable		 4xldA-3scyA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 11 LEU A 197
ARG A 237
ILE A 254
ASN A 252
ASP A 171
 None
 1.21A 5hjiA-3scyA:
undetectable		 5hjiA-3scyA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 THR A 273
ALA A 281
LEU A 302
ALA A 275
GLY A 256
 None
 1.22A 5jglA-3scyA:
undetectable		 5jglA-3scyA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		4 / 7 GLN A 175
LEU A 197
ALA A 194
LEU A 193
 None
 0.94A 5nwvA-3scyA:
undetectable		 5nwvA-3scyA:
7.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 GLY A 143
VAL A 230
GLY A 235
PHE A 205
ILE A 145
 None
 1.30A 5tuiB-3scyA:
undetectable		 5tuiB-3scyA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_F_CVIF301_0
(REGULATORY PROTEIN
TETR)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 ALA A 298
GLY A 285
SER A 284
GLU A 253
CYH A 347
 None
None
None
UNL  A 385 ( 4.9A)
None
 1.06A 5vlmF-3scyA:
undetectable		 5vlmF-3scyA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 10 ALA A 194
ASP A 195
ILE A 185
VAL A 147
ILE A 145
 None
 0.87A 6dj2A-3scyA:
undetectable		 6dj2A-3scyA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3scy HYPOTHETICAL
BACTERIAL
6-PHOSPHOGLUCONOLACT
ONASE
(Bacteroides
fragilis) 		5 / 12 GLY A  42
CYH A 379
HIS A 181
LEU A 128
HIS A 238
 None
None
UNL  A 385 ( 4.0A)
None
None
 1.31A 6md4A-3scyA:
undetectable		 6md4A-3scyA:
11.71