SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sd7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_A_REAA502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 12 ALA A 133
ALA A 116
ILE A 104
CYH A 155
LEU A 152
 GOL  A 221 (-3.6A)
None
None
None
None
 1.00A 2aclA-3sd7A:
undetectable
2aclE-3sd7A:
undetectable		 2aclA-3sd7A:
21.19
2aclE-3sd7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 12 VAL A 166
ILE A 148
VAL A 151
LEU A 152
VAL A 157
 None
 1.09A 3w68A-3sd7A:
undetectable		 3w68A-3sd7A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 12 VAL A 166
ILE A 148
VAL A 151
LEU A 152
VAL A 157
 None
 1.14A 3w68C-3sd7A:
undetectable		 3w68C-3sd7A:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 8 VAL A   8
CYH A 155
VAL A 163
ILE A 104
 None
 1.10A 4aftD-3sd7A:
undetectable
4aftE-3sd7A:
undetectable		 4aftD-3sd7A:
21.60
4aftE-3sd7A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 8 LEU A  16
ILE A 211
VAL A 205
GLY A 167
 None
 0.89A 4eq4B-3sd7A:
undetectable		 4eq4B-3sd7A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 12 ASP A  13
VAL A 107
ALA A 108
SER A 110
GLY A 134
 None
None
None
None
GOL  A 221 (-4.2A)
 1.00A 4mm8A-3sd7A:
undetectable		 4mm8A-3sd7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_A_29EA603_1
(TRANSPORTER)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 10 ASP A  13
VAL A 107
ALA A 108
SER A 110
GLY A 134
 None
None
None
None
GOL  A 221 (-4.2A)
 1.03A 4mmdA-3sd7A:
undetectable		 4mmdA-3sd7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMD_B_29EB603_1
(TRANSPORTER)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 12 ASP A  13
VAL A 107
ALA A 108
SER A 110
GLY A 134
 None
None
None
None
GOL  A 221 (-4.2A)
 1.02A 4mmdB-3sd7A:
undetectable		 4mmdB-3sd7A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		3 / 3 LYS A 111
ASN A 143
ASP A  13
 None
 0.84A 4o1eA-3sd7A:
undetectable		 4o1eA-3sd7A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 7 ASN A 101
LYS A 100
TYR A 128
LEU A 106
 None
 0.97A 4yv5B-3sd7A:
undetectable		 4yv5B-3sd7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_A_PCFA1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 6 ILE A 214
ILE A 104
LEU A 105
PHE A  10
 None
 0.84A 5vkqA-3sd7A:
undetectable
5vkqB-3sd7A:
undetectable		 5vkqA-3sd7A:
8.33
5vkqB-3sd7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1806_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 6 ILE A 214
ILE A 104
LEU A 105
PHE A  10
 None
 0.82A 5vkqB-3sd7A:
undetectable
5vkqC-3sd7A:
undetectable		 5vkqB-3sd7A:
8.33
5vkqC-3sd7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 6 ILE A 214
ILE A 104
LEU A 105
PHE A  10
 None
 0.82A 5vkqC-3sd7A:
undetectable
5vkqD-3sd7A:
undetectable		 5vkqC-3sd7A:
8.33
5vkqD-3sd7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1807_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 6 ILE A 214
ILE A 104
LEU A 105
PHE A  10
 None
 0.82A 5vkqA-3sd7A:
undetectable
5vkqD-3sd7A:
undetectable		 5vkqA-3sd7A:
8.33
5vkqD-3sd7A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_H_CVIH301_1
(REGULATORY PROTEIN
TETR)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		4 / 8 GLN A  45
GLY A  48
ILE A  23
ASP A  13
 None
 0.84A 5vlmH-3sd7A:
undetectable		 5vlmH-3sd7A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 3sd7 PUTATIVE PHOSPHATASE
(Clostridioides
difficile) 		5 / 11 ASP A 126
PHE A 129
ILE A 132
ILE A  87
MET A  91
 PGE  A 219 (-3.8A)
None
None
None
None
 1.42A 6fgcA-3sd7A:
2.0		 6fgcA-3sd7A:
16.96