SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sdi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_1
(PROTEIN (ADENOSINE
KINASE))		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 ASP E 142
LEU E 116
GLY E 140
ALA E 112
LEU E  92
 None
 0.98A 1bx4A-3sdiE:
undetectable		 1bx4A-3sdiE:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_B_DP0B190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 ILE E  31
LEU E 160
GLU E 150
GLN E 152
ALA E 172
 None
 1.31A 3apwB-3sdiE:
undetectable		 3apwB-3sdiE:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MS9_B_STIB1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		4 / 7 TYR E  63
VAL E  47
VAL E 229
ILE E  67
 None
 1.19A 3ms9B-3sdiE:
undetectable		 3ms9B-3sdiE:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 TYR E  91
ILE E 138
ALA E 112
ASP E  71
GLN E  95
 None
 1.22A 3nmuB-3sdiE:
undetectable
3nmuJ-3sdiE:
undetectable		 3nmuB-3sdiE:
23.08
3nmuJ-3sdiE:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NYA_A_JTZA1203_1
(BETA-2 ADRENERGIC
RECEPTOR, LYSOZYME)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 THR E 219
VAL E  47
SER E  42
ASN E 185
TYR E 224
 None
 1.39A 3nyaA-3sdiE:
undetectable		 3nyaA-3sdiE:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 HIS E  45
GLU E 188
ILE E 180
LEU E  40
GLY E 193
 None
 1.24A 4foxE-3sdiE:
undetectable		 4foxE-3sdiE:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 10 CYH E  70
LEU E  92
ALA E 112
HIS E  73
LEU E 107
 None
 0.93A 4p65A-3sdiE:
undetectable
4p65B-3sdiE:
undetectable
4p65F-3sdiE:
undetectable
4p65H-3sdiE:
undetectable		 4p65A-3sdiE:
13.95
4p65B-3sdiE:
9.91
4p65F-3sdiE:
9.91
4p65H-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 CYH E  70
LEU E  92
ALA E 112
LEU E 107
HIS E  73
 None
 0.94A 4p65C-3sdiE:
undetectable
4p65D-3sdiE:
undetectable
4p65J-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65C-3sdiE:
13.95
4p65D-3sdiE:
9.91
4p65J-3sdiE:
9.91
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 CYH E  70
LEU E  92
ALA E 112
HIS E  73
LEU E 107
 None
 0.93A 4p65E-3sdiE:
undetectable
4p65F-3sdiE:
undetectable
4p65J-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65E-3sdiE:
13.95
4p65F-3sdiE:
9.91
4p65J-3sdiE:
9.91
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 CYH E  70
LEU E  92
HIS E 147
ALA E 112
LEU E 107
 None
 1.08A 4p65E-3sdiE:
undetectable
4p65F-3sdiE:
undetectable
4p65J-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65E-3sdiE:
13.95
4p65F-3sdiE:
9.91
4p65J-3sdiE:
9.91
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 LEU E 107
HIS E  73
CYH E  70
LEU E  92
ALA E 112
 None
 1.03A 4p65B-3sdiE:
undetectable
4p65D-3sdiE:
undetectable
4p65G-3sdiE:
undetectable
4p65H-3sdiE:
undetectable		 4p65B-3sdiE:
9.91
4p65D-3sdiE:
9.91
4p65G-3sdiE:
13.95
4p65H-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_I_IPHI101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 HIS E  73
LEU E 107
CYH E  70
LEU E  92
ALA E 112
 None
 0.90A 4p65B-3sdiE:
undetectable
4p65D-3sdiE:
undetectable
4p65I-3sdiE:
undetectable
4p65J-3sdiE:
undetectable		 4p65B-3sdiE:
9.91
4p65D-3sdiE:
9.91
4p65I-3sdiE:
13.95
4p65J-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_K_IPHK101_0
(INSULIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 LEU E 107
HIS E  73
CYH E  70
LEU E  92
ALA E 112
 None
 0.90A 4p65F-3sdiE:
undetectable
4p65H-3sdiE:
undetectable
4p65K-3sdiE:
undetectable
4p65L-3sdiE:
undetectable		 4p65F-3sdiE:
9.91
4p65H-3sdiE:
9.91
4p65K-3sdiE:
13.95
4p65L-3sdiE:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PXM_B_ESTB2000_1
(ESTROGEN RECEPTOR)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 11 LEU E  51
ALA E  50
ILE E  31
GLY E 135
LEU E 137
 None
 1.09A 4pxmB-3sdiE:
undetectable		 4pxmB-3sdiE:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A6I_A_TCWA1124_1
(TRANSTHYRETIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		4 / 6 LEU E 176
ALA E 164
LEU E  40
VAL E  36
 None
 1.17A 5a6iA-3sdiE:
undetectable		 5a6iA-3sdiE:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		5 / 12 LEU E  51
ALA E  50
ILE E  31
GLY E 135
LEU E 137
 None
 1.10A 5gs4A-3sdiE:
undetectable		 5gs4A-3sdiE:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 3sdi PROTEASOME COMPONENT
PRE5
(Saccharomyces
cerevisiae) 		3 / 3 GLU E 204
LEU E 201
ARG E 168
 None
 0.69A 6d8fA-3sdiE:
undetectable		 6d8fA-3sdiE:
16.67