SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sds'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		4 / 8 ASP A 254
VAL A 252
GLY A 293
GLY A 292
 None
 0.87A 1ekjE-3sdsA:
undetectable
1ekjF-3sdsA:
undetectable		 1ekjE-3sdsA:
21.86
1ekjF-3sdsA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		5 / 11 PHE A 159
ILE A 229
ALA A 201
LEU A 200
ALA A 155
 None
 1.49A 1jb0B-3sdsA:
undetectable		 1jb0B-3sdsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		4 / 5 ALA A 212
ALA A 294
ALA A 289
VAL A 284
 None
 0.84A 2nyrB-3sdsA:
3.1		 2nyrB-3sdsA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		4 / 6 ARG A 275
ASP A 192
GLN A 244
GLU A 220
 None
 1.08A 2ya7C-3sdsA:
undetectable		 2ya7C-3sdsA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		5 / 11 PHE A 159
ILE A 229
ALA A 201
LEU A 200
ALA A 155
 None
 1.49A 3pcqB-3sdsA:
undetectable		 3pcqB-3sdsA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3sds ORNITHINE
CARBAMOYLTRANSFERASE
, MITOCHONDRIAL
(Coccidioides
immitis) 		5 / 11 LEU A  36
ILE A 335
LEU A 338
PHE A 341
VAL A 122
 None
 1.09A 3w67A-3sdsA:
undetectable		 3w67A-3sdsA:
22.48