SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sf6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 315
PHE A 263
LEU A  26
PHE A 259
 None
 1.07A 1wrlE-3sf6A:
undetectable
1wrlF-3sf6A:
undetectable		 1wrlE-3sf6A:
10.53
1wrlF-3sf6A:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZQ9_A_SAMA4000_0
(PROBABLE
DIMETHYLADENOSINE
TRANSFERASE)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 HIS A  48
ILE A  45
LEU A  67
VAL A 183
PRO A  59
 None
 1.03A 1zq9A-3sf6A:
undetectable		 1zq9A-3sf6A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7I_A_TESA205_1
(ANDROGEN RECEPTOR)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  67
LEU A  70
VAL A  41
ARG A  43
MET A  75
 None
 1.25A 2q7iA-3sf6A:
undetectable		 2q7iA-3sf6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7K_A_TESA304_1
(ANDROGEN RECEPTOR)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  67
LEU A  70
VAL A  41
ARG A  43
MET A  75
 None
 1.24A 2q7kA-3sf6A:
undetectable		 2q7kA-3sf6A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 LEU A 251
PRO A 250
LEU A 254
 None
 0.51A 3hcrA-3sf6A:
undetectable		 3hcrA-3sf6A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 7 LEU A 171
ARG A 161
THR A 163
ALA A 162
 None
 1.30A 3mbgA-3sf6A:
undetectable
3mbgB-3sf6A:
undetectable		 3mbgA-3sf6A:
14.81
3mbgB-3sf6A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 9 ARG A  34
LEU A  92
ALA A 314
GLY A 308
ILE A  20
 EDO  A 413 (-4.0A)
EDO  A 413 ( 4.6A)
None
None
None
 1.34A 3spkA-3sf6A:
undetectable		 3spkA-3sf6A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_TESA1000_1
(ANDROGEN RECEPTOR)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  67
LEU A  70
VAL A  41
ARG A  43
MET A  75
 None
 1.28A 3zqtA-3sf6A:
undetectable		 3zqtA-3sf6A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A  95
ALA A 265
HIS A 367
TYR A 307
ARG A 270
 EDO  A 413 ( 4.5A)
None
None
None
EDO  A 413 (-3.9A)
 1.36A 4ejwA-3sf6A:
1.5		 4ejwA-3sf6A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  88
ALA A 314
PHE A 259
 None
 0.75A 4olbA-3sf6A:
undetectable		 4olbA-3sf6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 ASP A  17
LEU A 313
PHE A 263
GLY A 267
ALA A  99
 EDO  A 413 (-2.9A)
None
None
None
None
 1.29A 4retA-3sf6A:
2.4		 4retA-3sf6A:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 GLU A  96
TYR A 307
GLU A 274
 EDO  A 413 (-4.7A)
None
None
 0.73A 4ryaA-3sf6A:
undetectable		 4ryaA-3sf6A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  88
ALA A 314
PHE A 259
 None
 0.69A 4w5nA-3sf6A:
undetectable		 4w5nA-3sf6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  88
ALA A 314
PHE A 259
 None
 0.75A 4z4iA-3sf6A:
undetectable		 4z4iA-3sf6A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_0
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 12 LEU A 315
GLY A 264
ASN A 338
GLU A  96
LEU A  92
 None
None
None
EDO  A 413 (-4.7A)
EDO  A 413 ( 4.6A)
 1.41A 5emlA-3sf6A:
undetectable		 5emlA-3sf6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 VAL A  88
ALA A 314
PHE A 259
 None
 0.74A 5js1A-3sf6A:
undetectable		 5js1A-3sf6A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		4 / 8 ARG A  38
GLU A  96
GLY A 100
ASP A 271
 EDO  A 413 ( 4.9A)
EDO  A 413 (-4.7A)
None
None
 1.16A 5kf8A-3sf6A:
undetectable		 5kf8A-3sf6A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		5 / 10 VAL A 186
ASP A 185
ALA A 115
GLY A 138
LEU A  73
 None
 1.15A 5m5cE-3sf6A:
undetectable		 5m5cE-3sf6A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3sf6 GLUTARYL-COA
DEHYDROGENASE
(Mycolicibacteriu
m
smegmatis) 		3 / 3 THR A 147
MET A 158
HIS A 151
 FDA  A 400 (-3.3A)
None
None
 1.02A 5uunA-3sf6A:
1.1		 5uunA-3sf6A:
23.57