SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sfw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4L_C_DCFC1353_1
(ADENOSINE DEAMINASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 HIS A  58
HIS A  60
MET A 125
HIS A 239
ASP A 315
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
None
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 1.27A 1a4lC-3sfwA:
15.7		 1a4lC-3sfwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 4 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.95A 1e7bA-3sfwA:
undetectable		 1e7bA-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 4 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.88A 1e7bB-3sfwA:
undetectable		 1e7bB-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E9Y_B_HAEB800_1
(UREASE SUBUNIT BETA)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.47A 1e9yB-3sfwA:
23.5		 1e9yB-3sfwA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FWE_C_HAEC989_1
(UREASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.61A 1fweC-3sfwA:
24.4		 1fweC-3sfwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 10 PRO A  57
LEU A 375
PHE A 376
THR A 311
GLY A 261
 None
 0.97A 1h4oA-3sfwA:
undetectable
1h4oB-3sfwA:
undetectable		 1h4oA-3sfwA:
18.10
1h4oB-3sfwA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLU A 262
HIS A 239
HIS A 208
HIS A 183
TYR A 155
 None
ZN  A 501 (-3.4A)
None
ZN  A 501 (-3.3A)
None
 1.41A 1o86A-3sfwA:
undetectable		 1o86A-3sfwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_1
(ANGIOTENSIN
CONVERTING ENZYME)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLU A 262
HIS A 239
PHE A  65
HIS A 183
TYR A 155
 None
ZN  A 501 (-3.4A)
None
ZN  A 501 (-3.3A)
None
 1.36A 1o86A-3sfwA:
undetectable		 1o86A-3sfwA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T69_A_SHHA379_1
(HISTONE DEACETYLASE
8)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 TYR A 285
GLY A 338
HIS A 316
ASP A  72
MET A 411
 None
 1.50A 1t69A-3sfwA:
undetectable		 1t69A-3sfwA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T6Z_A_RBFA296_1
(RIBOFLAVIN
KINASE/FMN
ADENYLYLTRANSFERASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 11 THR A 311
VAL A  90
GLU A 262
ARG A 455
LEU A 179
 None
 1.13A 1t6zA-3sfwA:
undetectable		 1t6zA-3sfwA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPO_H_TESH1010_1
(ANTI-TESTOSTERONE
(HEAVY CHAIN)
ANTI-TESTOSTERONE
(LIGHT CHAIN))		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 ALA A 391
GLY A 434
LEU A 431
PHE A 436
VAL A  42
 None
 1.13A 1vpoH-3sfwA:
undetectable
1vpoL-3sfwA:
undetectable		 1vpoH-3sfwA:
18.71
1vpoL-3sfwA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 8 ARG A 451
ALA A 449
ALA A 435
GLU A  26
 None
 0.79A 2bxgA-3sfwA:
undetectable		 2bxgA-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 7 ASP A 426
THR A 347
ILE A 404
ASN A 416
 None
 1.27A 2jc9A-3sfwA:
undetectable		 2jc9A-3sfwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLN A 381
ASP A 119
GLY A  53
LEU A  51
SER A 432
 None
 1.30A 2nv4A-3sfwA:
undetectable		 2nv4A-3sfwA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 7 ILE A 367
GLY A 307
VAL A 240
LEU A 375
 None
 0.93A 3elzA-3sfwA:
undetectable		 3elzA-3sfwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 10 ILE A 308
ILE A 249
VAL A 237
PRO A 289
LEU A 304
 None
 1.18A 3elzC-3sfwA:
undetectable		 3elzC-3sfwA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLY A 307
SER A 302
LEU A 268
VAL A 312
ILE A 367
 None
 1.14A 3g9eA-3sfwA:
undetectable		 3g9eA-3sfwA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB0_A_DIFA701_1
(LACTOTRANSFERRIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 4 PRO A 398
TYR A  49
GLY A  47
THR A  46
 ACT  A 463 ( 4.7A)
ACT  A 463 ( 3.7A)
ACT  A 463 (-3.8A)
None
 1.34A 3ib0A-3sfwA:
undetectable		 3ib0A-3sfwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LCV_B_SAMB301_0
(SISOMICIN-GENTAMICIN
RESISTANCE METHYLASE
SGM)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 PHE A 376
SER A 148
THR A 147
ILE A  89
LEU A 124
 None
 1.19A 3lcvB-3sfwA:
undetectable		 3lcvB-3sfwA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 7 GLY A 425
PRO A 398
TYR A  49
GLY A  47
THR A  46
 None
ACT  A 463 ( 4.7A)
ACT  A 463 ( 3.7A)
ACT  A 463 (-3.8A)
None
 1.40A 3tajA-3sfwA:
undetectable		 3tajA-3sfwA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 6 SER A 369
LEU A  51
THR A 368
ARG A 345
 None
 1.45A 3thrB-3sfwA:
undetectable		 3thrB-3sfwA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_1
(MNMC2)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 6 GLU A 419
ASP A 344
ASP A 414
GLU A 343
 None
 1.28A 3vywA-3sfwA:
undetectable		 3vywA-3sfwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 6 GLY A 425
VAL A 400
PRO A 398
GLY A  47
 None
None
ACT  A 463 ( 4.7A)
ACT  A 463 (-3.8A)
 0.80A 4dxuA-3sfwA:
undetectable		 4dxuA-3sfwA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FIM_A_CELA711_1
(LACTOTRANSFERRIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 9 GLY A 425
VAL A 400
PRO A 398
TYR A  49
GLY A  47
 None
None
ACT  A 463 ( 4.7A)
ACT  A 463 ( 3.7A)
ACT  A 463 (-3.8A)
 1.16A 4fimA-3sfwA:
undetectable		 4fimA-3sfwA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 7 GLY A 425
VAL A 400
PRO A 398
GLY A  47
 None
None
ACT  A 463 ( 4.7A)
ACT  A 463 (-3.8A)
 0.83A 4forA-3sfwA:
undetectable		 4forA-3sfwA:
23.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H9M_A_HAEA929_1
(UREASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 5 HIS A  58
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.45A 4h9mA-3sfwA:
25.4		 4h9mA-3sfwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K17_B_OHBB701_0
(LEUCINE-RICH
REPEAT-CONTAINING
PROTEIN 16A)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 5 GLU A 185
ARG A 212
PRO A 289
SER A 241
 None
 1.39A 4k17B-3sfwA:
2.2		 4k17B-3sfwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBP_C_HAEC800_1
(PROTEIN (UREASE
(CHAIN C)))		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 6 HIS A  58
HIS A  60
HIS A 183
HIS A 239
ASP A 315
 ZN  A 502 (-3.3A)
ZN  A 502 (-3.3A)
ZN  A 501 (-3.3A)
ZN  A 501 (-3.4A)
ZN  A 502 (-2.7A)
 0.48A 4ubpC-3sfwA:
24.5		 4ubpC-3sfwA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 4 GLY A  84
LEU A  61
PHE A  74
ILE A  89
 None
 0.86A 4xv2A-3sfwA:
undetectable		 4xv2A-3sfwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 4 GLY A  85
LEU A  61
PHE A  74
ILE A  89
 None
 0.95A 4xv2A-3sfwA:
undetectable		 4xv2A-3sfwA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDY_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.23A 4zdyA-3sfwA:
undetectable		 4zdyA-3sfwA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZVM_A_DM2A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLY A  84
GLY A  85
THR A  86
GLU A 343
ILE A 342
 None
 1.23A 4zvmA-3sfwA:
undetectable
4zvmB-3sfwA:
undetectable		 4zvmA-3sfwA:
19.23
4zvmB-3sfwA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1343_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 5 ALA A 216
ARG A 292
HIS A 183
ALA A 184
 None
None
ZN  A 501 (-3.3A)
None
 1.24A 5a06C-3sfwA:
undetectable
5a06D-3sfwA:
undetectable		 5a06C-3sfwA:
22.84
5a06D-3sfwA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 7 ALA A 233
ASP A 163
ARG A 223
GLU A 219
 None
 0.92A 5btdA-3sfwA:
undetectable
5btdB-3sfwA:
undetectable
5btdC-3sfwA:
undetectable		 5btdA-3sfwA:
21.78
5btdB-3sfwA:
21.47
5btdC-3sfwA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 7 ALA A 233
ASP A 163
ARG A 223
GLU A 219
 None
 0.90A 5btdA-3sfwA:
undetectable
5btdC-3sfwA:
undetectable
5btdD-3sfwA:
undetectable		 5btdA-3sfwA:
21.78
5btdC-3sfwA:
21.78
5btdD-3sfwA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEN_B_5OGB804_1
(HDAC6 PROTEIN)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 HIS A 239
HIS A  58
PHE A  92
LEU A 159
TYR A 155
 ZN  A 501 (-3.4A)
ZN  A 502 (-3.3A)
KCX  A 150 ( 3.7A)
None
None
 1.48A 5eenB-3sfwA:
undetectable		 5eenB-3sfwA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 GLY A 261
ILE A 118
GLY A  85
PHE A 376
THR A 263
 None
 1.26A 5eslA-3sfwA:
undetectable		 5eslA-3sfwA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.21A 5n0rA-3sfwA:
undetectable		 5n0rA-3sfwA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.21A 5n0wA-3sfwA:
undetectable		 5n0wA-3sfwA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 ILE A 118
GLY A 450
PHE A 443
ALA A  81
VAL A 430
 None
 1.20A 5n0xB-3sfwA:
undetectable		 5n0xB-3sfwA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		4 / 6 LEU A 101
VAL A 126
LEU A 149
ARG A 172
 None
KCX  A 150 ( 4.3A)
KCX  A 150 ( 4.3A)
None
 0.97A 5x7zA-3sfwA:
undetectable		 5x7zA-3sfwA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_2
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 10 HIS A 109
ALA A 112
SER A 148
VAL A 453
ARG A 455
 None
 0.99A 6b89B-3sfwA:
0.7		 6b89B-3sfwA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 3sfw DIHYDROPYRIMIDINASE
(Brevibacillus
agri) 		5 / 12 LEU A 361
VAL A 365
SER A 369
THR A 370
VAL A 394
 None
 1.42A 6drxA-3sfwA:
undetectable		 6drxA-3sfwA:
21.85