SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sfy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		3 / 4 VAL A 287
TRP A 326
TRP A 231
 None
 1.38A 1gmkA-3sfyA:
undetectable
1gmkB-3sfyA:
undetectable		 1gmkA-3sfyA:
6.56
1gmkB-3sfyA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 7 THR A  85
SER A  86
ARG A 121
LEU A 116
 None
 1.03A 1ibgL-3sfyA:
undetectable		 1ibgL-3sfyA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 6 TYR A  35
TYR A  39
HIS A  73
PRO A  29
 None
 1.35A 1q13A-3sfyA:
undetectable		 1q13A-3sfyA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 4 LEU A 253
PRO A 250
LEU A 249
ARG A 303
 None
 1.40A 2qd2A-3sfyA:
undetectable		 2qd2A-3sfyA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 ARG A 322
ASP A 319
TRP A 326
 None
 1.22A 4xdqA-3sfyA:
undetectable		 4xdqA-3sfyA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVX_A_GMRA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C3)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 TYR A 150
LEU A 151
TRP A 192
LEU A 196
SER A 159
 None
 1.42A 4yvxA-3sfyA:
undetectable		 4yvxA-3sfyA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 8 PRO A 127
PHE A 158
SER A 156
TYR A 195
 None
 1.27A 5amiB-3sfyA:
undetectable		 5amiB-3sfyA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 TRP A 112
ARG A 115
LEU A 151
 None
 0.81A 5dbyA-3sfyA:
undetectable		 5dbyA-3sfyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 TRP A 190
ARG A 193
LEU A 234
 None
 0.87A 5dbyA-3sfyA:
undetectable		 5dbyA-3sfyA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		3 / 3 TRP A 148
ILE A 134
SER A 137
 None
 0.94A 5gqbA-3sfyA:
undetectable		 5gqbA-3sfyA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		5 / 12 LEU A 279
ILE A 217
THR A 256
ALA A 290
LEU A 234
 None
 1.29A 5ienA-3sfyA:
undetectable		 5ienA-3sfyA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_A_ADNA502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 4 GLU A  64
THR A  63
THR A  85
LEU A 118
 None
 1.49A 5v96A-3sfyA:
undetectable		 5v96A-3sfyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V96_B_ADNB502_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 4 GLU A  64
THR A  63
THR A  85
LEU A 118
 None
 1.50A 5v96B-3sfyA:
undetectable		 5v96B-3sfyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCV_A_1N1A404_2
(MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE)		 3sfy CRYPTOCOCCUS
NEOFORMANS PROTEIN
FARNESYLTRANSFERASE
ALPHA SUBUNIT
(Cryptococcus
neoformans) 		4 / 5 VAL A 198
HIS A 152
LEU A 173
CYH A 176
 None
 1.44A 5vcvA-3sfyA:
undetectable		 5vcvA-3sfyA:
25.74