SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3sfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_C_DVAC6_0
(GRAMICIDIN A)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ALA A 329
VAL A 299
TRP A 338
 None
 0.83A 1av2C-3sfzA:
undetectable
1av2D-3sfzA:
undetectable		 1av2C-3sfzA:
1.80
1av2D-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 6 ILE A 826
TRP A 806
ASP A 754
PRO A 753
 None
 1.13A 1ditH-3sfzA:
undetectable
1ditP-3sfzA:
undetectable		 1ditH-3sfzA:
12.04
1ditP-3sfzA:
1.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 TRP A1202
VAL A1184
TRP A1203
 None
 1.18A 1gmkC-3sfzA:
undetectable
1gmkD-3sfzA:
undetectable		 1gmkC-3sfzA:
1.80
1gmkD-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.92A 1hrkA-3sfzA:
2.1		 1hrkA-3sfzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.92A 1hrkB-3sfzA:
2.2		 1hrkB-3sfzA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 TRP A 806
HIS A 827
LYS A 812
 None
 1.40A 1l7xA-3sfzA:
undetectable		 1l7xA-3sfzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 392
ASP A 243
LYS A 198
 None
 1.01A 1lqtB-3sfzA:
undetectable		 1lqtB-3sfzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 392
ASP A 243
LYS A 198
 None
 1.03A 1lquB-3sfzA:
undetectable		 1lquB-3sfzA:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M4D_A_TOYA500_1
(AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 10 ASP A1024
SER A1062
SER A1060
ASP A1064
THR A1066
 None
 1.47A 1m4dA-3sfzA:
undetectable		 1m4dA-3sfzA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 4 GLY A1179
LYS A1177
GLY A1198
HIS A1177
 None
 1.27A 1mf1A-3sfzA:
undetectable		 1mf1A-3sfzA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_F_AG2F7016_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 LEU A 568
GLY A 567
ILE A 563
GLU A 587
 None
 0.91A 1n13A-3sfzA:
undetectable
1n13F-3sfzA:
undetectable		 1n13A-3sfzA:
3.42
1n13F-3sfzA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 SER A1227
PHE A 930
SER A1187
VAL A1194
THR A1192
 None
 1.33A 1q23B-3sfzA:
undetectable		 1q23B-3sfzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 SER A1227
PHE A 930
SER A1187
VAL A1194
THR A1192
 None
 1.36A 1q23F-3sfzA:
undetectable		 1q23F-3sfzA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 LEU A 568
LYS A 585
LEU A 582
ALA A 584
 None
 1.07A 1sn0B-3sfzA:
undetectable
1sn0D-3sfzA:
undetectable		 1sn0B-3sfzA:
7.57
1sn0D-3sfzA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_C_T44C601_1
(TRANSTHYRETIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 9 LYS A 585
LEU A 582
ALA A 584
LEU A 568
GLU A 572
 None
 1.44A 1sn0A-3sfzA:
undetectable
1sn0C-3sfzA:
1.9		 1sn0A-3sfzA:
7.57
1sn0C-3sfzA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_A_URFA999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 ALA A 816
TYR A 845
ILE A 843
ASP A 847
 None
 1.04A 1upfA-3sfzA:
undetectable		 1upfA-3sfzA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_C_DVAC6_0
(GRAMICIDIN D)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ALA A 329
VAL A 299
TRP A 338
 None
 0.80A 1w5uC-3sfzA:
undetectable
1w5uD-3sfzA:
undetectable		 1w5uC-3sfzA:
1.80
1w5uD-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_B_SAMB302_0
(RRNA
METHYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 10 THR A1182
GLY A1179
GLY A1149
ILE A1224
LEU A1200
 None
 0.95A 1x7pA-3sfzA:
undetectable
1x7pB-3sfzA:
undetectable		 1x7pA-3sfzA:
13.04
1x7pB-3sfzA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2002_1
(SERUM ALBUMIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 10 ALA A 164
ALA A 167
LEU A 173
LEU A 140
VAL A 150
 None
 1.17A 2bxeA-3sfzA:
undetectable		 2bxeA-3sfzA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 TRP A 338
ALA A 329
VAL A 299
 None
 0.71A 2izqA-3sfzA:
undetectable
2izqB-3sfzA:
undetectable		 2izqA-3sfzA:
1.80
2izqB-3sfzA:
1.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZ7_A_CA4A1_2
(ANDROGEN RECEPTOR)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 6 LEU A 195
TRP A 149
MET A 231
LEU A 240
 None
 1.34A 2oz7A-3sfzA:
undetectable		 2oz7A-3sfzA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGR_A_T27A556_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.04A 3bgrA-3sfzA:
1.3
3bgrB-3sfzA:
undetectable		 3bgrA-3sfzA:
17.91
3bgrB-3sfzA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 VAL A 162
LEU A 163
GLY A 159
SER A 320
PRO A 321
 ADP  A1250 (-4.2A)
None
ADP  A1250 (-3.0A)
None
ADP  A1250 (-4.5A)
 1.32A 3bjwE-3sfzA:
undetectable		 3bjwE-3sfzA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 VAL A 229
LEU A 230
ASP A 255
LEU A 199
LEU A 195
 None
 1.05A 3cjtK-3sfzA:
undetectable		 3cjtK-3sfzA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CKK_A_SAMA301_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 GLY A 894
ALA A 808
LEU A 854
ASP A 847
THR A 911
 None
 1.06A 3ckkA-3sfzA:
undetectable		 3ckkA-3sfzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 THR A1182
GLY A1179
GLY A1149
ILE A1224
LEU A1200
 None
 0.91A 3dcmX-3sfzA:
undetectable		 3dcmX-3sfzA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 ARG A 557
ASP A 902
GLU A 659
GLU A 221
 None
 1.35A 3dh0A-3sfzA:
undetectable		 3dh0A-3sfzA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 ILE A 327
PHE A 444
PHE A 350
LYS A 348
 None
 0.96A 3em0B-3sfzA:
2.6		 3em0B-3sfzA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWW_A_SFXA801_1
(TRANSPORTER)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 GLY A 159
LEU A 163
ILE A 152
ALA A 165
ASP A 243
 ADP  A1250 (-3.0A)
None
None
None
None
 1.04A 3gwwA-3sfzA:
undetectable		 3gwwA-3sfzA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 ALA A 223
LEU A 230
LEU A 199
ILE A 260
CYH A 258
 None
 0.84A 3h0aA-3sfzA:
undetectable		 3h0aA-3sfzA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A1189
PHE A1230
SER A1136
 None
 0.93A 3i5uB-3sfzA:
5.8		 3i5uB-3sfzA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX2_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 VAL A 127
VAL A 324
PHE A 298
GLU A 293
 ADP  A1250 (-3.7A)
None
None
None
 1.23A 3jx2A-3sfzA:
undetectable
3jx2B-3sfzA:
undetectable		 3jx2A-3sfzA:
14.42
3jx2B-3sfzA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ALA A 329
VAL A 299
TRP A 338
 None
 0.70A 3l8lA-3sfzA:
undetectable
3l8lB-3sfzA:
undetectable		 3l8lA-3sfzA:
1.80
3l8lB-3sfzA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_C_DVAC6_0
(GRAMICIDIN D)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ALA A 329
VAL A 299
TRP A 338
 None
 0.78A 3l8lC-3sfzA:
undetectable
3l8lD-3sfzA:
undetectable		 3l8lC-3sfzA:
1.80
3l8lD-3sfzA:
2.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 PHE A 298
GLU A 293
VAL A 127
VAL A 324
 None
None
ADP  A1250 (-3.7A)
None
 1.25A 3nlqA-3sfzA:
undetectable
3nlqB-3sfzA:
undetectable		 3nlqA-3sfzA:
14.42
3nlqB-3sfzA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 473
LEU A 500
LEU A 503
ALA A 494
ALA A 492
 None
 1.13A 3vw7A-3sfzA:
undetectable		 3vw7A-3sfzA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 LEU A 174
VAL A 119
GLY A 118
TRP A 184
 None
 0.88A 3w1wA-3sfzA:
2.2		 3w1wA-3sfzA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQT_A_30ZA1920_1
(ANDROGEN RECEPTOR)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 6 PRO A 147
GLY A 148
LEU A 143
ASN A 144
 None
 1.02A 3zqtA-3sfzA:
undetectable		 3zqtA-3sfzA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 405
ARG A 466
ASP A 385
 None
 0.85A 4fp9A-3sfzA:
undetectable		 4fp9A-3sfzA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 626
ARG A 629
ASP A 668
 None
 0.77A 4fp9D-3sfzA:
undetectable		 4fp9D-3sfzA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 626
ARG A 629
ASP A 668
 None
 0.77A 4fzvA-3sfzA:
undetectable		 4fzvA-3sfzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAR_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 TRP A1070
ILE A1019
THR A1012
VAL A1026
 None
 1.39A 4iarA-3sfzA:
undetectable		 4iarA-3sfzA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 LYS A 820
LEU A 822
ALA A 817
 None
 0.55A 4iizA-3sfzA:
undetectable		 4iizA-3sfzA:
6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_2
(TRANSPORTER)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 SER A 371
MET A 368
ASP A 381
 None
 0.82A 4mm4B-3sfzA:
undetectable		 4mm4B-3sfzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM9_A_FVXA603_1
(TRANSPORTER)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 ASP A 903
VAL A 864
ALA A 858
SER A 901
GLY A 887
 None
 1.13A 4mm9A-3sfzA:
undetectable		 4mm9A-3sfzA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 LEU A 650
ASP A 626
GLU A 645
VAL A 908
 None
 1.30A 4nkvA-3sfzA:
undetectable		 4nkvA-3sfzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 ILE A 370
ARG A 343
GLU A 366
VAL A 323
 None
 1.02A 4nkxC-3sfzA:
undetectable		 4nkxC-3sfzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 ILE A 370
ARG A 343
GLU A 366
VAL A 323
 None
 0.98A 4nkxD-3sfzA:
undetectable		 4nkxD-3sfzA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 ALA A 919
ILE A 956
GLY A 951
VAL A1236
ILE A 926
 None
 0.94A 4q5mA-3sfzA:
undetectable		 4q5mA-3sfzA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_1
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 GLN A 259
LEU A 239
SER A 238
ASP A 225
 None
 1.20A 4qtuD-3sfzA:
undetectable		 4qtuD-3sfzA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UY8_7_TRP71002_0
(TRYPTOPHANASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 4 ILE A 943
ASN A 917
ILE A 920
VAL A 921
 None
 1.16A 4uy87-3sfzA:
undetectable		 4uy87-3sfzA:
1.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
GBL  A1251 (-4.2A)
None
None
None
 1.06A 4xiwB-3sfzA:
undetectable
4xiwE-3sfzA:
undetectable		 4xiwB-3sfzA:
10.83
4xiwE-3sfzA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_B_AZMB402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 HIS A 490
HIS A 457
LEU A 389
VAL A 395
PRO A 396
 None
GBL  A1251 (-4.2A)
None
None
None
 1.19A 4xiwB-3sfzA:
undetectable
4xiwE-3sfzA:
undetectable		 4xiwB-3sfzA:
10.83
4xiwE-3sfzA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 GLU A 572
THR A 573
HIS A 881
LEU A 550
 None
None
None
GBL  A1254 ( 4.2A)
 1.27A 5axaC-3sfzA:
undetectable		 5axaC-3sfzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYM_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.13A 5cymA-3sfzA:
undetectable		 5cymA-3sfzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CYQ_A_T27A601_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.13A 5cyqA-3sfzA:
undetectable		 5cyqA-3sfzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_1
(CDL2.3A)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 758
LEU A 730
LEU A 714
PHE A 751
ALA A 664
 None
 1.11A 5ieoA-3sfzA:
2.6		 5ieoA-3sfzA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_1
(CDL2.3B)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 758
LEU A 730
LEU A 714
PHE A 751
ALA A 664
 None
 1.15A 5iepA-3sfzA:
undetectable		 5iepA-3sfzA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 VAL A 124
LEU A 306
MET A 301
 None
 0.73A 5ikrA-3sfzA:
undetectable		 5ikrA-3sfzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 6 GLY A1198
THR A1219
TYR A1199
GLY A1218
 None
 0.79A 5k4pA-3sfzA:
undetectable		 5k4pA-3sfzA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L7I_A_VISA1202_1
(SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 ASN A1238
ASP A1237
TYR A1243
ASN A 551
LEU A 550
 None
None
None
GBL  A1254 (-3.4A)
GBL  A1254 ( 4.2A)
 1.48A 5l7iA-3sfzA:
2.9		 5l7iA-3sfzA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 CYH A 317
LEU A 345
ALA A 367
ILE A 314
ILE A 294
 None
None
None
None
ADP  A1250 ( 4.8A)
 1.10A 5mioB-3sfzA:
undetectable		 5mioB-3sfzA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 ILE A 414
PHE A 418
ASP A 385
SER A 387
 None
 1.40A 5nr3A-3sfzA:
undetectable		 5nr3A-3sfzA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NR3_A_95EA401_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 3B)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 ILE A 414
TRP A 404
ASP A 385
SER A 387
 None
 1.40A 5nr3A-3sfzA:
undetectable		 5nr3A-3sfzA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 8 GLN A 545
GLU A 525
ILE A 510
GLN A 583
 None
 0.98A 5vlmD-3sfzA:
undetectable		 5vlmD-3sfzA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WYQ_A_SAMA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 4 ASP A 754
SER A 752
ASP A 755
HIS A 713
 None
 1.39A 5wyqB-3sfzA:
undetectable		 5wyqB-3sfzA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 6 LEU A 400
TYR A 467
ARG A 466
THR A 462
 None
 1.06A 5x1fA-3sfzA:
undetectable
5x1fJ-3sfzA:
undetectable		 5x1fA-3sfzA:
16.89
5x1fJ-3sfzA:
5.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 SER A1195
HIS A1177
TYR A1199
 None
 0.95A 5y2tA-3sfzA:
undetectable		 5y2tA-3sfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y80_A_IREA402_0
(CYCLIN-G-ASSOCIATED
KINASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 11 ALA A 759
ASP A 847
SER A 805
ILE A 869
ILE A 835
 None
 1.25A 5y80A-3sfzA:
undetectable		 5y80A-3sfzA:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 626
ARG A 629
ASP A 668
 None
 0.80A 5zvgA-3sfzA:
undetectable		 5zvgA-3sfzA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		3 / 3 ASP A 626
ARG A 629
ASP A 668
 None
 0.79A 5zvgB-3sfzA:
undetectable		 5zvgB-3sfzA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 VAL A 442
THR A 446
VAL A 399
LEU A 415
 None
GBL  A1251 (-3.6A)
None
None
 0.82A 6bqgA-3sfzA:
undetectable		 6bqgA-3sfzA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ELI_A_T27A701_1
(REVERSE
TRANSCRIPTASE)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		5 / 12 LEU A 386
TYR A 436
PHE A 425
LEU A 424
TYR A 383
 None
None
ADP  A1250 (-3.4A)
None
None
 1.18A 6eliA-3sfzA:
undetectable		 6eliA-3sfzA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 5 ILE A1244
THR A 935
THR A 602
LEU A 922
 None
 0.99A 6f3mD-3sfzA:
undetectable		 6f3mD-3sfzA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1
(Mus
musculus) 		4 / 7 HIS A 457
ASP A 443
THR A 446
HIS A 490
 GBL  A1251 (-4.2A)
None
GBL  A1251 (-3.6A)
None
 1.48A 6nmfN-3sfzA:
undetectable
6nmfP-3sfzA:
undetectable		 6nmfN-3sfzA:
16.89
6nmfP-3sfzA:
11.12